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    Dcaf12 DDB1 and CUL4 associated factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 68970, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dcaf12provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 12provided by MGI
    Primary source
    MGI:MGI:1916220
    See related
    Ensembl:ENSMUSG00000028436 AllianceGenome:MGI:1916220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr40a; 1500001L20Rik; 5830424K06Rik
    Summary
    Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to be located in centrosome and cytoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF12 (DDB1 and CUL4 associated factor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.9), liver E14 (RPKM 16.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcaf12 in Genome Data Viewer
    Location:
    4 A5; 4 21.32 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41291300..41316749, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41291300..41316749, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated protein 2 Neighboring gene predicted gene 12401 Neighboring gene STARR-positive B cell enhancer ABC_E2108 Neighboring gene predicted gene, 42273 Neighboring gene STARR-positive B cell enhancer ABC_E7963 Neighboring gene STARR-positive B cell enhancer ABC_E6163 Neighboring gene predicted gene, 26049 Neighboring gene STARR-seq mESC enhancer starr_10032 Neighboring gene predicted gene, 46891 Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene predicted gene, 26084 Neighboring gene ubiquitin-associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. Lidak T, et al. Int J Mol Sci, 2021 May 20. PMID 34065512, Free PMC Article
    2. DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. Zhang YL, et al. EMBO J, 2018 Sep 14. PMID 30111536, Free PMC Article
    3. DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Wang X, et al. Cell Rep, 2021 Jun 22. PMID 34161765
    4. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 12
    Names
    WD repeat domain 40A
    WD repeat-containing protein 40A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026893.3 → NP_081169.2  DDB1- and CUL4-associated factor 12

      See identical proteins and their annotated locations for NP_081169.2

      Status: VALIDATED

      Source sequence(s)
      AA207929, AK031089, AK173289, BY338453
      Consensus CDS
      CCDS18059.1
      UniProtKB/Swiss-Prot
      Q69Z77, Q8BGZ3, Q8BN60, Q8C1Y4, Q9DB95
      Related
      ENSMUSP00000030145.9, ENSMUST00000030145.9
      Conserved Domains (3) summary
      COG2319
      Location:103 → 378
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:144 → 180
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:85 → 279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41291300..41316749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538230.4 → XP_006538293.1  DDB1- and CUL4-associated factor 12 isoform X4

      See identical proteins and their annotated locations for XP_006538293.1

    2. XM_006538229.4 → XP_006538292.1  DDB1- and CUL4-associated factor 12 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:120 → 156
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:61 → 255
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006538228.4 → XP_006538291.1  DDB1- and CUL4-associated factor 12 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:138 → 174
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:79 → 273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036164402.1 → XP_036020295.1  DDB1- and CUL4-associated factor 12 isoform X4

    5. XM_017320381.3 → XP_017175870.1  DDB1- and CUL4-associated factor 12 isoform X4

    6. XM_036164401.1 → XP_036020294.1  DDB1- and CUL4-associated factor 12 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:90 → 130
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:85 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGZ3.1 GenPept UniProtKB/Swiss-Prot:Q8BGZ3

    Gene LinkOut

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