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    MYO9A myosin IXA [ Homo sapiens (human) ]

    Gene ID: 4649, updated on 6-Jun-2024

    Summary

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    Official Symbol
    MYO9Aprovided by HGNC
    Official Full Name
    myosin IXAprovided by HGNC
    Primary source
    HGNC:HGNC:7608
    See related
    Ensembl:ENSG00000066933 MIM:604875; AllianceGenome:HGNC:7608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMS24
    Summary
    This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with Bardet-Biedl Syndrome. [provided by RefSeq, Dec 2011]
    Expression
    Broad expression in testis (RPKM 12.9), thyroid (RPKM 5.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYO9A in Genome Data Viewer
    Location:
    15q23
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (71822291..72118600, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (69641241..69935336, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (72114632..72410491, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene thrombospondin type 1 domain containing 4 Neighboring gene THSD4 antisense RNA 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:72053567-72054766 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9705 Neighboring gene Sharpr-MPRA regulatory region 1602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9709 Neighboring gene RNA, 5S ribosomal pseudogene 399 Neighboring gene nuclear receptor subfamily 2 group E member 3 Neighboring gene uncharacterized LOC107984713 Neighboring gene uncharacterized LOC107984714 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:72323133-72323348 Neighboring gene eukaryotic translation initiation factor 5A2 pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:72394409-72394919 Neighboring gene RNA, U2 small nuclear 65, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9712 Neighboring gene uncharacterized LOC124903522 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9713 Neighboring gene Sharpr-MPRA regulatory region 4122 Neighboring gene ribosomal protein L21 pseudogene 115 Neighboring gene SUMO peptidase family member, NEDD8 specific Neighboring gene GRAM domain containing 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Self-organization of actin networks by a monomeric myosin. Saczko-Brack D, et al. Proc Natl Acad Sci U S A, 2016 Dec 27. PMID 27956608, Free PMC Article
    2. Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Omelchenko T, et al. Curr Biol, 2012 Feb 21. PMID 22305756, Free PMC Article
    3. Class IX Myosins: Motorized RhoGAP Signaling Molecules. Hanley PJ, et al. Adv Exp Med Biol, 2020. PMID 32451867
    4. The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23. Gorman SW, et al. Genomics, 1999 Jul 15. PMID 10409426
    5. Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis. Li Q, et al. Kidney Int, 2021 May. PMID 33412162, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
      Title: Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
    2. Class IX Myosins: Motorized RhoGAP Signaling Molecules.
      Title: Class IX Myosins: Motorized RhoGAP Signaling Molecules.
    3. analysis of actin network self-organization by a monomeric myosin IXa
      Title: Self-organization of actin networks by a monomeric myosin.
    4. MYO9A deficiency may affect the presynaptic motor axon, manifesting in congenital myasthenic syndrome.
      Title: Identification of mutations in the MYO9A gene in patients with congenital myasthenic syndrome.
    5. Vaccinia virus F11 promotes viral spread by binding to host myosin-9A and inhibit RhoA signaling.
      Title: Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling.
    6. Depletion of myosin-IXA in collectively migrating cells led to altered organization of the actin cytoskeleton and tension-dependent disruption of cell-cell adhesions, followed by an inability to form new adhesions resulting in cell scattering.
      Title: Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Congenital myasthenic syndrome
    MedGen: C0751882 GeneReviews: Congenital Myasthenic Syndromes Overview
    		Compare labs
    Myasthenic syndrome, congenital, 24, presynaptic
    MedGen: C4748684 OMIM: 618198 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11061, FLJ13244, MGC71859

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonal growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of unconventional myosin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    unconventional myosin-IXa
    Names
    myosin-IXa
    unconventional myosin-9a

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006901.4 → NP_008832.2  unconventional myosin-IXa

      See identical proteins and their annotated locations for NP_008832.2

      Status: REVIEWED

      Source sequence(s)
      AC020779, AC022872, AC104938, AF117888, BC060886, BC140869, BC150294, DB100556
      Consensus CDS
      CCDS10239.1
      UniProtKB/Swiss-Prot
      B0I1T5, B2RTY4, C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2
      UniProtKB/TrEMBL
      A0A2X0SFG5
      Related
      ENSP00000348349.5, ENST00000356056.10
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2000 → 2048
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2061 → 2246
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      71822291..72118600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432576.1 → XP_047288532.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    2. XM_047432553.1 → XP_047288509.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    3. XM_047432585.1 → XP_047288541.1  unconventional myosin-IXa isoform X20

      UniProtKB/TrEMBL
      A0A2X0SFG5

    4. XM_047432571.1 → XP_047288527.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    5. XM_047432556.1 → XP_047288512.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    6. XM_047432578.1 → XP_047288534.1  unconventional myosin-IXa isoform X16

      UniProtKB/Swiss-Prot
      B0I1T5, B2RTY4, C9IYB3, C9JA86, Q14787, Q3YLD7, Q3YLD8, Q6P986, Q9H8T5, Q9NTG2, Q9NUY2, Q9UEP3, Q9UNJ2
      UniProtKB/TrEMBL
      A0A2X0SFG5

    7. XM_011521615.4 → XP_011519917.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_011519917.1

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2072 → 2120
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2133 → 2318
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    8. XM_047432573.1 → XP_047288529.1  unconventional myosin-IXa isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFG5

    9. XM_047432569.1 → XP_047288525.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    10. XM_047432580.1 → XP_047288536.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    11. XM_047432559.1 → XP_047288515.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    12. XM_047432554.1 → XP_047288510.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    13. XM_047432551.1 → XP_047288507.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    14. XM_047432584.1 → XP_047288540.1  unconventional myosin-IXa isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFG5

    15. XM_047432565.1 → XP_047288521.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    16. XM_047432561.1 → XP_047288517.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5

    17. XM_047432575.1 → XP_047288531.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    18. XM_047432549.1 → XP_047288505.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5

    19. XM_047432547.1 → XP_047288503.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5

    20. XM_011521616.4 → XP_011519918.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_011519918.1

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2072 → 2120
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2133 → 2318
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    21. XM_047432577.1 → XP_047288533.1  unconventional myosin-IXa isoform X15

      UniProtKB/TrEMBL
      A0A2X0SFG5

    22. XM_047432572.1 → XP_047288528.1  unconventional myosin-IXa isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFG5

    23. XM_047432568.1 → XP_047288524.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    24. XM_047432581.1 → XP_047288537.1  unconventional myosin-IXa isoform X18

      UniProtKB/TrEMBL
      A0A2X0SFG5

    25. XM_017022230.3 → XP_016877719.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    26. XM_047432558.1 → XP_047288514.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    27. XM_011521620.4 → XP_011519922.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 995
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2052 → 2100
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2113 → 2298
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 985
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    28. XM_047432557.1 → XP_047288513.1  unconventional myosin-IXa isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFG5

    29. XM_011521619.4 → XP_011519921.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 995
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2053 → 2101
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2114 → 2299
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 985
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    30. XM_047432583.1 → XP_047288539.1  unconventional myosin-IXa isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFG5

    31. XM_047432567.1 → XP_047288523.1  unconventional myosin-IXa isoform X11

      UniProtKB/TrEMBL
      A0A2X0SFG5

    32. XM_047432564.1 → XP_047288520.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    33. XM_011521621.4 → XP_011519923.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 974
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2032 → 2080
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2093 → 2278
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 964
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    34. XM_011521622.4 → XP_011519924.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2000 → 2048
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2061 → 2246
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    35. XM_006720539.4 → XP_006720602.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2071 → 2119
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2132 → 2317
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    36. XM_011521617.4 → XP_011519919.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2071 → 2119
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2132 → 2317
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    37. XM_011521618.4 → XP_011519920.1  unconventional myosin-IXa isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2072 → 2120
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2133 → 2318
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    38. XM_011521613.4 → XP_011519915.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_011519915.1

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2072 → 2120
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2133 → 2318
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    39. XM_047432570.1 → XP_047288526.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    40. XM_047432579.1 → XP_047288535.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    41. XM_047432560.1 → XP_047288516.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    42. XM_047432555.1 → XP_047288511.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    43. XM_047432552.1 → XP_047288508.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    44. XM_047432566.1 → XP_047288522.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    45. XM_047432562.1 → XP_047288518.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5

    46. XM_017022229.2 → XP_016877718.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2000 → 2048
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2061 → 2246
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    47. XM_047432550.1 → XP_047288506.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5

    48. XM_047432548.1 → XP_047288504.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5

    49. XM_011521614.4 → XP_011519916.1  unconventional myosin-IXa isoform X1

      See identical proteins and their annotated locations for XP_011519916.1

      UniProtKB/TrEMBL
      A0A2X0SFG5
      Conserved Domains (5) summary
      smart00242
      Location:143 → 1014
      MYSc; Myosin. Large ATPases
      cd00029
      Location:2072 → 2120
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd04377
      Location:2133 → 2318
      RhoGAP_myosin_IX; RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a ...
      cd01385
      Location:160 → 1004
      MYSc_Myo9; class IX myosin, motor domain
      cl00155
      Location:6 → 110
      UBQ; Ubiquitin-like proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      69641241..69935336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378013.1 → XP_054233988.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    2. XM_054377988.1 → XP_054233963.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    3. XM_054378022.1 → XP_054233997.1  unconventional myosin-IXa isoform X20

      UniProtKB/TrEMBL
      A0A2X0SFG5

    4. XM_054378007.1 → XP_054233982.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    5. XM_054377991.1 → XP_054233966.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    6. XM_054378015.1 → XP_054233990.1  unconventional myosin-IXa isoform X16

      UniProtKB/TrEMBL
      A0A2X0SFG5

    7. XM_054377977.1 → XP_054233952.1  unconventional myosin-IXa isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFG5

    8. XM_054378009.1 → XP_054233984.1  unconventional myosin-IXa isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFG5

    9. XM_054378005.1 → XP_054233980.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    10. XM_054378018.1 → XP_054233993.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    11. XM_054377995.1 → XP_054233970.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    12. XM_054377989.1 → XP_054233964.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    13. XM_054377986.1 → XP_054233961.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    14. XM_054378021.1 → XP_054233996.1  unconventional myosin-IXa isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFG5

    15. XM_054378000.1 → XP_054233975.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    16. XM_054377998.1 → XP_054233973.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5

    17. XM_054378011.1 → XP_054233986.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    18. XM_054377983.1 → XP_054233958.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5

    19. XM_054377979.1 → XP_054233954.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5

    20. XM_054377975.1 → XP_054233950.1  unconventional myosin-IXa isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFG5

    21. XM_054378014.1 → XP_054233989.1  unconventional myosin-IXa isoform X15

      UniProtKB/TrEMBL
      A0A2X0SFG5

    22. XM_054378008.1 → XP_054233983.1  unconventional myosin-IXa isoform X13

      UniProtKB/TrEMBL
      A0A2X0SFG5

    23. XM_054378004.1 → XP_054233979.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    24. XM_054378019.1 → XP_054233994.1  unconventional myosin-IXa isoform X18

      UniProtKB/TrEMBL
      A0A2X0SFG5

    25. XM_054378016.1 → XP_054233991.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    26. XM_054377994.1 → XP_054233969.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    27. XM_054377992.1 → XP_054233967.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    28. XM_054377993.1 → XP_054233968.1  unconventional myosin-IXa isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFG5

    29. XM_054377985.1 → XP_054233960.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    30. XM_054378020.1 → XP_054233995.1  unconventional myosin-IXa isoform X19

      UniProtKB/TrEMBL
      A0A2X0SFG5

    31. XM_054378003.1 → XP_054233978.1  unconventional myosin-IXa isoform X11

      UniProtKB/TrEMBL
      A0A2X0SFG5

    32. XM_054378002.1 → XP_054233977.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    33. XM_054377997.1 → XP_054233972.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5

    34. XM_054378010.1 → XP_054233985.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    35. XM_054377982.1 → XP_054233957.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5

    36. XM_054377978.1 → XP_054233953.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5

    37. XM_054377981.1 → XP_054233956.1  unconventional myosin-IXa isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFG5

    38. XM_054377974.1 → XP_054233949.1  unconventional myosin-IXa isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFG5

    39. XM_054378006.1 → XP_054233981.1  unconventional myosin-IXa isoform X12

      UniProtKB/TrEMBL
      A0A2X0SFG5

    40. XM_054378017.1 → XP_054233992.1  unconventional myosin-IXa isoform X17

      UniProtKB/TrEMBL
      A0A2X0SFG5

    41. XM_054377996.1 → XP_054233971.1  unconventional myosin-IXa isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFG5

    42. XM_054377990.1 → XP_054233965.1  unconventional myosin-IXa isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFG5

    43. XM_054377987.1 → XP_054233962.1  unconventional myosin-IXa isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFG5

    44. XM_054378001.1 → XP_054233976.1  unconventional myosin-IXa isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFG5

    45. XM_054377999.1 → XP_054233974.1  unconventional myosin-IXa isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFG5

    46. XM_054378012.1 → XP_054233987.1  unconventional myosin-IXa isoform X14

      UniProtKB/TrEMBL
      A0A2X0SFG5

    47. XM_054377984.1 → XP_054233959.1  unconventional myosin-IXa isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFG5

    48. XM_054377980.1 → XP_054233955.1  unconventional myosin-IXa isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFG5

    49. XM_054377976.1 → XP_054233951.1  unconventional myosin-IXa isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFG5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RTY4.2 GenPept UniProtKB/Swiss-Prot:B2RTY4

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