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    TRIP12 thyroid hormone receptor interactor 12 [ Homo sapiens (human) ]

    Gene ID: 9320, updated on 9-Jun-2024

    Summary

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    Official Symbol
    TRIP12provided by HGNC
    Official Full Name
    thyroid hormone receptor interactor 12provided by HGNC
    Primary source
    HGNC:HGNC:12306
    See related
    Ensembl:ENSG00000153827 MIM:604506; AllianceGenome:HGNC:12306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ULF; MRD49; TRIPC; TRIP-12
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
    Expression
    Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIP12 in Genome Data Viewer
    Location:
    2q36.3
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (229763837..229923186, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230246527..230405874, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230628553..230787902, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene delta/notch like EGF repeat containing Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105373923 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230488203-230488702 Neighboring gene RNA, U7 small nuclear 9 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579179-230579953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579954-230580727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230591371-230591872 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:230608102-230608922 Neighboring gene MPRA-validated peak4073 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230715552-230716230 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230714872-230715551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230765063-230765564 Neighboring gene MPRA-validated peak4074 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17205 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230785780-230786280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230786281-230786781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230808542-230809042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230817679-230818543 Neighboring gene uncharacterized LOC105373924 Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene F-box protein 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Episignature Mapping of TRIP12 Provides Functional Insight into Clark-Baraitser Syndrome. van der Laan L, et al. Int J Mol Sci, 2022 Nov 8. PMID 36430143, Free PMC Article
    2. The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2. Lee KK, et al. Cell Death Discov, 2021 May 7. PMID 33963176, Free PMC Article
    3. Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations. Donoghue T, et al. Am J Med Genet A, 2020 Jul. PMID 32424948
    4. The E3 ubiquitin ligase TRIP12 participates in cell cycle progression and chromosome stability. Larrieu D, et al. Sci Rep, 2020 Jan 21. PMID 31964993, Free PMC Article
    5. Clark-Baraitser syndrome is associated with a nonsense alteration in the autosomal gene TRIP12. Louie RJ, et al. Am J Med Genet A, 2020 Mar. PMID 31814248

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The neurodevelopmental and facial phenotype in individuals with a TRIP12 variant.
      Title: The neurodevelopmental and facial phenotype in individuals with a TRIP12 variant.
    2. Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.
      Title: Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.
    3. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth.
      Title: Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth.
    4. Episignature Mapping of TRIP12 Provides Functional Insight into Clark-Baraitser Syndrome.
      Title: Episignature Mapping of TRIP12 Provides Functional Insight into Clark-Baraitser Syndrome.
    5. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.
      Title: TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.
    6. TRIP12 has an inhibitory role in Epithelial-Mesenchymal Transition (EMT) and possibly, metastasis
      Title: The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
    7. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
      Title: The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
    8. Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
      Title: Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
    9. Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
      Title: Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
    10. TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
      Title: TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Clark-Baraitser syndrome
    MedGen: C2931130 OMIM: 617752 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-04-02)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2018-04-02)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46626, KIAA0045, MGC138849, MGC138850

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin boundary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    E3 ubiquitin-protein ligase for Arf
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    probable E3 ubiquitin-protein ligase TRIP12
    thyroid receptor interacting protein 12
    NP_001271143.1
    NP_001271144.1
    NP_001271145.1
    NP_001335244.1
    NP_001335245.1
    NP_001335246.1
    NP_001335247.1
    NP_001335248.1
    NP_001335249.1
    NP_001335250.1
    NP_001335251.1
    NP_001335252.1
    NP_001335253.1
    NP_001335254.1
    NP_001335255.1
    NP_001335256.1
    NP_001335257.1
    NP_001335258.1
    NP_001335259.1
    NP_001335260.1
    NP_001335261.1
    NP_001335262.1
    NP_001335263.1
    NP_001335264.1
    NP_001335265.1
    NP_004229.1
    XP_005247018.1
    XP_016860772.1
    XP_016860779.1
    XP_047302309.1
    XP_047302310.1
    XP_047302311.1
    XP_047302312.1
    XP_047302314.1
    XP_047302316.1
    XP_047302317.1
    XP_047302318.1
    XP_047302319.1
    XP_047302322.1
    XP_047302324.1
    XP_047302327.1
    XP_047302328.1
    XP_047302329.1
    XP_047302330.1
    XP_047302331.1
    XP_047302332.1
    XP_047302333.1
    XP_047302334.1
    XP_047302335.1
    XP_047302336.1
    XP_047302337.1
    XP_047302338.1
    XP_047302339.1
    XP_047302340.1
    XP_047302341.1
    XP_047302342.1
    XP_047302346.1
    XP_047302351.1
    XP_047302352.1
    XP_047302353.1
    XP_047302354.1
    XP_054200554.1
    XP_054200555.1
    XP_054200556.1
    XP_054200557.1
    XP_054200558.1
    XP_054200559.1
    XP_054200560.1
    XP_054200561.1
    XP_054200562.1
    XP_054200563.1
    XP_054200564.1
    XP_054200565.1
    XP_054200566.1
    XP_054200567.1
    XP_054200568.1
    XP_054200569.1
    XP_054200570.1
    XP_054200571.1
    XP_054200572.1
    XP_054200573.1
    XP_054200574.1
    XP_054200575.1
    XP_054200576.1
    XP_054200577.1
    XP_054200578.1
    XP_054200579.1
    XP_054200580.1
    XP_054200581.1
    XP_054200582.1
    XP_054200583.1
    XP_054200584.1
    XP_054200585.1
    XP_054200586.1
    XP_054200587.1
    XP_054200588.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053017.1 RefSeqGene

      Range
      6226..164398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001284214.2 → NP_001271143.1  E3 ubiquitin-protein ligase TRIP12 isoform a

      See identical proteins and their annotated locations for NP_001271143.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 5, encodes isoform a.
      Source sequence(s)
      AC093384, BC114556, BM677880, D28476, DB240964
      Consensus CDS
      CCDS63146.1
      UniProtKB/TrEMBL
      C9JLD7
      Related
      ENSP00000373696.4, ENST00000389044.8
      Conserved Domains (4) summary
      cd00078
      Location:1638 → 2038
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 846
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    2. NM_001284215.2 → NP_001271144.1  E3 ubiquitin-protein ligase TRIP12 isoform b

      See identical proteins and their annotated locations for NP_001271144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 6, encodes isoform b.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92963.1
      UniProtKB/TrEMBL
      C9JLD7
      Related
      ENSP00000515955.1, ENST00000704580.1
      Conserved Domains (4) summary
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      pfam10500
      Location:57 → 191
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat

    3. NM_001284216.2 → NP_001271145.1  E3 ubiquitin-protein ligase TRIP12 isoform d

      See identical proteins and their annotated locations for NP_001271145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform d.
      Source sequence(s)
      AC093384, BC113891, BM677880, D28476, DB240964
      Consensus CDS
      CCDS63145.1
      UniProtKB/TrEMBL
      C9JLD7
      Related
      ENSP00000373697.3, ENST00000389045.7
      Conserved Domains (3) summary
      smart00119
      Location:1338 → 1716
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1320 → 1720
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:463 → 528
      WWE; WWE domain

    4. NM_001348315.2 → NP_001335244.1  E3 ubiquitin-protein ligase TRIP12 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS63146.1
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1638 → 2038
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 846
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    5. NM_001348316.2 → NP_001335245.1  E3 ubiquitin-protein ligase TRIP12 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92963.1
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      pfam10500
      Location:57 → 191
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat

    6. NM_001348317.1 → NP_001335246.1  E3 ubiquitin-protein ligase TRIP12 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92962.1
      UniProtKB/TrEMBL
      A0A994J4J0, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      pfam10500
      Location:57 → 191
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat

    7. NM_001348318.2 → NP_001335247.1  E3 ubiquitin-protein ligase TRIP12 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92962.1
      UniProtKB/TrEMBL
      A0A994J4J0, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 831
      WWE; WWE domain
      pfam10500
      Location:57 → 191
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat

    8. NM_001348319.1 → NP_001335248.1  E3 ubiquitin-protein ligase TRIP12 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform f.
      Source sequence(s)
      AC009973, AC093384, AC105380
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1660 → 2060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    9. NM_001348320.2 → NP_001335249.1  E3 ubiquitin-protein ligase TRIP12 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform f.
      Source sequence(s)
      AC009973, AC093384, AC105380
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1660 → 2060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    10. NM_001348321.1 → NP_001335250.1  E3 ubiquitin-protein ligase TRIP12 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes isoform g.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92964.1
      UniProtKB/TrEMBL
      A0A994J569, C9JLD7
      Related
      ENSP00000515956.1, ENST00000704581.1
      Conserved Domains (4) summary
      cd00078
      Location:1661 → 2061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    11. NM_001348322.1 → NP_001335251.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13-17, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Related
      ENSP00000515952.1, ENST00000704577.1
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    12. NM_001348323.3 → NP_001335252.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14-17, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Related
      ENSP00000502713.1, ENST00000675903.1
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    13. NM_001348324.2 → NP_001335253.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12-13 and 15-17, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    14. NM_001348325.2 → NP_001335254.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 12-14 and 16-17, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Related
      ENSP00000502768.1, ENST00000675423.1
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    15. NM_001348326.2 → NP_001335255.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 12-15 and 17, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    16. NM_001348327.2 → NP_001335256.1  E3 ubiquitin-protein ligase TRIP12 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 12-16, encodes isoform h.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92966.1
      UniProtKB/TrEMBL
      A0A6Q8PHK0, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    17. NM_001348328.1 → NP_001335257.1  E3 ubiquitin-protein ligase TRIP12 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19 and 20, encodes the longest isoform (i).
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92965.1
      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7
      Related
      ENSP00000502271.1, ENST00000675453.1
      Conserved Domains (4) summary
      cd00078
      Location:1666 → 2066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    18. NM_001348329.2 → NP_001335258.1  E3 ubiquitin-protein ligase TRIP12 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18 and 20, encodes the longest isoform (i).
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92965.1
      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1666 → 2066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    19. NM_001348330.2 → NP_001335259.1  E3 ubiquitin-protein ligase TRIP12 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18 and 19, encodes the longest isoform (i).
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92965.1
      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1666 → 2066
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    20. NM_001348331.1 → NP_001335260.1  E3 ubiquitin-protein ligase TRIP12 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) encodes isoform j.
      Source sequence(s)
      AC009973, AC093384, AC105380
      Consensus CDS
      CCDS92961.1
      UniProtKB/TrEMBL
      A0A994J755, C9JLD7
      Related
      ENSP00000515960.1, ENST00000704585.1
      Conserved Domains (4) summary
      cd00078
      Location:1591 → 1991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 804
      WWE; WWE domain
      pfam10500
      Location:57 → 191
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:447 → 672
      Arm_3; Atypical Arm repeat

    21. NM_001348332.1 → NP_001335261.1  E3 ubiquitin-protein ligase TRIP12 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) encodes isoform k.
      Source sequence(s)
      AC009973, AC093384, AC105380
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1631 → 2031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:779 → 844
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:460 → 685
      Arm_3; Atypical Arm repeat

    22. NM_001348333.1 → NP_001335262.1  E3 ubiquitin-protein ligase TRIP12 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) encodes isoform l.
      Source sequence(s)
      AC009973, AC093384, AC105380
      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (4) summary
      cd00078
      Location:1639 → 2039
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 847
      WWE; WWE domain
      pfam10500
      Location:99 → 233
      SR-25; Nuclear RNA-splicing-associated protein
      cl25709
      Location:489 → 714
      Arm_3; Atypical Arm repeat

    23. NM_001348334.1 → NP_001335263.1  E3 ubiquitin-protein ligase TRIP12 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) encodes isoform n.
      Source sequence(s)
      AC009973
      UniProtKB/TrEMBL
      A0A994J7J0

    24. NM_001348335.2 → NP_001335264.1  E3 ubiquitin-protein ligase TRIP12 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
      Source sequence(s)
      AC009973
      UniProtKB/TrEMBL
      A0A994J7J0
      Related
      ENSP00000515958.1, ENST00000704583.1

    25. NM_001348336.1 → NP_001335265.1  E3 ubiquitin-protein ligase TRIP12 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
      Source sequence(s)
      AC009973
      UniProtKB/TrEMBL
      A0A994J7J0
      Related
      ENSP00000386388.1, ENST00000409677.5

    26. NM_004238.3 → NP_004229.1  E3 ubiquitin-protein ligase TRIP12 isoform c

      See identical proteins and their annotated locations for NP_004229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c.
      Source sequence(s)
      AC093384, BM677880, D28476, DB240964
      Consensus CDS
      CCDS33391.1
      UniProtKB/Swiss-Prot
      D4HL82, Q14669, Q14CA3, Q14CF1, Q15644, Q53R87, Q53TE7
      UniProtKB/TrEMBL
      C9JLD7
      Related
      ENSP00000283943.4, ENST00000283943.9
      Conserved Domains (3) summary
      smart00119
      Location:1608 → 1986
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1590 → 1990
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:760 → 798
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      229763837..229923186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446397.1 → XP_047302353.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      C9JLD7

    2. XM_047446395.1 → XP_047302351.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      C9JLD7

    3. XM_047446390.1 → XP_047302346.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      C9JLD7

    4. XM_047446384.1 → XP_047302340.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    5. XM_047446383.1 → XP_047302339.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      C9JLD7

    6. XM_047446381.1 → XP_047302337.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      C9JLD7

    7. XM_047446375.1 → XP_047302331.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      C9JLD7

    8. XM_005246961.5 → XP_005247018.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      See identical proteins and their annotated locations for XP_005247018.1

      UniProtKB/TrEMBL
      C9JLD7
      Conserved Domains (3) summary
      smart00119
      Location:1642 → 2020
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1624 → 2024
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:766 → 832
      WWE; WWE domain

    9. XM_047446379.1 → XP_047302335.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      C9JLD7

    10. XM_017005290.3 → XP_016860779.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      C9JLD7, H7C1L9
      Related
      ENSP00000400967.2, ENST00000453485.2

    11. XM_047446366.1 → XP_047302322.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      C9JLD7

    12. XM_047446373.1 → XP_047302329.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      C9JLD7

    13. XM_047446361.1 → XP_047302317.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    14. XM_017005283.3 → XP_016860772.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    15. XM_047446398.1 → XP_047302354.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      C9JLD7

    16. XM_047446396.1 → XP_047302352.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      C9JLD7

    17. XM_047446386.1 → XP_047302342.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    18. XM_047446382.1 → XP_047302338.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      C9JLD7

    19. XM_047446377.1 → XP_047302333.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A994J4J0, C9JLD7
      Related
      ENSP00000515953.1, ENST00000704578.1

    20. XM_047446376.1 → XP_047302332.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      C9JLD7

    21. XM_047446374.1 → XP_047302330.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      C9JLD7

    22. XM_047446363.1 → XP_047302319.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    23. XM_047446372.1 → XP_047302328.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    24. XM_047446360.1 → XP_047302316.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      C9JLD7

    25. XM_047446353.1 → XP_047302309.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7
      Related
      ENSP00000389827.2, ENST00000430954.6

    26. XM_047446385.1 → XP_047302341.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    27. XM_047446358.1 → XP_047302314.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      C9JLD7

    28. XM_047446356.1 → XP_047302312.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      C9JLD7

    29. XM_047446354.1 → XP_047302310.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7

    30. XM_047446380.1 → XP_047302336.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      C9JLD7

    31. XM_047446378.1 → XP_047302334.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      C9JLD7, H7C1L9

    32. XM_047446368.1 → XP_047302324.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      C9JLD7

    33. XM_047446362.1 → XP_047302318.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    34. XM_047446371.1 → XP_047302327.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    35. XM_047446355.1 → XP_047302311.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A994J569, C9JLD7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      230246527..230405874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344612.1 → XP_054200587.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      C9JLD7

    2. XM_054344610.1 → XP_054200585.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      C9JLD7

    3. XM_054344609.1 → XP_054200584.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

      UniProtKB/TrEMBL
      C9JLD7

    4. XM_054344606.1 → XP_054200581.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    5. XM_054344605.1 → XP_054200580.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

      UniProtKB/TrEMBL
      C9JLD7

    6. XM_054344603.1 → XP_054200578.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      C9JLD7

    7. XM_054344596.1 → XP_054200571.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      C9JLD7

    8. XM_054344594.1 → XP_054200569.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      C9JLD7

    9. XM_054344601.1 → XP_054200576.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      C9JLD7

    10. XM_054344600.1 → XP_054200575.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      C9JLD7, H7C1L9

    11. XM_054344588.1 → XP_054200563.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      C9JLD7

    12. XM_054344593.1 → XP_054200568.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

      UniProtKB/TrEMBL
      C9JLD7

    13. XM_054344585.1 → XP_054200560.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    14. XM_054344590.1 → XP_054200565.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    15. XM_054344613.1 → XP_054200588.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

      UniProtKB/TrEMBL
      C9JLD7

    16. XM_054344611.1 → XP_054200586.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/TrEMBL
      C9JLD7

    17. XM_054344608.1 → XP_054200583.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    18. XM_054344604.1 → XP_054200579.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      C9JLD7

    19. XM_054344598.1 → XP_054200573.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

      UniProtKB/TrEMBL
      A0A994J4J0, C9JLD7

    20. XM_054344597.1 → XP_054200572.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      C9JLD7

    21. XM_054344595.1 → XP_054200570.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

      UniProtKB/TrEMBL
      C9JLD7

    22. XM_054344587.1 → XP_054200562.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    23. XM_054344592.1 → XP_054200567.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    24. XM_054344584.1 → XP_054200559.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      C9JLD7

    25. XM_054344579.1 → XP_054200554.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7

    26. XM_054344607.1 → XP_054200582.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      C9JLD7

    27. XM_054344583.1 → XP_054200558.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

      UniProtKB/TrEMBL
      C9JLD7

    28. XM_054344582.1 → XP_054200557.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      C9JLD7

    29. XM_054344580.1 → XP_054200555.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PGG9, C9JLD7

    30. XM_054344602.1 → XP_054200577.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

      UniProtKB/TrEMBL
      C9JLD7

    31. XM_054344599.1 → XP_054200574.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

      UniProtKB/TrEMBL
      C9JLD7, H7C1L9

    32. XM_054344589.1 → XP_054200564.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      C9JLD7

    33. XM_054344586.1 → XP_054200561.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

      UniProtKB/TrEMBL
      C9JLD7

    34. XM_054344591.1 → XP_054200566.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      C9JLD7

    35. XM_054344581.1 → XP_054200556.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

      UniProtKB/TrEMBL
      A0A994J569, C9JLD7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14669.1 GenPept UniProtKB/Swiss-Prot:Q14669

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