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    usp37 ubiquitin specific peptidase 37 [ Danio rerio (zebrafish) ]

    Gene ID: 768201, updated on 19-Jun-2024

    Summary

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    Official Symbol
    usp37provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 37provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-802
    See related
    Ensembl:ENSDARG00000040990 AllianceGenome:ZFIN:ZDB-GENE-061013-802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi15b04; wu:fi15b04; wu:fi38d03; zgc:152882; zgc:153999
    Summary
    Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP37 (ubiquitin specific peptidase 37). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See usp37 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (715737..746168, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (716104..746558, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene ybeY metalloendoribonuclease Neighboring gene insulin induced gene 2 Neighboring gene uncharacterized LOC101883921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Waterborne exposure of adult zebrafish to silver nanoparticles and to ionic silver results in differential silver accumulation and effects at cellular and molecular levels. Lacave JM, et al. Sci Total Environ, 2018 Nov 15. PMID 30045502
    2. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153999

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within central nervous system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cranial skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 37
    Names
    deubiquitinating enzyme 37
    ubiquitin thioesterase 37
    ubiquitin thiolesterase 37
    ubiquitin-specific-processing protease 37
    usp39
    NP_001070811.1
    XP_009302661.1
    XP_017213213.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077343.1 → NP_001070811.1  ubiquitin carboxyl-terminal hydrolase 37

      See identical proteins and their annotated locations for NP_001070811.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124596
      UniProtKB/Swiss-Prot
      A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
      Related
      ENSDARP00000110966.3, ENSDART00000129632.3
      Conserved Domains (3) summary
      cd02257
      Location:323 → 582
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd13312
      Location:8 → 111
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:323 → 582
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      715737..746168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304386.3 → XP_009302661.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

      UniProtKB/Swiss-Prot
      A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
      UniProtKB/TrEMBL
      A0A8M3AVM6
      Conserved Domains (3) summary
      cd02257
      Location:323 → 582
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cd13312
      Location:8 → 111
      PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
      pfam00443
      Location:323 → 582
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_017357724.2 → XP_017213213.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

      UniProtKB/Swiss-Prot
      A1L1F9, E7F6T8, E7FBK6, F1QUQ3, Q08BR8
      UniProtKB/TrEMBL
      A0A8M6Z0Y8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E7F6T8.1 GenPept UniProtKB/Swiss-Prot:E7F6T8

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