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    ZNF730 zinc finger protein 730 [ Homo sapiens (human) ]

    Gene ID: 100129543, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF730provided by HGNC
    Official Full Name
    zinc finger protein 730provided by HGNC
    Primary source
    HGNC:HGNC:32470
    See related
    Ensembl:ENSG00000183850 AllianceGenome:HGNC:32470
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
    NEW
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    Genomic context

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    See ZNF730 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23075211..23147221)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23210338..23282034)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23299827..23330023)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1859 Neighboring gene long intergenic non-protein coding RNA 1858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23257625-23258372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:23260515-23261088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23276545-23277044 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 37 Neighboring gene sorting nexin 6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23343199-23343774 Neighboring gene MPRA-validated peak3415 silencer Neighboring gene zinc finger protein 724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14391 Neighboring gene BCL2 interacting protein 3 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10460 Neighboring gene importin 5 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative zinc finger protein 730

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277403.2 → NP_001264332.1  putative zinc finger protein 730

      See identical proteins and their annotated locations for NP_001264332.1

      Status: VALIDATED

      Source sequence(s)
      AC092329, AK131472
      Consensus CDS
      CCDS59371.1
      UniProtKB/Swiss-Prot
      Q6ZMV8
      Related
      ENSP00000472959.1, ENST00000597761.7
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:143 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:398 → 418
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      23075211..23147221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437995.1 → XP_047293951.1  putative zinc finger protein 730 isoform X4

    2. XM_047437996.1 → XP_047293952.1  putative zinc finger protein 730 isoform X4

    3. XM_047437997.1 → XP_047293953.1  putative zinc finger protein 730 isoform X4

    4. XM_047437999.1 → XP_047293955.1  putative zinc finger protein 730 isoform X4

    5. XM_047437998.1 → XP_047293954.1  putative zinc finger protein 730 isoform X4

    6. XM_017026115.3 → XP_016881604.1  putative zinc finger protein 730 isoform X2

    7. XM_047438000.1 → XP_047293956.1  putative zinc finger protein 730 isoform X4

    8. XM_047437994.1 → XP_047293950.1  putative zinc finger protein 730 isoform X4

    9. XM_047438004.1 → XP_047293960.1  putative zinc finger protein 730 isoform X4

    10. XM_047438001.1 → XP_047293957.1  putative zinc finger protein 730 isoform X4

    11. XM_017026114.2 → XP_016881603.1  putative zinc finger protein 730 isoform X1

    12. XM_047438005.1 → XP_047293961.1  putative zinc finger protein 730 isoform X6

    13. XM_047437993.1 → XP_047293949.1  putative zinc finger protein 730 isoform X3

    14. XM_047438002.1 → XP_047293958.1  putative zinc finger protein 730 isoform X5

    15. XM_047438003.1 → XP_047293959.1  putative zinc finger protein 730 isoform X5

    RNA

    1. XR_001753564.2 RNA Sequence

    2. XR_001753566.3 RNA Sequence

    3. XR_001753565.2 RNA Sequence

    4. XR_001753568.2 RNA Sequence

    5. XR_007066501.1 RNA Sequence

    6. XR_001753567.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      23210338..23282034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319432.1 → XP_054175407.1  putative zinc finger protein 730 isoform X2

    2. XM_054319434.1 → XP_054175409.1  putative zinc finger protein 730 isoform X7

    3. XM_054319438.1 → XP_054175413.1  putative zinc finger protein 730 isoform X7

    4. XM_054319441.1 → XP_054175416.1  putative zinc finger protein 730 isoform X4

    5. XM_054319436.1 → XP_054175411.1  putative zinc finger protein 730 isoform X7

    6. XM_054319442.1 → XP_054175417.1  putative zinc finger protein 730 isoform X4

    7. XM_054319437.1 → XP_054175412.1  putative zinc finger protein 730 isoform X7

    8. XM_054319440.1 → XP_054175415.1  putative zinc finger protein 730 isoform X7

    9. XM_054319439.1 → XP_054175414.1  putative zinc finger protein 730 isoform X7

    10. XM_054319443.1 → XP_054175418.1  putative zinc finger protein 730 isoform X4

    11. XM_054319435.1 → XP_054175410.1  putative zinc finger protein 730 isoform X7

    12. XM_054319447.1 → XP_054175422.1  putative zinc finger protein 730 isoform X4

    13. XM_054319444.1 → XP_054175419.1  putative zinc finger protein 730 isoform X4

    14. XM_054319431.1 → XP_054175406.1  putative zinc finger protein 730 isoform X1

    15. XM_054319448.1 → XP_054175423.1  putative zinc finger protein 730 isoform X6

    16. XM_054319433.1 → XP_054175408.1  putative zinc finger protein 730 isoform X3

    17. XM_054319445.1 → XP_054175420.1  putative zinc finger protein 730 isoform X5

    18. XM_054319446.1 → XP_054175421.1  putative zinc finger protein 730 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZMV8.1 GenPept UniProtKB/Swiss-Prot:Q6ZMV8

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