Abcb10 ATP-binding cassette, sub-family B member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcb10provided by MGI
Official Full Name: ATP-binding cassette, sub-family B member 10provided by MGI
Primary source: MGI:MGI:1860508
See related: Ensembl:ENSMUSG00000031974 AllianceGenome:MGI:1860508
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abc-me; Abcb12
Summary: This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
Expression: Broad expression in liver E14.5 (RPKM 58.9), liver E14 (RPKM 57.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 72.31 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (124679198..124709877, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (123952459..123983122, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4.
Title: Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4.
Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.
Title: Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance.
ABCB10 Loss Reduces CD4(+) T Cell Activation and Memory Formation.
Title: ABCB10 Loss Reduces CD4(+) T Cell Activation and Memory Formation.
Study demonstrates a mechanism of ABCB10 regulation driven by NF-E2 related factor-2 (Nrf2). In summary, Nrf2 dysregulation and ABCB10 suppression could likely mediate endothelial oxidative/inflammatory stress and BBB disruption in diabetic subjects.
Title: Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?
ATP binding and hydrolysis properties of ABCB10 by using the 8-azido-ATP photolabeling technique, was characterized.
Title: ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.
A critical role for Abcb10 in heme biosynthesis.
Title: Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation.
ABC-me deletion causes an increase in mitochondrial superoxide production and protein carbonylation in erythroid precursors.
Title: The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo.
Ferrochelatase forms an oligomeric complex with Mfrn1 and Abcb10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.
Title: Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis.
Data show that the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1.
Title: Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236033

Abcb10 (e-PCR), detects polymorphism
- UniSTS:546615

C76534 (e-PCR)
- UniSTS:159839

AU016331 (e-PCR)
- UniSTS:179848

RH125990 (e-PCR)
- UniSTS:162702

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in erythrocyte development	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family B member 10, mitochondrial

Names: ABC-mitochondrial erythroid protein; ATP-binding cassette transporter 10; ATP-binding cassette, sub-family B (MDR/TAP), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019552.2 → NP_062425.1 ATP-binding cassette sub-family B member 10, mitochondrial precursor

See identical proteins and their annotated locations for NP_062425.1

Status: REVIEWED

Source sequence(s)

BC054793

Consensus CDS

CCDS22766.1

UniProtKB/Swiss-Prot

Q542P7, Q9D0C7, Q9JI39

Related

ENSMUSP00000075011.7, ENSMUST00000075578.7

Conserved Domains (3) summary

cd03249
Location:458 → 698

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

TIGR00958
Location:8 → 694

3a01208; Conjugate Transporter-2 (CT2) Family protein

pfam00664
Location:142 → 403

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

124679198..124709877 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154190.1 → XP_036010083.1 ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

Conserved Domains (3) summary

cd03249
Location:123 → 363

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

cd07346
Location:3 → 48

ABC_6TM_exporters; TM helix 5 [structural motif]

cl38913
Location:3 → 95

ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters