U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FAM174A family with sequence similarity 174 member A [ Homo sapiens (human) ]

    Gene ID: 345757, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FAM174Aprovided by HGNC
    Official Full Name
    family with sequence similarity 174 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:24943
    See related
    Ensembl:ENSG00000174132 AllianceGenome:HGNC:24943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS5ATP6; TMEM157; UNQ1912; HGS_RE408
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 14.8), adrenal (RPKM 11.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5q21.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (100535374..100586741)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (101043697..101095060)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (99871078..99922445)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379100 Neighboring gene FAM174A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16206 Neighboring gene MPRA-validated peak5372 silencer Neighboring gene MPRA-validated peak5373 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:100058179-100058822 Neighboring gene RN7SK pseudogene 62 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:100112471-100113670 Neighboring gene NANOG hESC enhancer GRCh37_chr5:100121674-100122204 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 Neighboring gene microRNA 548p

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1. Li Z, et al. Biochem Biophys Res Commun, 2016 Jun 17. PMID 27179781
    2. Insights into human Lck SH3 domain binding specificity: different binding modes of artificial and native ligands. Tran T, et al. Biochemistry, 2005 Nov 15. PMID 16274251
    3. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
    4. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NS5ATP6 regulates the intracellular triglyceride level via FGF21, and independently of SIRT1 and SREBP1.
      Title: NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC17345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    membrane protein FAM174A
    Names
    HCV NS5A-transactivated protein 6
    hepatitis C virus NS5A-transactivated protein 6
    hepatitis C virus nonstructural protein 5A trans-activated protein 6
    transmembrane protein 157

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198507.3 → NP_940909.1  membrane protein FAM174A precursor

      See identical proteins and their annotated locations for NP_940909.1

      Status: VALIDATED

      Source sequence(s)
      AY359108, BC027332, BI462478
      Consensus CDS
      CCDS4090.1
      UniProtKB/Swiss-Prot
      A8K0H4, Q8TBP5
      Related
      ENSP00000307954.2, ENST00000312637.5
      Conserved Domains (1) summary
      pfam06679
      Location:35 → 190
      DUF1180; Protein of unknown function (DUF1180)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      100535374..100586741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714600.2 → XP_006714663.1  membrane protein FAM174A isoform X1

      Conserved Domains (1) summary
      pfam06679
      Location:35 → 190
      DUF1180; Protein of unknown function (DUF1180)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      101043697..101095060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352511.1 → XP_054208486.1  membrane protein FAM174A isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBP5.1 GenPept UniProtKB/Swiss-Prot:Q8TBP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous