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    Thsd7a thrombospondin, type I, domain containing 7A [ Mus musculus (house mouse) ]

    Gene ID: 330267, updated on 12-May-2024

    Summary

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    Official Symbol
    Thsd7aprovided by MGI
    Official Full Name
    thrombospondin, type I, domain containing 7Aprovided by MGI
    Primary source
    MGI:MGI:2685683
    See related
    Ensembl:ENSMUSG00000032625 AllianceGenome:MGI:2685683
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm837
    Summary
    Involved in actin cytoskeleton reorganization. Located in plasma membrane and podocyte foot. Is expressed in several structures, including alimentary system; autopod; central nervous system; genitourinary system; and sensory organ. Orthologous to human THSD7A (thrombospondin type 1 domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.7), CNS E14 (RPKM 3.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A1; 6 5.31 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (12311607..12749252, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (12311608..12749253, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32222 Neighboring gene predicted gene, 35961 Neighboring gene STARR-seq mESC enhancer starr_15174 Neighboring gene STARR-seq mESC enhancer starr_15175 Neighboring gene STARR-seq mESC enhancer starr_15176 Neighboring gene STARR-seq mESC enhancer starr_15177 Neighboring gene predicted gene, 38583 Neighboring gene STARR-seq mESC enhancer starr_15178 Neighboring gene STARR-seq mESC enhancer starr_15179 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 11 Neighboring gene STARR-seq mESC enhancer starr_15182 Neighboring gene STARR-seq mESC enhancer starr_15184 Neighboring gene STARR-seq mESC enhancer starr_15185 Neighboring gene HORMA domain containing 1 pseudogene Neighboring gene predicted gene, 18221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The classical pathway triggers pathogenic complement activation in membranous nephropathy. Seifert L, et al. Nat Commun, 2023 Jan 28. PMID 36709213, Free PMC Article
    2. Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. Tomas NM, et al. J Clin Invest, 2016 Jul 1. PMID 27214550, Free PMC Article
    3. In situ cell-type-specific cell-surface proteomic profiling in mice. Shuster SA, et al. Neuron, 2022 Dec 7. PMID 36220098, Free PMC Article
    4. Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity. Clark EA, et al. Elife, 2020 Aug 27. PMID 32851975, Free PMC Article
    5. Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Lefebvre J, et al. Kidney Int, 2015 Aug. PMID 25993318

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podocyte foot IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thrombospondin type-1 domain-containing protein 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164805.1 → NP_001158277.1  thrombospondin type-1 domain-containing protein 7A precursor

      Status: VALIDATED

      Source sequence(s)
      AC122394, AK133324, AK136087, AK164834, BB656281, BC052230, DV653338
      Consensus CDS
      CCDS51721.1
      UniProtKB/Swiss-Prot
      Q3TP01, Q3UWV1, Q69ZU6
      UniProtKB/TrEMBL
      E9Q6P0, E9QNR5
      Related
      ENSMUSP00000113681.3, ENSMUST00000119581.7
      Conserved Domains (2) summary
      smart00209
      Location:186 → 236
      TSP1; Thrombospondin type 1 repeats
      cl15278
      Location:353 → 404
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      12311607..12749252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZU6.2 GenPept UniProtKB/Swiss-Prot:Q69ZU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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