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    Ablim2 actin binding LIM protein family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360958, updated on 2-May-2024

    Summary

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    Official Symbol
    Ablim2provided by RGD
    Official Full Name
    actin binding LIM protein family, member 2provided by RGD
    Primary source
    RGD:1303094
    See related
    Ensembl:ENSRNOG00000007882 AllianceGenome:RGD:1303094
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in myofibril. Predicted to be active in actin cytoskeleton. Orthologous to human ABLIM2 (actin binding LIM protein family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 135.8), Brain (RPKM 110.6) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79090046..79214986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74865409..74990334, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80044217..80169491, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 Neighboring gene uncharacterized LOC134481856 Neighboring gene uncharacterized LOC134481855 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene HtrA serine peptidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic organisation and tissue specific expression of ABLIM2 gene in human, mouse and rat. Klimov E, et al. Biochim Biophys Acta, 2005 Jul 25. PMID 16005990
    2. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. Barrientos T, et al. J Biol Chem, 2007 Mar 16. PMID 17194709
    3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding LIM protein 2
    Names
    abLIM-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001514.2 → NP_001001514.1  actin-binding LIM protein 2 isoform b

      See identical proteins and their annotated locations for NP_001001514.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame two-exon segment in the 3' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AJ703893
      UniProtKB/TrEMBL
      A0A140TAH7
      Related
      ENSRNOP00000010482.8, ENSRNOT00000010482.8
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:539 → 573
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 537
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001177695.1 → NP_001171166.1  actin-binding LIM protein 2 isoform a

      See identical proteins and their annotated locations for NP_001171166.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AJ703892
      UniProtKB/Swiss-Prot
      Q6KC50, Q6KC51
      UniProtKB/TrEMBL
      A0A140TAH7
      Related
      ENSRNOP00000055116.5, ENSRNOT00000058315.6
      Conserved Domains (6) summary
      cd09327
      Location:24 → 75
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:80 → 135
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:153 → 204
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:212 → 267
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam02209
      Location:578 → 612
      VHP; Villin headpiece domain
      pfam16182
      Location:277 → 576
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79090046..79214986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273369.1 → XP_063129439.1  actin-binding LIM protein 2 isoform X7

    2. XM_063273367.1 → XP_063129437.1  actin-binding LIM protein 2 isoform X5

    3. XM_063273363.1 → XP_063129433.1  actin-binding LIM protein 2 isoform X2

    4. XM_063273380.1 → XP_063129450.1  actin-binding LIM protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A0G2JXC7

    5. XM_063273368.1 → XP_063129438.1  actin-binding LIM protein 2 isoform X6

    6. XM_063273371.1 → XP_063129441.1  actin-binding LIM protein 2 isoform X9

    7. XM_063273377.1 → XP_063129447.1  actin-binding LIM protein 2 isoform X15

    8. XM_063273378.1 → XP_063129448.1  actin-binding LIM protein 2 isoform X16

    9. XM_063273384.1 → XP_063129454.1  actin-binding LIM protein 2 isoform X21

    10. XM_063273385.1 → XP_063129455.1  actin-binding LIM protein 2 isoform X22

    11. XM_063273374.1 → XP_063129444.1  actin-binding LIM protein 2 isoform X12

    12. XM_063273362.1 → XP_063129432.1  actin-binding LIM protein 2 isoform X1

    13. XM_063273364.1 → XP_063129434.1  actin-binding LIM protein 2 isoform X3

    14. XM_063273381.1 → XP_063129451.1  actin-binding LIM protein 2 isoform X19

    15. XM_063273379.1 → XP_063129449.1  actin-binding LIM protein 2 isoform X17

    16. XM_063273366.1 → XP_063129436.1  actin-binding LIM protein 2 isoform X4

    17. XM_063273383.1 → XP_063129453.1  actin-binding LIM protein 2 isoform X20

    18. XM_063273372.1 → XP_063129442.1  actin-binding LIM protein 2 isoform X10

    19. XM_063273376.1 → XP_063129446.1  actin-binding LIM protein 2 isoform X14

    20. XM_063273373.1 → XP_063129443.1  actin-binding LIM protein 2 isoform X11

    21. XM_063273375.1 → XP_063129445.1  actin-binding LIM protein 2 isoform X13

    22. XM_063273370.1 → XP_063129440.1  actin-binding LIM protein 2 isoform X8

    23. XM_063273387.1 → XP_063129457.1  actin-binding LIM protein 2 isoform X24

    24. XM_063273386.1 → XP_063129456.1  actin-binding LIM protein 2 isoform X23

    RNA

    1. XR_010057396.1 RNA Sequence

    2. XR_010057389.1 RNA Sequence

    3. XR_010057397.1 RNA Sequence

    4. XR_010057390.1 RNA Sequence

    5. XR_010057387.1 RNA Sequence

    6. XR_010057388.1 RNA Sequence

    7. XR_010057395.1 RNA Sequence

    8. XR_010057393.1 RNA Sequence

    9. XR_010057392.1 RNA Sequence

    10. XR_010057394.1 RNA Sequence

    11. XR_010057391.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6KC51.1 GenPept UniProtKB/Swiss-Prot:Q6KC51

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