AMOTL2 angiomotin like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AMOTL2provided by HGNC
Official Full Name: angiomotin like 2provided by HGNC
Primary source: HGNC:HGNC:17812
See related: Ensembl:ENSG00000114019 MIM:614658; AllianceGenome:HGNC:17812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LCCP
Summary: Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Expression: Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q22.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (134355345..134375417, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (137100500..137120572, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (134074187..134094259, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
Title: AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
AMOTL2knockdown promotes the proliferation, migration and invasion of glioma by regulating betacatenin nuclear localization.
Title: AMOTL2‑knockdown promotes the proliferation, migration and invasion of glioma by regulating β‑catenin nuclear localization.
AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
Title: AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.
the localization of IQGAP1, AmotL2, and FKBP51 in malignant cells and tumor microenvironment of human GB tumors
Title: IQGAP1, AmotL2, and FKBP51 Scaffoldins in the Glioblastoma Microenvironment.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention
Title: Angiomotin-like 2 interacts with and negatively regulates AKT.
study reports for the first time that USP9X is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP inhibition
Title: Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition.
mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
Title: Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Scaffold proteins angiomotin (Amot) and angiomotin-related AmotL1 and AmotL2 were recently identified as negative regulators of YAP and TAZ by preventing their nuclear translocation.
Title: Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release	PubMed
	gag	Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-34138 (e-PCR)
- UniSTS:42810

AMOTL2__4299 (e-PCR)
- UniSTS:464452

RH80520 (e-PCR)
- UniSTS:86618

A002Y47 (e-PCR)
- UniSTS:11360

WI-20334 (e-PCR)
- UniSTS:55464

STS-H93486 (e-PCR)
- UniSTS:52913

SHGC-32914 (e-PCR)
- UniSTS:53735

SGC32004 (e-PCR)
- UniSTS:99817

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiomotin-like protein 2

Names: Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278683.1 → NP_001265612.1 angiomotin-like protein 2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest protein.

Source sequence(s)

AF175966, AI214560, AK299270, AW294642, BC011454

Consensus CDS

CCDS63784.1

UniProtKB/Swiss-Prot

Q9Y2J4

Related

ENSP00000424765.1, ENST00000514516.5

Conserved Domains (2) summary

pfam06156
Location:370 → 422

DUF972; Protein of unknown function (DUF972)

pfam12240
Location:540 → 741

Angiomotin_C; Angiomotin C terminal
NM_001278685.2 → NP_001265614.1 angiomotin-like protein 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus and lacks two internal amino acids compared to isoform 1.

Source sequence(s)

AF175966, AI214560, AK223598, AK299270, AW294642, BC011454, DA330301

Consensus CDS

CCDS63783.1

UniProtKB/Swiss-Prot

Q9Y2J4

Related

ENSP00000425475.1, ENST00000513145.1

Conserved Domains (2) summary

pfam06156
Location:312 → 364

DUF972; Protein of unknown function (DUF972)

pfam12240
Location:482 → 681

Angiomotin_C; Angiomotin C terminal
NM_001363943.2 → NP_001350872.1 angiomotin-like protein 2 isoform 4

Status: REVIEWED

Source sequence(s)

AC010207

Consensus CDS

CCDS87138.1

UniProtKB/Swiss-Prot

A8K6F1, B7Z5Q1, E9PHW3, Q53EP1, Q96F99, Q9UKB4, Q9Y2J4

Related

ENSP00000409999.2, ENST00000422605.6

Conserved Domains (2) summary

COG1196
Location:298 → 581

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:482 → 684

Angiomotin_C; Angiomotin C terminal
NM_016201.4 → NP_057285.3 angiomotin-like protein 2 isoform 2

See identical proteins and their annotated locations for NP_057285.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus and contains an additional internal amino acid compared to isoform 1.

Source sequence(s)

AF175966, AI214560, AK291616, AW294642, BC011454, DA330301

Consensus CDS

CCDS33860.1

UniProtKB/Swiss-Prot

Q9Y2J4

Related

ENSP00000249883.5, ENST00000249883.10

Conserved Domains (2) summary

pfam06156
Location:312 → 364

DUF972; Protein of unknown function (DUF972)

pfam12240
Location:482 → 683

Angiomotin_C; Angiomotin C terminal