Wdr44 WD repeat domain 44 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wdr44provided by RGD
Official Full Name: WD repeat domain 44provided by RGD
Primary source: RGD:727965
See related: Ensembl:ENSRNOG00000029068 AllianceGenome:RGD:727965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rab11BP
Summary: Enables small GTPase binding activity. Involved in regulation of cell migration. Located in microtubule and perinuclear region of cytoplasm. Orthologous to human WDR44 (WD repeat domain 44). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 91.0), Thymus (RPKM 86.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (119286802..119392240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (114481890..114587307)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (120860178..120965918)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular sequestering activity	IEA Inferred from Electronic Annotation more info
enables molecular sequestering activity	ISO Inferred from Sequence Orthology more info
enables molecular sequestering activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytosolic ciliogenesis	IEA Inferred from Electronic Annotation more info
involved_in cytosolic ciliogenesis	ISO Inferred from Sequence Orthology more info
involved_in cytosolic ciliogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: WD repeat-containing protein 44

Names: WD-containing protein Rab11BP/Rabphilin-11; rabphilin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100823.1 → NP_001094293.1 WD repeat-containing protein 44

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2JX77, A6JMD4

Related

ENSRNOP00000070165.2, ENSRNOT00000085185.2

Conserved Domains (3) summary

COG2319
Location:499 → 825

WD40; WD40 repeat [General function prediction only]

sd00039
Location:516 → 607

7WD40; WD40 repeat [structural motif]

cl02567
Location:512 → 859

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

119286802..119392240

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099449.2 → XP_038955377.1 WD repeat-containing protein 44 isoform X1

UniProtKB/TrEMBL

A0A0G2K7S6, A6JMD4

Conserved Domains (2) summary

sd00039
Location:520 → 611

7WD40; WD40 repeat [structural motif]

cl29593
Location:516 → 863

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063279776.1 → XP_063135846.1 WD repeat-containing protein 44 isoform X2

UniProtKB/TrEMBL

A0A0G2JX77
XM_039099450.2 → XP_038955378.1 WD repeat-containing protein 44 isoform X1

UniProtKB/TrEMBL

A0A0G2K7S6, A6JMD4

Conserved Domains (2) summary

sd00039
Location:520 → 611

7WD40; WD40 repeat [structural motif]

cl29593
Location:516 → 863

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...