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    Sfi1 Sfi1 homolog, spindle assembly associated (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 78887, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sfi1provided by MGI
    Official Full Name
    Sfi1 homolog, spindle assembly associated (yeast)provided by MGI
    Primary source
    MGI:MGI:1926137
    See related
    Ensembl:ENSMUSG00000023764 AllianceGenome:MGI:1926137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable phosphatase binding activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; metanephros; perioptic mesenchyme; respiratory system; and skeleton. Orthologous to human SFI1 (SFI1 centrin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 8.7), ovary adult (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 2.19 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3081850..3153344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3131850..3203347, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28338 Neighboring gene STARR-positive B cell enhancer mm9_chr11:3020927-3021228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3023824-3024011 Neighboring gene phosphatidylserine decarboxylase, pseudogene 1 Neighboring gene predicted gene, 33862 Neighboring gene elongation factor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions. Pezer Ž, et al. Genome Res, 2015 Aug. PMID 26149421, Free PMC Article
    2. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. Park CS, et al. BMC Genomics, 2013 Aug 8. PMID 23927422, Free PMC Article
    3. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
    4. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study showed major differences in gene copy number in natural populations. CWC22, SFI1, and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.
      Title: Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA0542, mKIAA0542, C330046E03, 2310047I15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein SFI1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363222.1 → NP_001350151.1  protein SFI1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671968, BX572640
      Conserved Domains (1) summary
      pfam08457
      Location:93 → 369
      Sfi1; Sfi1 spindle body protein

    2. NM_001363223.1 → NP_001350152.1  protein SFI1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL671968, BX572640
      Conserved Domains (2) summary
      pfam08457
      Location:93 → 369
      Sfi1; Sfi1 spindle body protein
      cl25732
      Location:669 → 762
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001363224.1 → NP_001350153.1  protein SFI1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL671968, BX572640
      Conserved Domains (2) summary
      pfam08457
      Location:68 → 344
      Sfi1; Sfi1 spindle body protein
      cl25732
      Location:644 → 737
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_030207.3 → NP_084483.2  protein SFI1 homolog isoform 1

      See identical proteins and their annotated locations for NP_084483.2

      Status: VALIDATED

      Source sequence(s)
      AK133558, BY303229, CK639032
      Consensus CDS
      CCDS36094.1
      UniProtKB/Swiss-Prot
      Q3KQN2, Q3UZY0, Q5NC00, Q6ZQ99, Q80ZJ4, Q80ZY0, Q8R0V8, Q9CTY8
      UniProtKB/TrEMBL
      E9QJT8
      Related
      ENSMUSP00000080066.7, ENSMUST00000081318.13
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3081850..3153344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514902.5 → XP_006514965.1  protein SFI1 homolog isoform X7

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    2. XM_006514903.5 → XP_006514966.1  protein SFI1 homolog isoform X8

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    3. XM_006514900.3 → XP_006514963.1  protein SFI1 homolog isoform X5

      See identical proteins and their annotated locations for XP_006514963.1

      UniProtKB/TrEMBL
      E9Q799
      Conserved Domains (1) summary
      pfam08457
      Location:182 → 662
      Sfi1; Sfi1 spindle body protein

    4. XM_030246435.1 → XP_030102295.1  protein SFI1 homolog isoform X17

      Conserved Domains (1) summary
      pfam08457
      Location:32 → 308
      Sfi1; Sfi1 spindle body protein

    5. XM_036157095.1 → XP_036012988.1  protein SFI1 homolog isoform X10

      UniProtKB/TrEMBL
      E9Q799
      Conserved Domains (1) summary
      pfam08457
      Location:95 → 592
      Sfi1; Sfi1 spindle body protein

    6. XM_011243795.2 → XP_011242097.1  protein SFI1 homolog isoform X13

      Conserved Domains (1) summary
      pfam08457
      Location:51 → 405
      Sfi1; Sfi1 spindle body protein

    7. XM_011243792.2 → XP_011242094.1  protein SFI1 homolog isoform X11

      Conserved Domains (2) summary
      pfam08457
      Location:1 → 431
      Sfi1; Sfi1 spindle body protein
      pfam15385
      Location:564 → 713
      SARG; Specifically androgen-regulated gene protein

    8. XM_006514901.3 → XP_006514964.1  protein SFI1 homolog isoform X6

      UniProtKB/TrEMBL
      E9Q799
      Conserved Domains (1) summary
      pfam08457
      Location:166 → 646
      Sfi1; Sfi1 spindle body protein

    9. XM_036157100.1 → XP_036012993.1  protein SFI1 homolog isoform X16

      Conserved Domains (1) summary
      pfam08457
      Location:15 → 369
      Sfi1; Sfi1 spindle body protein

    10. XM_036157098.1 → XP_036012991.1  protein SFI1 homolog isoform X16

      Conserved Domains (1) summary
      pfam08457
      Location:15 → 369
      Sfi1; Sfi1 spindle body protein

    11. XM_036157099.1 → XP_036012992.1  protein SFI1 homolog isoform X16

      Conserved Domains (1) summary
      pfam08457
      Location:15 → 369
      Sfi1; Sfi1 spindle body protein

    12. XM_030246434.1 → XP_030102294.1  protein SFI1 homolog isoform X15

      Conserved Domains (1) summary
      pfam08457
      Location:68 → 344
      Sfi1; Sfi1 spindle body protein

    13. XM_006514908.3 → XP_006514971.1  protein SFI1 homolog isoform X14

      Conserved Domains (1) summary
      pfam08457
      Location:93 → 369
      Sfi1; Sfi1 spindle body protein

    14. XM_030246433.1 → XP_030102293.1  protein SFI1 homolog isoform X12

      Conserved Domains (1) summary
      pfam08457
      Location:76 → 430
      Sfi1; Sfi1 spindle body protein

    15. XM_006514898.3 → XP_006514961.1  protein SFI1 homolog isoform X4

      UniProtKB/TrEMBL
      E9QJT8
      Related
      ENSMUSP00000067261.8, ENSMUST00000066391.14
      Conserved Domains (2) summary
      TIGR02169
      Location:1090 → 1183
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam08457
      Location:244 → 790
      Sfi1; Sfi1 spindle body protein

    16. XM_006514897.3 → XP_006514960.1  protein SFI1 homolog isoform X3

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:211 → 790
      Sfi1; Sfi1 spindle body protein

    17. XM_006514896.3 → XP_006514959.1  protein SFI1 homolog isoform X2

      See identical proteins and their annotated locations for XP_006514959.1

      UniProtKB/Swiss-Prot
      Q3KQN2, Q3UZY0, Q5NC00, Q6ZQ99, Q80ZJ4, Q80ZY0, Q8R0V8, Q9CTY8
      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    18. XM_006514894.3 → XP_006514957.1  protein SFI1 homolog isoform X1

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    19. XM_017314844.1 → XP_017170333.1  protein SFI1 homolog isoform X15

      Conserved Domains (1) summary
      pfam08457
      Location:68 → 344
      Sfi1; Sfi1 spindle body protein

    20. XM_036157101.1 → XP_036012994.1  protein SFI1 homolog isoform X16

      Conserved Domains (1) summary
      pfam08457
      Location:15 → 369
      Sfi1; Sfi1 spindle body protein

    21. XM_036157096.1 → XP_036012989.1  protein SFI1 homolog isoform X12

      Conserved Domains (1) summary
      pfam08457
      Location:76 → 430
      Sfi1; Sfi1 spindle body protein

    22. XM_006514899.3 → XP_006514962.1  protein SFI1 homolog isoform X5

      See identical proteins and their annotated locations for XP_006514962.1

      UniProtKB/TrEMBL
      E9Q799
      Conserved Domains (1) summary
      pfam08457
      Location:182 → 662
      Sfi1; Sfi1 spindle body protein

    23. XM_017314841.2 → XP_017170330.1  protein SFI1 homolog isoform X1

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    24. XM_017314842.3 → XP_017170331.1  protein SFI1 homolog isoform X1

      UniProtKB/TrEMBL
      E9QJT8
      Conserved Domains (1) summary
      pfam08457
      Location:328 → 808
      Sfi1; Sfi1 spindle body protein

    25. XM_036157097.1 → XP_036012990.1  protein SFI1 homolog isoform X13

      Conserved Domains (1) summary
      pfam08457
      Location:51 → 405
      Sfi1; Sfi1 spindle body protein

    26. XM_036157094.1 → XP_036012987.1  protein SFI1 homolog isoform X9

      UniProtKB/TrEMBL
      E9Q799
      Conserved Domains (1) summary
      pfam08457
      Location:112 → 609
      Sfi1; Sfi1 spindle body protein

    27. XM_036157102.1 → XP_036012995.1  protein SFI1 homolog isoform X18

      Conserved Domains (2) summary
      TIGR02169
      Location:608 → 701
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam08457
      Location:32 → 308
      Sfi1; Sfi1 spindle body protein

    RNA

    1. XR_003949531.2 RNA Sequence

    2. XR_004937060.1 RNA Sequence

    3. XR_003949530.2 RNA Sequence

    4. XR_004937059.1 RNA Sequence

    5. XR_001780078.3 RNA Sequence

    6. XR_001780077.3 RNA Sequence

    7. XR_004937058.1 RNA Sequence

    8. XR_380988.5 RNA Sequence

    9. XR_872210.4 RNA Sequence

    10. XR_001780076.3 RNA Sequence

    11. XR_004937061.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZY0.1 GenPept UniProtKB/Swiss-Prot:Q3UZY0

    Gene LinkOut

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