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    Wdr33 WD repeat domain 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307524, updated on 19-May-2024

    Summary

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    Official Symbol
    Wdr33provided by RGD
    Official Full Name
    WD repeat domain 33provided by RGD
    Primary source
    RGD:1309230
    See related
    AllianceGenome:RGD:1309230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mRNA polyadenylation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human WDR33 (WD repeat domain 33). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 162.1), Kidney (RPKM 151.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr33 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23706708..23812985)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23432233..23535460)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24584832..24689681)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910201 Neighboring gene AMMECR1 like Neighboring gene small nucleolar RNA SNORA21 Neighboring gene RNA polymerase II subunit D Neighboring gene SFT2 domain containing 3 Neighboring gene uncharacterized LOC120098222 Neighboring gene LIM zinc finger domain containing 2 Neighboring gene G protein-coupled receptor 17 Neighboring gene myosin VIIb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner. Ito S, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162572
    2. Pre-mRNA 3'-end processing complex assembly and function. Chan S, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21957020, Free PMC Article
    3. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA 3' end processing protein WDR33
    Names
    WD repeat-containing protein 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107398.2 → NP_001100868.2  pre-mRNA 3' end processing protein WDR33

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      F1LT09
      Conserved Domains (5) summary
      pfam01391
      Location:717 → 769
      Collagen; Collagen triple helix repeat (20 copies)
      COG2319
      Location:121 → 405
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:121 → 402
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam09606
      Location:565 → 972
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      sd00039
      Location:122 → 159
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      23706708..23812985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277379.1 → XP_063133449.1  pre-mRNA 3' end processing protein WDR33 isoform X1

    2. XM_063277380.1 → XP_063133450.1  pre-mRNA 3' end processing protein WDR33 isoform X2

    3. XM_063277381.1 → XP_063133451.1  pre-mRNA 3' end processing protein WDR33 isoform X3

    4. XM_063277382.1 → XP_063133452.1  pre-mRNA 3' end processing protein WDR33 isoform X4

    5. XM_063277384.1 → XP_063133454.1  pre-mRNA 3' end processing protein WDR33 isoform X6

    6. XM_063277383.1 → XP_063133453.1  pre-mRNA 3' end processing protein WDR33 isoform X5

    7. XM_063277385.1 → XP_063133455.1  pre-mRNA 3' end processing protein WDR33 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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