ap1b1 adaptor related protein complex 1 subunit beta 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ap1b1provided by ZNC
Official Full Name: adaptor related protein complex 1 subunit beta 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-061025-1
See related: Ensembl:ENSDARG00000020621 AllianceGenome:ZFIN:ZDB-GENE-061025-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa11e04; wu:fa11e04; si:ch211-149d1.1
Summary: Predicted to enable clathrin binding activity. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception; regulation of sodium ion transmembrane transporter activity; and sensory organ development. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Is expressed in brain; eye; female organism; inner ear; and otic vesicle. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24756494..24812801, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (24252696..24309001, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Na(+)/K(+)-ATPase pump (NKA) was less abundant in the basolateral membrane and was mislocalized to apical bundles in ap1b1 mutant hair cells.
Title: Mutations in ap1b1 cause mistargeting of the Na(+)/K(+)-ATPase pump in sensory hair cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AI641040 (e-PCR)
- UniSTS:206116

fa11e04.s1 (e-PCR)
- UniSTS:202308

fc18c08.x1 (e-PCR)
- UniSTS:192849

fc18c08.x1 (e-PCR)
- UniSTS:192850

fb63a02 (e-PCR)
- UniSTS:189032

fa16c06.s1 (e-PCR)
- UniSTS:202396

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables clathrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of sodium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AP-1 complex subunit beta-1

Names: adaptor-related protein complex 1, beta 1 subunit; skb; skylab

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128530.1 → NP_001122002.1 AP-1 complex subunit beta-1

Status: PROVISIONAL

Source sequence(s)

BX664747

UniProtKB/TrEMBL

A0A8M1NHM4, A5PMS9

Related

ENSDARP00000122116.1, ENSDART00000137128.3

Conserved Domains (5) summary

smart00809
Location:727 → 827

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:836 → 946

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region

pfam12717
Location:99 → 268

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

24756494..24812801 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301345.3 → XP_009299620.1 AP-1 complex subunit beta-1 isoform X4

UniProtKB/TrEMBL

A0A8M3B9I1

Related

ENSDARP00000148745.1, ENSDART00000182415.1

Conserved Domains (5) summary

smart00809
Location:756 → 856

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:865 → 978

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:11 → 534

Adaptin_N; Adaptin N terminal region

pfam12717
Location:99 → 268

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:51 → 75

HEAT; HEAT repeat [structural motif]
XM_005165167.3 → XP_005165224.1 AP-1 complex subunit beta-1 isoform X6

UniProtKB/TrEMBL

A0A8M2BCC8

Conserved Domains (5) summary

smart00809
Location:743 → 843

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:852 → 965

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region

pfam12717
Location:115 → 284

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]
XM_009301344.3 → XP_009299619.1 AP-1 complex subunit beta-1 isoform X3

UniProtKB/TrEMBL

A0A8M3AS47

Conserved Domains (5) summary

smart00809
Location:765 → 865

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:874 → 987

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region

pfam12717
Location:115 → 284

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]
XM_021476252.1 → XP_021331927.1 AP-1 complex subunit beta-1 isoform X5

UniProtKB/TrEMBL

A0A8M9PKD8

Conserved Domains (4) summary

smart00809
Location:750 → 850

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:859 → 972

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region
XM_005165166.3 → XP_005165223.1 AP-1 complex subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8M2BCE3

Conserved Domains (5) summary

smart00809
Location:772 → 872

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:881 → 991

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region

pfam12717
Location:115 → 284

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]
XM_009301343.3 → XP_009299618.1 AP-1 complex subunit beta-1 isoform X1

UniProtKB/TrEMBL

A0A8M3AZG4

Conserved Domains (5) summary

smart00809
Location:772 → 872

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:881 → 994

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region

pfam12717
Location:115 → 284

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]
XM_005165168.3 → XP_005165225.1 AP-1 complex subunit beta-1 isoform X7

UniProtKB/TrEMBL

A0A8M2BCH0

Related

ENSDARP00000155946.1, ENSDART00000190898.1

Conserved Domains (5) summary

smart00809
Location:743 → 843

Alpha_adaptinC2; Adaptin C-terminal domain

smart01020
Location:852 → 962

B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

pfam01602
Location:27 → 550

Adaptin_N; Adaptin N terminal region

pfam12717
Location:115 → 284

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:67 → 91

HEAT; HEAT repeat [structural motif]