Gopc golgi associated PDZ and coiled-coil motif containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gopcprovided by RGD
Official Full Name: golgi associated PDZ and coiled-coil motif containingprovided by RGD
Primary source: RGD:1309512
See related: Ensembl:ENSRNOG00000000408 AllianceGenome:RGD:1309512
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including frizzled binding activity; protein C-terminus binding activity; and protein homodimerization activity. Predicted to be involved in cytoplasmic sequestering of CFTR protein; negative regulation of anion channel activity; and negative regulation of protein localization to cell surface. Predicted to act upstream of or within spermatid nucleus differentiation. Predicted to be located in cytoplasm; plasma membrane; and synapse. Predicted to be part of protein-containing complex. Predicted to be active in Golgi apparatus; membrane; and trans-Golgi network transport vesicle. Orthologous to human GOPC (golgi associated PDZ and coiled-coil motif containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 113.4), Brain (RPKM 110.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (32270314..32319635, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (31727617..31776904, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (33471355..33521281, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5.
Title: The Golgi-Associated PDZ Domain Protein Gopc/PIST Is Required for Synaptic Targeting of mGluR5.
Distribution of Gopc/PIST suggests that the protein serves distinctive roles in specific neuronal populations, establishing functionally distinct zones, for instance, in the hippocampus.
Title: Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE108698 (e-PCR)
- UniSTS:247851

RH134823 (e-PCR)
- UniSTS:218101

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase regulator activity	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatid nucleus differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Golgi-associated PDZ and coiled-coil motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107631.3 → NP_001101101.2 Golgi-associated PDZ and coiled-coil motif-containing protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I5ZTW6, A0A8J8YNI6

Related

ENSRNOP00000054286.4, ENSRNOT00000057476.4

Conserved Domains (2) summary

cd00992
Location:287 → 369

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:35 → 215

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_001393720.1 → NP_001380649.1 Golgi-associated PDZ and coiled-coil motif-containing protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I5ZTW6

Related

ENSRNOP00000082400.1, ENSRNOT00000110578.1

Conserved Domains (2) summary

PRK09039
Location:46 → 215

PRK09039; peptidoglycan -binding protein

cd00992
Location:279 → 361

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...