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    Prss36 serine protease 36 [ Mus musculus (house mouse) ]

    Gene ID: 77613, updated on 12-May-2024

    Summary

    Official Symbol
    Prss36provided by MGI
    Official Full Name
    serine protease 36provided by MGI
    Primary source
    MGI:MGI:1924863
    See related
    Ensembl:ENSMUSG00000070371 AllianceGenome:MGI:1924863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330007D15Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in embryo. Orthologous to human PRSS36 (serine protease 36). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 4.9), mammary gland adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    7 F3; 7 69.84 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127531810..127545897, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127932638..127946725, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11370 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene STARR-seq mESC enhancer starr_20195 Neighboring gene K(lysine) acetyltransferase 8 Neighboring gene serine protease 8 (prostasin) Neighboring gene STARR-positive B cell enhancer ABC_E6608 Neighboring gene predicted gene, 53375 Neighboring gene STARR-seq mESC enhancer starr_20197 Neighboring gene fused in sarcoma Neighboring gene PYD and CARD domain containing

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    polyserase-2
    Names
    polyserase-2 protein
    polyserine protease 2
    protease, serine 36

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319147.1NP_001306076.1  polyserase-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS52410.2
      UniProtKB/Swiss-Prot
      Q5K2P8
      UniProtKB/TrEMBL
      E9QJT0
      Related
      ENSMUSP00000112659.2, ENSMUST00000118755.8
      Conserved Domains (4) summary
      smart00020
      Location:47287
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:48290
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00089
      Location:327457
      Trypsin; Trypsin
      cl21584
      Location:596778
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127531810..127545897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312395.3XP_017167884.1  polyserase-2 isoform X17

      UniProtKB/Swiss-Prot
      Q5K2P8
      UniProtKB/TrEMBL
      D3YV46
      Related
      ENSMUSP00000091565.4, ENSMUST00000094026.10
      Conserved Domains (2) summary
      cd00190
      Location:48290
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:607789
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_017312388.2XP_017167877.1  polyserase-2 isoform X8

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:371553
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017312387.2XP_017167876.1  polyserase-2 isoform X5

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:396578
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_036153559.1XP_036009452.1  polyserase-2 isoform X4

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:429611
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_030243097.1XP_030098957.1  polyserase-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5K2P8
      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:494676
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    6. XM_036153560.1XP_036009453.1  polyserase-2 isoform X11

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    7. XM_030243100.1XP_030098960.1  polyserase-2 isoform X7

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00089
      Location:208321
      Trypsin
    8. XM_036153561.1XP_036009454.1  polyserase-2 isoform X12

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    9. XM_030243103.1XP_030098963.1  polyserase-2 isoform X13

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    10. XM_030243101.1XP_030098961.1  polyserase-2 isoform X9

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    11. XM_030243098.1XP_030098958.1  polyserase-2 isoform X3

      UniProtKB/Swiss-Prot
      Q5K2P8
      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:487669
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    12. XM_030243099.1XP_030098959.1  polyserase-2 isoform X6

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    13. XM_030243102.1XP_030098962.1  polyserase-2 isoform X10

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    14. XM_030243095.1XP_030098955.1  polyserase-2 isoform X1

      UniProtKB/Swiss-Prot
      Q5K2P8
      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:527709
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    15. XM_030243106.1XP_030098966.1  polyserase-2 isoform X15

      Conserved Domains (1) summary
      cl21584
      Location:184366
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    16. XM_030243105.1XP_030098965.1  polyserase-2 isoform X14

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    17. XM_036153562.1XP_036009455.1  polyserase-2 isoform X16

      Conserved Domains (2) summary
      cd00190
      Location:1171
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl21584
      Location:212321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RNA

    1. XR_004934211.1 RNA Sequence

    2. XR_003946593.1 RNA Sequence

    3. XR_003946595.1 RNA Sequence

    4. XR_003946592.1 RNA Sequence

    5. XR_003946594.1 RNA Sequence

    6. XR_003946591.1 RNA Sequence

    7. XR_003946596.1 RNA Sequence

    8. XR_004934210.1 RNA Sequence

    9. XR_004934214.1 RNA Sequence

    10. XR_004934216.1 RNA Sequence

    11. XR_004934213.1 RNA Sequence

    12. XR_004934215.1 RNA Sequence

    13. XR_004934212.1 RNA Sequence

    14. XR_004934217.1 RNA Sequence

    15. XR_003946585.1 RNA Sequence

    16. XR_003946588.1 RNA Sequence

    17. XR_003946584.1 RNA Sequence

    18. XR_003946586.1 RNA Sequence

    19. XR_004934209.1 RNA Sequence

    20. XR_004934208.1 RNA Sequence

    21. XR_004934207.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081374.1: Suppressed sequence

      Description
      NM_001081374.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.