Crebbp CREB binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crebbpprovided by RGD
Official Full Name: CREB binding proteinprovided by RGD
Primary source: RGD:2401
See related: Ensembl:ENSRNOG00000005330 AllianceGenome:RGD:2401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CBP; RTS; RSTS
Summary: Enables several functions, including SMAD binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator binding activity. Involved in several processes, including behavioral response to cocaine; long-term memory; and positive regulation of NIK/NF-kappaB signaling. Located in nuclear body. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 165.4), Spleen (RPKM 146.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (11842307..11968266)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11335551..11461888)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (11590994..11721039)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
Title: P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
CREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
Title: CREB-binding protein and HIF-1α/β-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.
Title: CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.
The data suggest that alterations of histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus and the inability of Ncoa2 and Crebbp to respond to estradiol in the middle-aged anterior hypothalamus partially contribute to the decline of GnRH neuron activation and estradiol target gene expression changes that occur in females along with reproductive aging.
Title: Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats.
This study showed an anti-silicotic effect of db-cAMP that was mediated via PKA/p-CREB/CBP signaling. Furthermore, the findings offer novel insight into the potential use of cAMP signaling for therapeutic strategies to treat silicosis.
Title: Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.
Data indicate that combined treatment of insulin and selenium suppresses cardiomyocyte apoptosis by inhibiting p38-mitogen-activated protein kinase/CREB-binding protein (p38MAPK/CBP) pathway.
Title: [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy].
the fast transient expression of Bdnf promoters II and VI after neuronal stimulation is dependent on acetylation of histone H3K27 by CREB-p/CBP.
Title: Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.
EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression.
Title: Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
miR-22 could inhibit apoptosis of cardiomyocytes through one of its targets, CBP.
Title: MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats.
p300 and CBP are probably involved in the maintenance of neuropathic pain on spinal cord level.
Title: Temporal distribution of p300/CBP immunoreactivity in the adult rat spinal dorsal horn following chronic constriction injury (CCI).

Submit: New GeneRIF Correction See all GeneRIFs (54)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137561 (e-PCR)
- UniSTS:219648

Crebbp (e-PCR), detects polymorphism
- UniSTS:516615

AW558298 (e-PCR)
- UniSTS:180850

RH130099 (e-PCR)
- UniSTS:213387

WI-22537 (e-PCR)
- UniSTS:24526

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables MRF binding	IEA Inferred from Electronic Annotation more info
enables MRF binding	ISO Inferred from Sequence Orthology more info
enables MRF binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIIB-class transcription factor binding	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K18 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables p53 binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables peptide lactyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide lactyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide lactyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in behavioral response to cocaine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within germ-line stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell adhesion molecule production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	IEA Inferred from Electronic Annotation more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone lysine acetyltransferase CREBBP

Names: protein-lysine acetyltransferase CREBBP

NP_596872.3

EC 2.3.1.48

XP_038942595.1

EC 2.3.1.48

XP_038942596.1

EC 2.3.1.48

XP_038942597.1

EC 2.3.1.48

XP_038942598.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133381.5 → NP_596872.3 histone lysine acetyltransferase CREBBP

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q6JHU9

UniProtKB/TrEMBL

F1M9G7

Related

ENSRNOP00000007079.3, ENSRNOT00000007079.6

Conserved Domains (11) summary

cd05495
Location:1088 → 1195

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1767 → 1845

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

COG5076
Location:942 → 1194

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1706 → 1746

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

pfam09606
Location:1961 → 2415

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd15802
Location:1207 → 1279

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1281 → 1312

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam02172
Location:586 → 666

KIX; KIX domain

pfam08214
Location:1343 → 1650

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2035 → 2112

Creb_binding; Creb binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

11842307..11968266

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086667.2 → XP_038942595.1 histone lysine acetyltransferase CREBBP isoform X1

UniProtKB/Swiss-Prot

Q6JHU9

Conserved Domains (11) summary

cd05495
Location:1088 → 1195

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

PHA03247
Location:682 → 1098

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:942 → 1194

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1716 → 1756

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1207 → 1289

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1291 → 1322

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1971 → 2425

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02172
Location:586 → 666

KIX; KIX domain

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam08214
Location:1353 → 1660

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2045 → 2123

Creb_binding; Creb binding
XM_039086668.2 → XP_038942596.1 histone lysine acetyltransferase CREBBP isoform X2

UniProtKB/Swiss-Prot

Q6JHU9

Conserved Domains (11) summary

cd05495
Location:1083 → 1190

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

PHA03247
Location:682 → 1093

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:937 → 1189

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1711 → 1751

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1202 → 1284

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1286 → 1317

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1966 → 2420

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02172
Location:586 → 666

KIX; KIX domain

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam08214
Location:1348 → 1655

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2040 → 2118

Creb_binding; Creb binding
XM_039086669.2 → XP_038942597.1 histone lysine acetyltransferase CREBBP isoform X3

UniProtKB/Swiss-Prot

Q6JHU9

Conserved Domains (11) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

PHA03247
Location:644 → 1060

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:904 → 1156

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1678 → 1718

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1251

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1253 → 1284

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1933 → 2387

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02172
Location:548 → 628

KIX; KIX domain

pfam02135
Location:1745 → 1813

zf-TAZ; TAZ zinc finger

pfam08214
Location:1315 → 1622

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2007 → 2085

Creb_binding; Creb binding
XM_039086670.2 → XP_038942598.1 histone lysine acetyltransferase CREBBP isoform X4

UniProtKB/Swiss-Prot

Q6JHU9

UniProtKB/TrEMBL

A0A8I5ZRH6

Related

ENSRNOP00000080986.1

Conserved Domains (11) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

PHA03247
Location:644 → 1060

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:904 → 1156

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1668 → 1708

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1241

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1243 → 1274

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1923 → 2377

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02172
Location:548 → 628

KIX; KIX domain

pfam02135
Location:1735 → 1803

zf-TAZ; TAZ zinc finger

pfam08214
Location:1305 → 1612

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1997 → 2075

Creb_binding; Creb binding