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    Git2 GIT ArfGAP 2 [ Mus musculus (house mouse) ]

    Gene ID: 26431, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Git2provided by MGI
    Official Full Name
    GIT ArfGAP 2provided by MGI
    Primary source
    MGI:MGI:1347053
    See related
    Ensembl:ENSMUSG00000041890 AllianceGenome:MGI:1347053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAT2; mKIAA0148; 1500036H07Rik; 5830420E16Rik; 6430510B20Rik; 9630056M03Rik; B230104M05Rik
    Summary
    Predicted to enable GTPase activator activity and metal ion binding activity. Involved in presynaptic modulation of chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral response to pain. Is active in calyx of Held. Is expressed in genitourinary system. Orthologous to human GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 38.4), lung adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 F; 5 55.99 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114865469..114912647, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114727408..114774588, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34931 Neighboring gene STARR-positive B cell enhancer ABC_E10341 Neighboring gene trichoplein, keratin filament binding Neighboring gene microRNA 7028 Neighboring gene RIKEN cDNA 4930515G01 gene Neighboring gene STARR-positive B cell enhancer ABC_E3602 Neighboring gene ankyrin repeat domain 13a Neighboring gene STARR-positive B cell enhancer ABC_E3603 Neighboring gene STARR-seq mESC enhancer starr_14089 Neighboring gene RIKEN cDNA 1500011B03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories. van Gastel J, et al. Mech Ageing Dev, 2019 Dec. PMID 31574270
    2. Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Siddiqui S, et al. Aging (Albany NY), 2017 Mar 4. PMID 28260693, Free PMC Article
    3. GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging. Martin B, et al. Front Endocrinol (Lausanne), 2015. PMID 26834700, Free PMC Article
    4. GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice. Hao YE, et al. FEBS Open Bio, 2015. PMID 26380813, Free PMC Article
    5. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Wang X, et al. Biochem Biophys Res Commun, 2012 Aug 24. PMID 22846567, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2.
      Title: Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2.
    2. A similar number of both total and gender-unique transcripts were significantly altered in response to GIT2 heterozygosity in early life-stage (2 month-old) mice
      Title: Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories.
    3. GIT2(-/-) mice present a prematurely distorted thymic structure and dysfunction compared to age-matched 12 month-old wild-type control (C57BL/6) mice.
      Title: Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.
    4. GIT2 plays an important role in MRE11/ATM/H2AX-mediated DNA damage responses.
      Title: Nuclear GIT2 is an ATM substrate and promotes DNA repair.
    5. GIT2 is an essential terminator of TLR signaling and loss of GIT2 leads to uncontrolled inflammation and severe organ damage
      Title: The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
    6. these findings underscore the importance of the cytoskeleton in both osteoblast and osteoclast function and demonstrate that GIT2 plays essential roles in skeletal metabolism, affecting both bone formation and bone resorption in vivo.
      Title: The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.
    7. GIT2 has a key role in regulating the chemokine-mediated motility of double-positive thymocytes
      Title: Regulation of thymocyte positive selection and motility by GIT2.
    8. Results suggest that paxillin-kinase-linker is an integral component of growth factor and cell adhesion cross-talk signaling, controlling the development of front-rear cell polarity and directional cell migration.
      Title: Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration.
    9. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
      Title: Anxiety-like behaviors in mice lacking GIT2.
    10. Analysis of endogenous GIT expression revealed a nearly ubiquitous distribution of GIT2, whereas GIT1 is restricted to specific cell types even in tissues with apparently high GIT1 expression and is entirely absent from some tissues.
      Title: Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral response to pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in calyx of Held IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in calyx of Held IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ARF GTPase-activating protein GIT2
    Names
    ARF GAP GIT2
    ARF GTPase activating protein 2
    G protein-coupled receptor kinase-interactor 2
    GRK-interacting protein 2
    cool-interacting tyrosine-phosphorylated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077359.2 → NP_001070827.1  ARF GTPase-activating protein GIT2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087330
      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:267 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:559 → 673
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    2. NM_001077360.2 → NP_001070828.1  ARF GTPase-activating protein GIT2 isoform 3

      See identical proteins and their annotated locations for NP_001070828.1

      Status: VALIDATED

      Source sequence(s)
      AC087330
      Consensus CDS
      CCDS39223.1
      UniProtKB/TrEMBL
      J3QK07, Q6PGJ1, Q80XR8
      Related
      ENSMUSP00000039718.8, ENSMUST00000043283.14
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:558 → 672
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    3. NM_001347400.2 → NP_001334329.1  ARF GTPase-activating protein GIT2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087330
      Consensus CDS
      CCDS84939.1
      UniProtKB/TrEMBL
      E9PVA6, J3QK07
      Related
      ENSMUSP00000083754.5, ENSMUST00000086564.11

    4. NM_001429058.1 → NP_001415987.1  ARF GTPase-activating protein GIT2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087330

    5. NM_001429059.1 → NP_001415988.1  ARF GTPase-activating protein GIT2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087330

    6. NM_001429060.1 → NP_001415989.1  ARF GTPase-activating protein GIT2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087330

    7. NM_001429061.1 → NP_001415990.1  ARF GTPase-activating protein GIT2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087330

    8. NM_001429062.1 → NP_001415991.1  ARF GTPase-activating protein GIT2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC087330

    9. NM_001429063.1 → NP_001415992.1  ARF GTPase-activating protein GIT2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC087330

    10. NM_001429064.1 → NP_001415993.1  ARF GTPase-activating protein GIT2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC087330

    11. NM_001429065.1 → NP_001415994.1  ARF GTPase-activating protein GIT2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC087330

    12. NM_001429066.1 → NP_001415995.1  ARF GTPase-activating protein GIT2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC087330

    13. NM_001429067.1 → NP_001415996.1  ARF GTPase-activating protein GIT2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC087330

    14. NM_001429068.1 → NP_001415997.1  ARF GTPase-activating protein GIT2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC087330

    15. NM_001429069.1 → NP_001415998.1  ARF GTPase-activating protein GIT2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC087330

    16. NM_001429070.1 → NP_001415999.1  ARF GTPase-activating protein GIT2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC087330

    17. NM_001429071.1 → NP_001416000.1  ARF GTPase-activating protein GIT2 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AC087330

    18. NM_001429072.1 → NP_001416001.1  ARF GTPase-activating protein GIT2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AC087330

    19. NM_001429073.1 → NP_001416002.1  ARF GTPase-activating protein GIT2 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AC087330

    20. NM_001429074.1 → NP_001416003.1  ARF GTPase-activating protein GIT2 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AC087330

    21. NM_001429075.1 → NP_001416004.1  ARF GTPase-activating protein GIT2 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AC087330

    22. NM_001429076.1 → NP_001416005.1  ARF GTPase-activating protein GIT2 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AC087330

    23. NM_001429077.1 → NP_001416006.1  ARF GTPase-activating protein GIT2 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AC087330

    24. NM_001429078.1 → NP_001416007.1  ARF GTPase-activating protein GIT2 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AC087330

    25. NM_001429079.1 → NP_001416008.1  ARF GTPase-activating protein GIT2 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AC087330

    26. NM_001429080.1 → NP_001416009.1  ARF GTPase-activating protein GIT2 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AC087330

    27. NM_001429081.1 → NP_001416010.1  ARF GTPase-activating protein GIT2 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AC087330

    28. NM_001429082.1 → NP_001416011.1  ARF GTPase-activating protein GIT2 isoform 29

      Status: VALIDATED

      Source sequence(s)
      AC087330

    29. NM_001429083.1 → NP_001416012.1  ARF GTPase-activating protein GIT2 isoform 30

      Status: VALIDATED

      Source sequence(s)
      AC087330

    30. NM_001429084.1 → NP_001416013.1  ARF GTPase-activating protein GIT2 isoform 31

      Status: VALIDATED

      Source sequence(s)
      AC087330

    31. NM_001429085.1 → NP_001416014.1  ARF GTPase-activating protein GIT2 isoform 32

      Status: VALIDATED

      Source sequence(s)
      AC087330

    32. NM_001429086.1 → NP_001416015.1  ARF GTPase-activating protein GIT2 isoform 33

      Status: VALIDATED

      Source sequence(s)
      AC087330

    33. NM_001429087.1 → NP_001416016.1  ARF GTPase-activating protein GIT2 isoform 34

      Status: VALIDATED

      Source sequence(s)
      AC087330

    34. NM_019834.4 → NP_062808.3  ARF GTPase-activating protein GIT2 isoform 1

      See identical proteins and their annotated locations for NP_062808.3

      Status: VALIDATED

      Source sequence(s)
      AC087330
      Consensus CDS
      CCDS19570.2
      UniProtKB/Swiss-Prot
      E9QPU7, Q9JLQ2
      UniProtKB/TrEMBL
      J3QK07
      Related
      ENSMUSP00000107803.3, ENSMUST00000112185.9
      Conserved Domains (6) summary
      smart00105
      Location:2 → 124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:109 → 220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:587 → 701
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      114865469..114912647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530331.4 → XP_006530394.1  ARF GTPase-activating protein GIT2 isoform X2

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:267 → 295
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:639 → 753
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:415 → 479
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    2. XM_006530334.4 → XP_006530397.1  ARF GTPase-activating protein GIT2 isoform X4

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:625 → 739
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:416 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    3. XM_006530335.4 → XP_006530398.1  ARF GTPase-activating protein GIT2 isoform X7

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:610 → 724
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:416 → 480
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    4. XM_006530339.4 → XP_006530402.1  ARF GTPase-activating protein GIT2 isoform X1

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:640 → 754
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:416 → 480
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    5. XM_030254527.1 → XP_030110387.1  ARF GTPase-activating protein GIT2 isoform X17

      UniProtKB/TrEMBL
      J3QK07
      Related
      ENSMUSP00000136796.2, ENSMUST00000178440.8
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:557 → 671
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_030254522.2 → XP_030110382.1  ARF GTPase-activating protein GIT2 isoform X6

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:622 → 736
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413 → 462
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    7. XM_006530333.5 → XP_006530396.1  ARF GTPase-activating protein GIT2 isoform X3

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:637 → 751
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413 → 477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    8. XM_017320893.3 → XP_017176382.1  ARF GTPase-activating protein GIT2 isoform X12

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:588 → 702
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_030254520.2 → XP_030110380.1  ARF GTPase-activating protein GIT2 isoform X5

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:623 → 737
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 463
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    10. XM_006530336.5 → XP_006530399.1  ARF GTPase-activating protein GIT2 isoform X8

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:266 → 294
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:608 → 722
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:414 → 478
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    11. XM_006530338.5 → XP_006530401.1  ARF GTPase-activating protein GIT2 isoform X16

      UniProtKB/TrEMBL
      D3Z1I2, J3QK07
      Related
      ENSMUSP00000107801.2, ENSMUST00000112183.8
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:560 → 674
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_006530337.5 → XP_006530400.1  ARF GTPase-activating protein GIT2 isoform X11

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (5) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:590 → 704
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_030254524.2 → XP_030110384.1  ARF GTPase-activating protein GIT2 isoform X10

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:268 → 296
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:595 → 709
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:416 → 465
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    14. XM_030254526.2 → XP_030110386.1  ARF GTPase-activating protein GIT2 isoform X15

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:203 → 231
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:575 → 689
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:351 → 415
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    15. XM_036165144.1 → XP_036021037.1  ARF GTPase-activating protein GIT2 isoform X14

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:204 → 232
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:574 → 690
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:352 → 416
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    16. XM_030254525.2 → XP_030110385.1  ARF GTPase-activating protein GIT2 isoform X13

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (6) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:206 → 234
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:578 → 692
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:354 → 418
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor

    17. XM_030254529.2 → XP_030110389.1  ARF GTPase-activating protein GIT2 isoform X19

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (5) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:203 → 231
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:525 → 639
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)

    18. XM_030254530.2 → XP_030110390.1  ARF GTPase-activating protein GIT2 isoform X20

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (5) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:204 → 232
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:496 → 610
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)

    19. XM_030254528.2 → XP_030110388.1  ARF GTPase-activating protein GIT2 isoform X18

      UniProtKB/TrEMBL
      J3QK07
      Conserved Domains (5) summary
      sd00045
      Location:75 → 103
      ANK; ANK repeat [structural motif]
      cl28907
      Location:1 → 49
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam08518
      Location:204 → 232
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:526 → 640
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:75 → 167
      Ank_2; Ankyrin repeats (3 copies)

    20. XM_030254523.2 → XP_030110383.1  ARF GTPase-activating protein GIT2 isoform X9

      UniProtKB/TrEMBL
      J3QK07
      Related
      ENSMUSP00000122302.3, ENSMUST00000155908.8
      Conserved Domains (6) summary
      sd00045
      Location:137 → 165
      ANK; ANK repeat [structural motif]
      cd08847
      Location:1 → 111
      ArfGap_GIT2; GIT2 GTPase activating protein for Arf
      pfam08518
      Location:265 → 293
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:607 → 721
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137 → 229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:413 → 477
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLQ2.2 GenPept UniProtKB/Swiss-Prot:Q9JLQ2

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