Itga1 integrin subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga1provided by RGD
Official Full Name: integrin subunit alpha 1provided by RGD
Primary source: RGD:2923
See related: Ensembl:ENSRNOG00000053550 AllianceGenome:RGD:2923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables collagen binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; and vasodilation. Located in several cellular components, including acrosomal vesicle; external side of plasma membrane; and perikaryon. Orthologous to human ITGA1 (integrin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 394.0), Adrenal (RPKM 382.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (48379181..48545336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (46646125..46812237, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (47127403..47281387, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

periodic mechanical stress induced ECM expression and the migration of NP cells via upregulating the expression of integrin alpha1 and the phosphorylation of downstream PLCgamma1. These findings provide novel information to aid the understanding of the pathogenesis and development of IDD.
Title: Periodic mechanical stress induces the extracellular matrix expression and migration of rat nucleus pulposus cells by upregulating the expression of intergrin α1 and phosphorylation of downstream phospholipase Cγ1.
This study shows that E2 protects against apoptosis in a time-dependent manner, and alpha1 integrin-mediated adhesion to collagen II is essential for estrogen-dependent anti-apoptosis in rat annulus fibrosus cells in vitro.
Title: 17β-Estradiol Protects Rat Annulus Fibrosus Cells Against Apoptosis via α1 Integrin-Mediated Adhesion to Type I Collagen: An In-vitro Study.
Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects on vascular smooth muscle cell proliferation/migration.
Title: Alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells.
Dynamic structural changes are observed upon collagen and metal ion binding to the integrin alpha1 I domain.
Title: Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.
Alpha(1)beta(1)-integrin has a key role in flow (shear stress)-dependent vasodilation in resistance arteries by transmitting the signal to eNOS through activation of PI3-kinase and Akt.
Title: Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries.
Pretreatment of mature hippocampal neurons with either echistatin or alpha(1) integrin-blocking antibodies prevented beta-amyloid-induced MAPK activation. The blockage of alpha(1) activation prevented cell death induced by beta-amyloid.
Title: alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons.
After spinal cord contusion, the area of alpha1beta1 integrin positive blood vessels increases within 11 mm from the injury site at 3 days post-injury and remains prominent within the injured core only at 7 days.
Title: Developmental and injury-induced expression of alpha1beta1 and alpha6beta1 integrins in the rat spinal cord.
Data suggest that endothelin-1 promotes collagen matrix reorganization through the enhancement of mesangial cell alpha1beta1 integrin-dependent migration and MMP-2 activity.
Title: Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130277 (e-PCR)
- UniSTS:213564

Itga1 (e-PCR), detects polymorphism
- UniSTS:143608

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables collagen binding involved in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular extravasation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
part_of integrin alpha1-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin alpha-1

Names: CD49 antigen-like family member A; VLA-1; laminin and collagen receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030994.2 → NP_112256.1 integrin alpha-1 precursor

See identical proteins and their annotated locations for NP_112256.1

Status: PROVISIONAL

Source sequence(s)

X52140

UniProtKB/Swiss-Prot

P18614

UniProtKB/TrEMBL

A0A8L2R8Q8, A6I5T3

Related

ENSRNOP00000086956.1, ENSRNOT00000106157.1

Conserved Domains (3) summary

smart00191
Location:567 → 620

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:171 → 351

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:663 → 1073

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

48379181..48545336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101763.2 → XP_038957691.1 integrin alpha-1 isoform X1

UniProtKB/TrEMBL

A0A8L2R8Q8

Conserved Domains (3) summary

smart00191
Location:567 → 620

Int_alpha; Integrin alpha (beta-propellor repeats)

cd01469
Location:171 → 351

vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...

pfam08441
Location:663 → 1004

Integrin_alpha2; Integrin alpha