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Rock1 Rho-associated coiled-coil containing protein kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81762, updated on 2-May-2024

Summary

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Official Symbol: Rock1provided by RGD
Official Full Name: Rho-associated coiled-coil containing protein kinase 1provided by RGD
Primary source: RGD:620424
See related: Ensembl:ENSRNOG00000031092 AllianceGenome:RGD:620424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ROCK-I; P160Rock
Summary: Enables small GTPase binding activity. Involved in cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Predicted to be located in lamellipodium; plasma membrane; and ruffle. Predicted to be part of amyloid-beta complex. Predicted to be active in cytoplasmic stress granule and cytoskeleton. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 255.8), Lung (RPKM 241.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Rock1 in Genome Data Viewer

Location:: 18p13

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (1387360..1509218, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (1114532..1236345, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (1273490..1390790, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-488-3p alleviates neuropathic pain by regulating target gene ROCK1.
Title: miR‑488‑3p alleviates neuropathic pain by regulating target gene ROCK1.
Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
Title: Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway.
miR-199a-5p Plays a Pivotal Role on Wound Healing via Suppressing VEGFA and ROCK1 in Diabetic Ulcer Foot.
Title: miR-199a-5p Plays a Pivotal Role on Wound Healing via Suppressing VEGFA and ROCK1 in Diabetic Ulcer Foot.
Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-kappaB signaling pathways.
Title: Ferulic acid attenuates non-alcoholic steatohepatitis by reducing oxidative stress and inflammation through inhibition of the ROCK/NF-κB signaling pathways.
Increased ROCK1 not ROCK2 in circulating leukocytes in rats with myocardial ischemia/reperfusion.
Title: Increased ROCK1 not ROCK2 in circulating leukocytes in rats with myocardial ischemia/reperfusion.
MicroRNA-582-5p Reduces Propofol-induced Apoptosis in Developing Neurons by Targeting ROCK1.
Title: MicroRNA-582-5p Reduces Propofol-induced Apoptosis in Developing Neurons by Targeting ROCK1.
miR-217 alleviates high-glucose-induced vascular smooth muscle cell dysfunction via regulating ROCK1.
Title: miR-217 alleviates high-glucose-induced vascular smooth muscle cell dysfunction via regulating ROCK1.
MicroRNA-23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor-kappa B crosstalk.
Title: MicroRNA-23a reduces lipopolysaccharide-induced cellular apoptosis and inflammatory cytokine production through Rho-associated kinase 1/sirtuin-1/nuclear factor-kappa B crosstalk.
MicroRNA153 attenuates hypoxiainduced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.
Title: MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3.
ROCK-TAZ signaling axis regulates mechanical tension-induced osteogenic differentiation of rat cranial sagittal suture mesenchymal stem cells.
Title: ROCK-TAZ signaling axis regulates mechanical tension-induced osteogenic differentiation of rat cranial sagittal suture mesenchymal stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (108)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rock1 (e-PCR), detects polymorphism
- UniSTS:516657

RH127505 (e-PCR)
- UniSTS:210815

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in apical constriction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apical constriction	ISO Inferred from Sequence Orthology more info
involved_in bleb assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in mRNA destabilization	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in membrane to membrane docking	IEA Inferred from Electronic Annotation more info
involved_in membrane to membrane docking	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration	IEA Inferred from Electronic Annotation more info
involved_in myoblast migration	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection arborization	IEA Inferred from Electronic Annotation more info
involved_in neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in podocyte cell migration	IEA Inferred from Electronic Annotation more info
involved_in podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of connective tissue replacement	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of connective tissue replacement	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of actin filament-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to angiotensin	IEA Inferred from Electronic Annotation more info
involved_in response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in response to transforming growth factor beta	IEA Inferred from Electronic Annotation more info
involved_in response to transforming growth factor beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of amyloid-beta complex	IEA Inferred from Electronic Annotation more info
located_in bleb	IEA Inferred from Electronic Annotation more info
located_in centriole	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho-associated protein kinase 1

Names: Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; liver regeneration-related protein LRRG199; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I

NP_001376168.1

EC 2.7.11.1

XP_006254463.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389239.1 → NP_001376168.1 rho-associated protein kinase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D4A5S0

Related

ENSRNOP00000047378.6, ENSRNOT00000051362.6

Conserved Domains (6) summary

cd11639
Location:489 → 554

HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1

cd01242
Location:1119 → 1225

PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain

cd05622
Location:2 → 406

STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

TIGR02168
Location:426 → 1097

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd22250
Location:836 → 913

ROCK_SBD; Shroom-binding domain found in Rho-associated coiled-coil containing protein kinase

cd20874
Location:1222 → 1290

C1_ROCK1; protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 1 (ROCK1) and similar proteins

RNA

NR_171200.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

1387360..1509218 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254401.5 → XP_006254463.1 rho-associated protein kinase 1 isoform X1

UniProtKB/TrEMBL

D4A5S0

Conserved Domains (7) summary

cd11639
Location:488 → 553

HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1

smart00220
Location:76 → 338

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00029
Location:1228 → 1282

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01242
Location:1118 → 1224

PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain

cd05622
Location:2 → 406

STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

TIGR02168
Location:425 → 1096

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam08912
Location:948 → 1013

Rho_Binding; Rho Binding