Lrrn2 leucine rich repeat neuronal 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrn2provided by RGD
Official Full Name: leucine rich repeat neuronal 2provided by RGD
Primary source: RGD:1305482
See related: Ensembl:ENSRNOG00000009691 AllianceGenome:RGD:1305482
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 81.7), Adrenal (RPKM 14.0) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (46874048..46934544)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (44321944..44382454)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (49660356..49730275)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH137657 (e-PCR)
- UniSTS:219744

BF386712 (e-PCR)
- UniSTS:243825

BE117324 (e-PCR)
- UniSTS:261803

BF390705 (e-PCR)
- UniSTS:249537

RH142373 (e-PCR)
- UniSTS:231620

D13Got22 (e-PCR)
- UniSTS:111846

Lrrn2 (e-PCR), detects polymorphism
- UniSTS:525561

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat neuronal protein 2

Names: leucine rich repeat protein 2, neuronal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177368.1 → NP_001170839.1 leucine-rich repeat neuronal protein 2 precursor

See identical proteins and their annotated locations for NP_001170839.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6IC64, D3ZAV8

Related

ENSRNOP00000097330.1, ENSRNOT00000106270.1

Conserved Domains (7) summary

cd00116
Location:46 → 288

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

pfam07679
Location:430 → 514

I-set; Immunoglobulin I-set domain

sd00031
Location:337 → 360

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:95 → 118

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:117 → 177

LRR_8; Leucine rich repeat

cl11960
Location:438 → 514

Ig; Immunoglobulin domain

cl15307
Location:369 → 412

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain