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    Naa16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit [ Mus musculus (house mouse) ]

    Gene ID: 66897, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Naa16provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 16, NatA auxiliary subunitprovided by MGI
    Primary source
    MGI:MGI:1914147
    See related
    Ensembl:ENSMUSG00000022020 AllianceGenome:MGI:1914147
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Narg1l; 1300019C06Rik
    Summary
    Predicted to enable ribosome binding activity. Predicted to contribute to peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation; negative regulation of apoptotic process; and protein stabilization. Predicted to be located in cytosol. Predicted to be part of NatA complex. Predicted to be active in cytoplasm. Orthologous to human NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.8), liver E14 (RPKM 3.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D3; 14 42.61 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79571947..79628228, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79334507..79390788, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79643421-79643608 Neighboring gene STARR-seq mESC enhancer starr_37253 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79667780-79667981 Neighboring gene STARR-seq mESC enhancer starr_37256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79680321-79680522 Neighboring gene STARR-seq mESC enhancer starr_37257 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79691968-79692228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79693274-79693461 Neighboring gene regulator of cell cycle Neighboring gene STARR-positive B cell enhancer ABC_E11576 Neighboring gene STARR-positive B cell enhancer ABC_E4121 Neighboring gene STARR-positive B cell enhancer ABC_E7342 Neighboring gene STARR-positive B cell enhancer ABC_E7343 Neighboring gene STARR-positive B cell enhancer ABC_E4122 Neighboring gene mitochondrial translational release factor 1 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum. Newbury AJ, et al. Front Genet, 2012. PMID 22666227, Free PMC Article
    2. An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. Sugiura N, et al. J Biol Chem, 2003 Oct 10. PMID 12888564
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 16, NatA auxiliary subunit
    Names
    NARG1-like protein
    NMDA receptor-regulated 1-like protein
    Nalpha acetyltransferase 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025832.2 → NP_080108.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit

      See identical proteins and their annotated locations for NP_080108.1

      Status: PROVISIONAL

      Source sequence(s)
      BC052445
      Consensus CDS
      CCDS27296.1
      UniProtKB/Swiss-Prot
      Q3U7V2, Q9DBB4
      Related
      ENSMUSP00000022597.8, ENSMUST00000022597.15
      Conserved Domains (4) summary
      sd00006
      Location:82 → 108
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:87 → 113
      TPR_1; Tetratricopeptide repeat
      pfam12569
      Location:187 → 698
      NARP1; NMDA receptor-regulated protein 1
      pfam13414
      Location:82 → 145
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      79571947..79628228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519399.2 → XP_006519462.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1

      Conserved Domains (2) summary
      sd00006
      Location:246 → 270
      TPR; TPR repeat [structural motif]
      pfam12569
      Location:55 → 566
      NARP1; NMDA receptor-regulated protein 1

    2. XM_030247958.1 → XP_030103818.1  N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2

      Conserved Domains (1) summary
      pfam12569
      Location:1 → 286
      NARP1; NMDA receptor-regulated protein 1

    RNA

    1. XR_004938440.1 RNA Sequence

    2. XR_001781144.2 RNA Sequence

    3. XR_001781145.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBB4.1 GenPept UniProtKB/Swiss-Prot:Q9DBB4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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