Wdr6 WD repeat domain 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr6provided by MGI
Official Full Name: WD repeat domain 6provided by MGI
Primary source: MGI:MGI:1930140
See related: Ensembl:ENSMUSG00000066357 AllianceGenome:MGI:1930140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable insulin receptor substrate binding activity. Predicted to be involved in several processes, including negative regulation of autophagy; negative regulation of cell population proliferation; and tRNA methylation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Is expressed in central nervous system; nervous system; neural retinal epithelium; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in whole brain E14.5 (RPKM 110.8), CNS E14 (RPKM 87.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.51 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108449510..108455862, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108572311..108578713, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI853847 (e-PCR)
- UniSTS:164420

RH126251 (e-PCR)
- UniSTS:162959

BB128974 (e-PCR)
- UniSTS:185807

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in wobble position ribose methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA (34-2'-O)-methyltransferase regulator WDR6

Names: WD repeat-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031392.4 → NP_113569.1 tRNA (34-2'-O)-methyltransferase regulator WDR6

See identical proteins and their annotated locations for NP_113569.1

Status: VALIDATED

Source sequence(s)

CT010508, CT571271

Consensus CDS

CCDS23532.2

UniProtKB/Swiss-Prot

Q99ME2

UniProtKB/TrEMBL

Q3TEZ2

Related

ENSMUSP00000070927.6, ENSMUST00000068700.7

Conserved Domains (3) summary

COG2319
Location:79 → 388

WD40; WD40 repeat [General function prediction only]

sd00039
Location:212 → 252

7WD40; WD40 repeat [structural motif]

cl02567
Location:110 → 325

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...