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    F10 coagulation factor X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29243, updated on 5-Mar-2024

    Summary

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    Official Symbol
    F10provided by RGD
    Official Full Name
    coagulation factor Xprovided by RGD
    Primary source
    RGD:61850
    See related
    Ensembl:ENSRNOG00000033444 AllianceGenome:RGD:61850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipid binding activity and serine-type endopeptidase activity. Involved in blood coagulation. Located in endoplasmic reticulum and membrane. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in breast cancer and factor X deficiency. Orthologous to human F10 (coagulation factor X). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 1929.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See F10 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83170973..83190280, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76468834..76488141, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81803169..81822476, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482531 Neighboring gene PCI domain containing 2 Neighboring gene small ribosomal subunit protein eS19-like Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene coagulation factor VII Neighboring gene MCF.2 cell line derived transforming sequence-like Neighboring gene uncharacterized LOC134482421

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence for competition between vitamin K-dependent clotting factors for intracellular processing by the vitamin K-dependent gamma-carboxylase. Stanton C, et al. Thromb Res, 1995 Oct 1. PMID 8578539
    2. Intracellular proteolytic processing of the two-chain vitamin K-dependent coagulation factor X. Wallin R, et al. Thromb Res, 1994 Mar 15. PMID 8073392
    3. The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats. Morishima Y, et al. Thromb Res, 2013 Jan. PMID 22999414
    4. Coagulation and fibrinolysis abnormalities in familial amyloid polyneuropathy. Takahashi R, et al. Amyloid, 2012 Sep. PMID 22624582
    5. Severe factor X deficiency in three unrelated Palestinian patients is caused by homozygosity for the mutation c302delG-correlation with thrombin generation and thromboelastometry. Livnat T, et al. Blood Coagul Fibrinolysis, 2011 Dec. PMID 22008904

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Factor Xa inhibitor edoxaban at or higher doses than needed for an antithrombotic effect sustained the circulating Gla-osteocalcin level.
      Title: The effects of warfarin and edoxaban, an oral direct factor Xa inhibitor, on gammacarboxylated (Gla-osteocalcin) and undercarboxylated osteocalcin (uc-osteocalcin) in rats.
    2. Report differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding.
      Title: Differential effects of TAK-442, a novel orally active direct factor Xa inhibitor, and ximelagatran, a thrombin inhibitor, on factor V-mediated feedback on coagulation cascade and bleeding.
    3. The changes in levels of blood coagulation factor X in folic acid deficient rats are reversed by treatment with folic acid.
      Title: Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II.
    4. Factor Xa has a role in inducing mitogenesis of vascular smooth muscle cells by autocrine production of epiregulin
      Title: Factor Xa induces mitogenesis of vascular smooth muscle cells via autocrine production of epiregulin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC108722

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coagulation factor X
    Names
    coagulation factor 10
    stuart factor
    NP_058839.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017143.2 → NP_058839.1  coagulation factor X precursor

      See identical proteins and their annotated locations for NP_058839.1

      Status: VALIDATED

      Source sequence(s)
      BC088151
      UniProtKB/Swiss-Prot
      Q63207
      UniProtKB/TrEMBL
      A0A0H2UHR6, A6IWK2
      Related
      ENSRNOP00000026677.5, ENSRNOT00000026677.7
      Conserved Domains (4) summary
      smart00069
      Location:23 → 84
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:86 → 122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:232 → 462
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:129 → 164
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      83170973..83190280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63207.1 GenPept UniProtKB/Swiss-Prot:Q63207

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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