Fshr follicle stimulating hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fshrprovided by RGD
Official Full Name: follicle stimulating hormone receptorprovided by RGD
Primary source: RGD:2632
See related: Ensembl:ENSRNOG00000016783 AllianceGenome:RGD:2632
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables follicle-stimulating hormone receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; follicle-stimulating hormone signaling pathway; and transcytosis. Located in cell surface and endosome. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis; ovarian dysgenesis 1; and ovarian hyperstimulation syndrome. Orthologous to human FSHR (follicle stimulating hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 10.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (10952329..11160288)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (5198825..5406785)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (12796383..12997817, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypothyroidism changes CYP51 and FSHR expression in ovary, which are regulated by gonadotropin. Moreover, genes changes in ovary are at least partially attributed to steroids biosynthesis.
Title: Effect of hypothyroidism on CYP51 and FSHR expression in rat ovary.
The results of this study support the notion that by inhibiting eIF5A hypusination, FSH reduces the expression of an LHCGR mRNA-binding protein (LRBP), and then this increases LHCGR mRNA expression by abrogating the inhibitory action of LRBP.
Title: LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.
Data indicate that sustained follicle stimulation by luteinizing hormone (LH) decreases follicle stimulating hormone (FSH) receptor mRNA levels and FSH receptor signaling and inhibits FSH-induced follicular growth.
Title: Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition.
In 20-day-old rat Sertoli cells, transmembrane cell PGs, through tethering/activation of PP2A activity exerts regulatory control on both FSH receptor/Gs coupling and ERK phosphorylation.
Title: Alteration of cell membrane proteoglycans impairs FSH receptor/Gs coupling and ERK activation through PP2A-dependent mechanisms in immature rat Sertoli cells.
Zuoguiyin could improve the ovarian functions during peri-menopause by up-regulating the expression of FSHR.
Title: [Effect of zuoguiyin on the expression of ovarian follicle-stimulating hormone receptor in rats during peri-menopausal period].
The data suggested that, during prepubertal Sertoli cell maturation, the ability of FSH receptor to respond to FSH is significantly augmented and is associated with the robust differentiation of repopulating spermatogonia.
Title: A switch in Sertoli cell responsiveness to FSH may be responsible for robust onset of germ cell differentiation during prepubartal testicular maturation in rats.
report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter
Title: Regulation of FSH receptor expression by the Wilms' tumor 1 gene product (WT1) in immature rat granulosa cells.
Used immunohistochemistry to study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, and by Western blot analysis in the caput and cauda epididymis of rat.
Title: The immunoexpression of FSH-R in the ductuli efferentes and the epididymis of men and rat: effect of FSH on the morphology and steroidogenic activity of rat epididymal epithelial cells in vitro.
A potential new regulatory mechanism of the FSH signalling pathway that could occur during maturation of testicular cells.
Title: Differential time course of FSH/FSH receptor complex endocytosis within sertoli and germ cells during rat testis development.
MyH9 constitutively forms a ternary complex with FSH-R and inactive GDP-bound G alpha h.
Title: Nonmuscle myosin IIA (myosin heavy polypeptide 9): a novel class of signal transducer mediating the activation of G alpha h/phospholipase C-delta 1 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (25)

General gene information

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Markers

FSHR (e-PCR)
- UniSTS:264013

d6mit5 (e-PCR)
- UniSTS:122189

AU046405 (e-PCR)
- UniSTS:111472

Fshr (e-PCR), detects polymorphism
- UniSTS:526969

AU027195 (e-PCR)
- UniSTS:113544

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables follicle-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables follicle-stimulating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables follicle-stimulating hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Sertoli cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Sertoli cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in follicle-stimulating hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in follicle-stimulating hormone signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular water homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovulation cycle process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within primary ovarian follicle growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of acetylcholine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hormone metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sperm DNA condensation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: follicle-stimulating hormone receptor

Names: FSH-R; follitropin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199237.2 → NP_954707.1 follicle-stimulating hormone receptor precursor

See identical proteins and their annotated locations for NP_954707.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P20395, Q64183

UniProtKB/TrEMBL

A6H9B0

Related

ENSRNOP00000022802.3, ENSRNOT00000022802.5

Conserved Domains (5) summary

smart00013
Location:23 → 50

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:72 → 96

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:378 → 625

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12369
Location:282 → 348

GnHR_trans; Gonadotropin hormone receptor transmembrane region

pfam13855
Location:72 → 132

LRR_8; Leucine rich repeat