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    Lzts1 leucine zipper, putative tumor suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 211134, updated on 2-May-2024

    Summary

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    Official Symbol
    Lzts1provided by MGI
    Official Full Name
    leucine zipper, putative tumor suppressor 1provided by MGI
    Primary source
    MGI:MGI:2684762
    See related
    Ensembl:ENSMUSG00000036306 AllianceGenome:MGI:2684762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F37; FEZ1; PSD-Zip70
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in negative regulation of macroautophagy; regulation of dendrite morphogenesis; and regulation of synaptic plasticity. Predicted to be located in several cellular components, including apical plasma membrane; dendritic shaft; and postsynaptic density. Predicted to be active in dendritic spine. Is expressed in several structures, including brain and metanephros. Human ortholog(s) of this gene implicated in esophageal cancer and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 14.3), cortex adult (RPKM 13.3) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (69585311..69636901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69132659..69184249, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33103 Neighboring gene predicted gene, 33052 Neighboring gene STARR-seq mESC enhancer starr_21713 Neighboring gene STARR-seq mESC enhancer starr_21714 Neighboring gene solute carrier family 18 (vesicular monoamine), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E8237 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit B2 Neighboring gene STARR-positive B cell enhancer ABC_E8238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71645510-71645697 Neighboring gene predicted gene, 39187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71700363-71700564 Neighboring gene STARR-positive B cell enhancer ABC_E6640 Neighboring gene STARR-positive B cell enhancer ABC_E3775 Neighboring gene STARR-seq mESC enhancer starr_21725 Neighboring gene predicted gene, 39188 Neighboring gene zinc finger protein 930 Neighboring gene predicted gene, 33178

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Social Stress-Induced Postsynaptic Hyporesponsiveness in Glutamatergic Synapses Is Mediated by PSD-Zip70-Rap2 Pathway and Relates to Anxiety-Like Behaviors. Mayanagi T, et al. Front Cell Neurosci, 2019. PMID 31969804, Free PMC Article
    2. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. Mayanagi T, et al. J Neurosci, 2015 Oct 21. PMID 26490870, Free PMC Article
    3. Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis. Baffa R, et al. Carcinogenesis, 2008 Apr. PMID 18192690
    4. Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development. Kawaue T, et al. Nat Commun, 2019 Jun 25. PMID 31239441, Free PMC Article
    5. Timing is everything: regulation of Cdk1 and aneuploidy. Tsichlis PN, et al. Dev Cell, 2007 Apr. PMID 17419986

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lzts1 functions as a master modulator of cellular dynamics, contributing to increasing complexity of the cerebral architecture during evolution.
      Title: Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development.
    2. The results of this study provide a novel Rap2-specific regulatory mechanism in synaptic maturation involving PSD-Zip70.
      Title: PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
    3. Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
      Title: The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development.
    4. Loss of one or both LZTS1 alleles hampers the normal defenses of urothelial cells against carcinogens, favoring bladder cancer development, which may make FEZ1 a target for gene therapy.
      Title: Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis.
    5. Lzts1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice.
      Title: Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
    6. Partial or complete loss of Lzts1 downregulates Cdc25C and inhibits Cdk1 activity during mitosis, leading to premature transition from metaphase to anaphase.
      Title: Timing is everything: regulation of Cdk1 and aneuploidy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 1
    Names
    F37 esophageal cancer-related leucine zipper motif 1
    F37/Esophageal cancer-related gene-coding leucine-zipper motif
    leucine-zipper protein FEZ1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370971.1 → NP_001357900.1  leucine zipper putative tumor suppressor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC114995
      Consensus CDS
      CCDS22345.1
      UniProtKB/Swiss-Prot
      B2RTI1, P60853
      UniProtKB/TrEMBL
      A0PJT4
      Related
      ENSMUSP00000139117.2, ENSMUST00000185176.8
      Conserved Domains (2) summary
      COG1196
      Location:210 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 567
      Fez1

    2. NM_199364.3 → NP_955396.2  leucine zipper putative tumor suppressor 1

      See identical proteins and their annotated locations for NP_955396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC114995
      Consensus CDS
      CCDS22345.1
      UniProtKB/Swiss-Prot
      B2RTI1, P60853
      UniProtKB/TrEMBL
      A0PJT4
      Conserved Domains (2) summary
      COG1196
      Location:210 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 567
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      69585311..69636901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509608.5 → XP_006509671.1  leucine zipper putative tumor suppressor 1 isoform X1

      See identical proteins and their annotated locations for XP_006509671.1

      UniProtKB/Swiss-Prot
      B2RTI1, P60853
      UniProtKB/TrEMBL
      A0PJT4
      Conserved Domains (2) summary
      COG1196
      Location:210 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 567
      Fez1

    2. XM_030243384.2 → XP_030099244.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RTI1, P60853
      UniProtKB/TrEMBL
      A0PJT4
      Conserved Domains (2) summary
      COG1196
      Location:210 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 567
      Fez1

    3. XM_030243385.2 → XP_030099245.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RTI1, P60853
      UniProtKB/TrEMBL
      A0PJT4
      Conserved Domains (2) summary
      COG1196
      Location:210 → 480
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 567
      Fez1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60853.3 GenPept UniProtKB/Swiss-Prot:P60853

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