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    CNOT3 CCR4-NOT transcription complex subunit 3 [ Homo sapiens (human) ]

    Gene ID: 4849, updated on 5-May-2024

    Summary

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    Official Symbol
    CNOT3provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:7879
    See related
    Ensembl:ENSG00000088038 MIM:604910; AllianceGenome:HGNC:7879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOT3; LENG2; NOT3H; IDDSADF
    Summary
    Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 13.9), spleen (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Try the new Transcript table

    Genomic context

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    Location:
    19q13.42
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (54137762..54155681)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (57217961..57235947)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54641478..54659419)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54617323-54618196 Neighboring gene TCF3 fusion partner Neighboring gene PRPF31 antisense RNA 1 Neighboring gene pre-mRNA processing factor 31 Neighboring gene uncharacterized LOC102724273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54662792-54663461 Neighboring gene leukocyte receptor cluster member 1 Neighboring gene transmembrane channel like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54676977-54677793 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54677794-54678609 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54683683-54684198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684199-54684714 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:54684715-54685229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:54687509-54688008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:54692762-54693444 Neighboring gene tRNA splicing endonuclease subunit 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients. Zhao P, et al. Neurogenetics, 2023 Apr. PMID 36802310
    2. Inherited cases of CNOT3-associated intellectual developmental disorder with speech delay, autism, and dysmorphic facies. Meyer R, et al. Clin Genet, 2020 Oct. PMID 32720325
    3. De novo variants in CNOT3 cause a variable neurodevelopmental disorder. Martin R, et al. Eur J Hum Genet, 2019 Nov. PMID 31201375, Free PMC Article
    4. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development. Shirai YT, et al. Oncogene, 2019 Apr. PMID 30531840
    5. Cnot3 enhances human embryonic cardiomyocyte proliferation by promoting cell cycle inhibitor mRNA degradation. Zhou B, et al. Sci Rep, 2017 May 4. PMID 28473716, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
      Title: Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis.
    2. CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
      Title: CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infection.
    3. Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients.
      Title: Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients.
    4. CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
      Title: CNOT3 interacts with the Aurora B and MAPK/ERK kinases to promote survival of differentiating mesendodermal progenitor cells.
    5. Determinants of Disease Penetrance in PRPF31-Associated Retinopathy.
      Title: Determinants of Disease Penetrance in PRPF31-Associated Retinopathy.
    6. A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.
      Title: A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.
    7. Inherited cases of CNOT3-associated intellectual developmental disorder with speech delay, autism, and dysmorphic facies.
      Title: Inherited cases of CNOT3-associated intellectual developmental disorder with speech delay, autism, and dysmorphic facies.
    8. The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
      Title: The pleiotropy associated with de novo variants in CHD4, CNOT3, and SETD5 extends to moyamoya angiopathy.
    9. De novo variants in CNOT3 cause a variable neurodevelopmental disorder.
      Title: De novo variants in CNOT3 cause a variable neurodevelopmental disorder.
    10. CCR4-NOT transcription complex subunit 3 (CNOT3) is up-regulated in lung cancer tissues and is associated with poor prognosis of the patients. Knocking down CNOT3 expression sensitizes cisplatin-resistant A549 (A549/DDP) cells to cisplatin-induced apoptosis. CNOT3 depletion up-regulates the expression level of RIPK3 and the enhanced apoptosis is mediated by the elevated RIPK3 to further trigger Caspase 8 activation.
      Title: CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual developmental disorder with speech delay, autism, and dysmorphic facies
    MedGen: C5231456 OMIM: 618672 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2018-06-27)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2018-06-27)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0691

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trophectodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 3
    Names
    CCR4-associated factor 3
    NOT3 (negative regulator of transcription 3, yeast) homolog
    leukocyte receptor cluster member 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014516.4 → NP_055331.1  CCR4-NOT transcription complex subunit 3

      See identical proteins and their annotated locations for NP_055331.1

      Status: VALIDATED

      Source sequence(s)
      AC245052
      Consensus CDS
      CCDS12880.1
      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76
      UniProtKB/TrEMBL
      B7Z6J7
      Related
      ENSP00000221232.5, ENST00000221232.11
      Conserved Domains (2) summary
      COG5665
      Location:12 → 751
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 229
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      54137762..54155681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438877.1 → XP_047294833.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    2. XM_047438878.1 → XP_047294834.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_047438866.1 → XP_047294822.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_047438874.1 → XP_047294830.1  CCR4-NOT transcription complex subunit 3 isoform X5

    5. XM_047438879.1 → XP_047294835.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    6. XM_005278280.3 → XP_005278337.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_005278337.1

      UniProtKB/TrEMBL
      B7Z6J7
      Conserved Domains (2) summary
      COG5665
      Location:12 → 769
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 230
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    7. XM_047438872.1 → XP_047294828.1  CCR4-NOT transcription complex subunit 3 isoform X5

    8. XM_047438867.1 → XP_047294823.1  CCR4-NOT transcription complex subunit 3 isoform X2

    9. XM_047438875.1 → XP_047294831.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76
      Related
      ENSP00000351159.4, ENST00000358389.7

    10. XM_005278279.3 → XP_005278336.1  CCR4-NOT transcription complex subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_005278336.1

      UniProtKB/TrEMBL
      B7Z6J7
      Conserved Domains (2) summary
      COG5665
      Location:12 → 769
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 230
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    11. XM_005278282.4 → XP_005278339.1  CCR4-NOT transcription complex subunit 3 isoform X5

      See identical proteins and their annotated locations for XP_005278339.1

      UniProtKB/TrEMBL
      B7Z6J7
      Conserved Domains (2) summary
      COG5665
      Location:12 → 752
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 230
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    12. XM_005278281.3 → XP_005278338.1  CCR4-NOT transcription complex subunit 3 isoform X2

      See identical proteins and their annotated locations for XP_005278338.1

      UniProtKB/TrEMBL
      B7Z6J7
      Conserved Domains (2) summary
      COG5665
      Location:12 → 768
      COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
      pfam04065
      Location:3 → 229
      Not3; Not1 N-terminal domain, CCR4-Not complex component

    13. XM_047438869.1 → XP_047294825.1  CCR4-NOT transcription complex subunit 3 isoform X3

    14. XM_047438871.1 → XP_047294827.1  CCR4-NOT transcription complex subunit 3 isoform X4

    15. XM_047438880.1 → XP_047294836.1  CCR4-NOT transcription complex subunit 3 isoform X8

      Related
      ENSP00000496602.1, ENST00000617930.2

    16. XM_047438870.1 → XP_047294826.1  CCR4-NOT transcription complex subunit 3 isoform X4

    17. XM_011526993.4 → XP_011525295.1  CCR4-NOT transcription complex subunit 3 isoform X7

      See identical proteins and their annotated locations for XP_011525295.1

      UniProtKB/TrEMBL
      B7Z6J7
      Conserved Domains (2) summary
      pfam04065
      Location:3 → 230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      cl02384
      Location:625 → 678
      NOT2_3_5; NOT2 / NOT3 / NOT5 family

    18. XM_047438868.1 → XP_047294824.1  CCR4-NOT transcription complex subunit 3 isoform X2

    19. XM_047438873.1 → XP_047294829.1  CCR4-NOT transcription complex subunit 3 isoform X5

    20. XM_047438876.1 → XP_047294832.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003571054.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      112518..130531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329698.1 → XP_054185673.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    2. XM_054329685.1 → XP_054185660.1  CCR4-NOT transcription complex subunit 3 isoform X1

    3. XM_054329694.1 → XP_054185669.1  CCR4-NOT transcription complex subunit 3 isoform X5

    4. XM_054329687.1 → XP_054185662.1  CCR4-NOT transcription complex subunit 3 isoform X2

    5. XM_054329695.1 → XP_054185670.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    6. XM_054329684.1 → XP_054185659.1  CCR4-NOT transcription complex subunit 3 isoform X1

    7. XM_054329693.1 → XP_054185668.1  CCR4-NOT transcription complex subunit 3 isoform X5

    8. XM_054329686.1 → XP_054185661.1  CCR4-NOT transcription complex subunit 3 isoform X2

    9. XM_054329690.1 → XP_054185665.1  CCR4-NOT transcription complex subunit 3 isoform X3

    10. XM_054329692.1 → XP_054185667.1  CCR4-NOT transcription complex subunit 3 isoform X4

    11. XM_054329689.1 → XP_054185664.1  CCR4-NOT transcription complex subunit 3 isoform X3

    12. XM_054329691.1 → XP_054185666.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054329699.1 → XP_054185674.1  CCR4-NOT transcription complex subunit 3 isoform X7

    14. XM_054329697.1 → XP_054185672.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    15. XM_054329688.1 → XP_054185663.1  CCR4-NOT transcription complex subunit 3 isoform X2

    16. XM_054329696.1 → XP_054185671.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NW_003571055.2 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330191.1 → XP_054186166.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054330195.1 → XP_054186170.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054330181.1 → XP_054186156.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054330180.1 → XP_054186155.1  CCR4-NOT transcription complex subunit 3 isoform X1

    5. XM_054330189.1 → XP_054186164.1  CCR4-NOT transcription complex subunit 3 isoform X5

    6. XM_054330183.1 → XP_054186158.1  CCR4-NOT transcription complex subunit 3 isoform X2

    7. XM_054330192.1 → XP_054186167.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    8. XM_054330179.1 → XP_054186154.1  CCR4-NOT transcription complex subunit 3 isoform X1

    9. XM_054330188.1 → XP_054186163.1  CCR4-NOT transcription complex subunit 3 isoform X5

    10. XM_054330182.1 → XP_054186157.1  CCR4-NOT transcription complex subunit 3 isoform X2

    11. XM_054330198.1 → XP_054186173.1  CCR4-NOT transcription complex subunit 3 isoform X8

    12. XM_054330187.1 → XP_054186162.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054330185.1 → XP_054186160.1  CCR4-NOT transcription complex subunit 3 isoform X3

    14. XM_054330197.1 → XP_054186172.1  CCR4-NOT transcription complex subunit 3 isoform X8

    15. XM_054330186.1 → XP_054186161.1  CCR4-NOT transcription complex subunit 3 isoform X4

    16. XM_054330196.1 → XP_054186171.1  CCR4-NOT transcription complex subunit 3 isoform X7

    17. XM_054330184.1 → XP_054186159.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054330190.1 → XP_054186165.1  CCR4-NOT transcription complex subunit 3 isoform X5

    19. XM_054330193.1 → XP_054186168.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    20. XM_054330194.1 → XP_054186169.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NW_003571056.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330492.1 → XP_054186467.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    2. XM_054330478.1 → XP_054186453.1  CCR4-NOT transcription complex subunit 3 isoform X1

    3. XM_054330477.1 → XP_054186452.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054330487.1 → XP_054186462.1  CCR4-NOT transcription complex subunit 3 isoform X5

    5. XM_054330480.1 → XP_054186455.1  CCR4-NOT transcription complex subunit 3 isoform X2

    6. XM_054330490.1 → XP_054186465.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    7. XM_054330476.1 → XP_054186451.1  CCR4-NOT transcription complex subunit 3 isoform X1

    8. XM_054330486.1 → XP_054186461.1  CCR4-NOT transcription complex subunit 3 isoform X5

    9. XM_054330479.1 → XP_054186454.1  CCR4-NOT transcription complex subunit 3 isoform X2

    10. XM_054330496.1 → XP_054186471.1  CCR4-NOT transcription complex subunit 3 isoform X8

    11. XM_054330485.1 → XP_054186460.1  CCR4-NOT transcription complex subunit 3 isoform X4

    12. XM_054330483.1 → XP_054186458.1  CCR4-NOT transcription complex subunit 3 isoform X3

    13. XM_054330495.1 → XP_054186470.1  CCR4-NOT transcription complex subunit 3 isoform X8

    14. XM_054330484.1 → XP_054186459.1  CCR4-NOT transcription complex subunit 3 isoform X4

    15. XM_054330494.1 → XP_054186469.1  CCR4-NOT transcription complex subunit 3 isoform X7

    16. XM_054330481.1 → XP_054186456.1  CCR4-NOT transcription complex subunit 3 isoform X2

    17. XM_054330488.1 → XP_054186463.1  CCR4-NOT transcription complex subunit 3 isoform X5

    18. XM_054330491.1 → XP_054186466.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    19. XM_054330482.1 → XP_054186457.1  CCR4-NOT transcription complex subunit 3 isoform X2

    20. XM_054330489.1 → XP_054186464.1  CCR4-NOT transcription complex subunit 3 isoform X5

    21. XM_054330493.1 → XP_054186468.1  CCR4-NOT transcription complex subunit 3 isoform X9

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NW_003571057.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330739.1 → XP_054186714.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054330743.1 → XP_054186718.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054330729.1 → XP_054186704.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054330737.1 → XP_054186712.1  CCR4-NOT transcription complex subunit 3 isoform X5

    5. XM_054330731.1 → XP_054186706.1  CCR4-NOT transcription complex subunit 3 isoform X2

    6. XM_054330740.1 → XP_054186715.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    7. XM_054330728.1 → XP_054186703.1  CCR4-NOT transcription complex subunit 3 isoform X1

    8. XM_054330736.1 → XP_054186711.1  CCR4-NOT transcription complex subunit 3 isoform X5

    9. XM_054330730.1 → XP_054186705.1  CCR4-NOT transcription complex subunit 3 isoform X2

    10. XM_054330745.1 → XP_054186720.1  CCR4-NOT transcription complex subunit 3 isoform X8

    11. XM_054330734.1 → XP_054186709.1  CCR4-NOT transcription complex subunit 3 isoform X3

    12. XM_054330735.1 → XP_054186710.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054330744.1 → XP_054186719.1  CCR4-NOT transcription complex subunit 3 isoform X7

    14. XM_054330732.1 → XP_054186707.1  CCR4-NOT transcription complex subunit 3 isoform X2

    15. XM_054330738.1 → XP_054186713.1  CCR4-NOT transcription complex subunit 3 isoform X5

    16. XM_054330742.1 → XP_054186717.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    17. XM_054330733.1 → XP_054186708.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054330741.1 → XP_054186716.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NW_003571058.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330969.1 → XP_054186944.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054330971.1 → XP_054186946.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054330960.1 → XP_054186935.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054330967.1 → XP_054186942.1  CCR4-NOT transcription complex subunit 3 isoform X5

    5. XM_054330962.1 → XP_054186937.1  CCR4-NOT transcription complex subunit 3 isoform X2

    6. XM_054330970.1 → XP_054186945.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    7. XM_054330959.1 → XP_054186934.1  CCR4-NOT transcription complex subunit 3 isoform X1

    8. XM_054330966.1 → XP_054186941.1  CCR4-NOT transcription complex subunit 3 isoform X5

    9. XM_054330961.1 → XP_054186936.1  CCR4-NOT transcription complex subunit 3 isoform X2

    10. XM_054330976.1 → XP_054186951.1  CCR4-NOT transcription complex subunit 3 isoform X8

    11. XM_054330964.1 → XP_054186939.1  CCR4-NOT transcription complex subunit 3 isoform X3

    12. XM_054330975.1 → XP_054186950.1  CCR4-NOT transcription complex subunit 3 isoform X8

    13. XM_054330965.1 → XP_054186940.1  CCR4-NOT transcription complex subunit 3 isoform X4

    14. XM_054330974.1 → XP_054186949.1  CCR4-NOT transcription complex subunit 3 isoform X7

    15. XM_054330968.1 → XP_054186943.1  CCR4-NOT transcription complex subunit 3 isoform X5

    16. XM_054330973.1 → XP_054186948.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    17. XM_054330963.1 → XP_054186938.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054330972.1 → XP_054186947.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NW_003571059.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331252.1 → XP_054187227.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054331254.1 → XP_054187229.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054331242.1 → XP_054187217.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054331241.1 → XP_054187216.1  CCR4-NOT transcription complex subunit 3 isoform X1

    5. XM_054331251.1 → XP_054187226.1  CCR4-NOT transcription complex subunit 3 isoform X5

    6. XM_054331244.1 → XP_054187219.1  CCR4-NOT transcription complex subunit 3 isoform X2

    7. XM_054331253.1 → XP_054187228.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    8. XM_054331240.1 → XP_054187215.1  CCR4-NOT transcription complex subunit 3 isoform X1

    9. XM_054331250.1 → XP_054187225.1  CCR4-NOT transcription complex subunit 3 isoform X5

    10. XM_054331243.1 → XP_054187218.1  CCR4-NOT transcription complex subunit 3 isoform X2

    11. XM_054331259.1 → XP_054187234.1  CCR4-NOT transcription complex subunit 3 isoform X8

    12. XM_054331249.1 → XP_054187224.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054331247.1 → XP_054187222.1  CCR4-NOT transcription complex subunit 3 isoform X3

    14. XM_054331258.1 → XP_054187233.1  CCR4-NOT transcription complex subunit 3 isoform X8

    15. XM_054331248.1 → XP_054187223.1  CCR4-NOT transcription complex subunit 3 isoform X4

    16. XM_054331257.1 → XP_054187232.1  CCR4-NOT transcription complex subunit 3 isoform X7

    17. XM_054331245.1 → XP_054187220.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054331255.1 → XP_054187230.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    19. XM_054331246.1 → XP_054187221.1  CCR4-NOT transcription complex subunit 3 isoform X2

    20. XM_054331256.1 → XP_054187231.1  CCR4-NOT transcription complex subunit 3 isoform X10

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NW_003571060.1 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331525.1 → XP_054187500.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054331528.1 → XP_054187503.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054331517.1 → XP_054187492.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054331516.1 → XP_054187491.1  CCR4-NOT transcription complex subunit 3 isoform X1

    5. XM_054331523.1 → XP_054187498.1  CCR4-NOT transcription complex subunit 3 isoform X5

    6. XM_054331519.1 → XP_054187494.1  CCR4-NOT transcription complex subunit 3 isoform X2

    7. XM_054331526.1 → XP_054187501.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    8. XM_054331515.1 → XP_054187490.1  CCR4-NOT transcription complex subunit 3 isoform X1

    9. XM_054331522.1 → XP_054187497.1  CCR4-NOT transcription complex subunit 3 isoform X5

    10. XM_054331518.1 → XP_054187493.1  CCR4-NOT transcription complex subunit 3 isoform X2

    11. XM_054331520.1 → XP_054187495.1  CCR4-NOT transcription complex subunit 3 isoform X3

    12. XM_054331521.1 → XP_054187496.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054331529.1 → XP_054187504.1  CCR4-NOT transcription complex subunit 3 isoform X7

    14. XM_054331524.1 → XP_054187499.1  CCR4-NOT transcription complex subunit 3 isoform X5

    15. XM_054331527.1 → XP_054187502.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_8

    Genomic

    1. NW_003571061.2 Reference GRCh38.p14 ALT_REF_LOCI_8

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333570.1 → XP_054189545.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    2. XM_054333556.1 → XP_054189531.1  CCR4-NOT transcription complex subunit 3 isoform X1

    3. XM_054333565.1 → XP_054189540.1  CCR4-NOT transcription complex subunit 3 isoform X5

    4. XM_054333558.1 → XP_054189533.1  CCR4-NOT transcription complex subunit 3 isoform X2

    5. XM_054333568.1 → XP_054189543.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    6. XM_054333555.1 → XP_054189530.1  CCR4-NOT transcription complex subunit 3 isoform X1

    7. XM_054333564.1 → XP_054189539.1  CCR4-NOT transcription complex subunit 3 isoform X5

    8. XM_054333557.1 → XP_054189532.1  CCR4-NOT transcription complex subunit 3 isoform X2

    9. XM_054333563.1 → XP_054189538.1  CCR4-NOT transcription complex subunit 3 isoform X4

    10. XM_054333561.1 → XP_054189536.1  CCR4-NOT transcription complex subunit 3 isoform X3

    11. XM_054333573.1 → XP_054189548.1  CCR4-NOT transcription complex subunit 3 isoform X8

    12. XM_054333562.1 → XP_054189537.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054333572.1 → XP_054189547.1  CCR4-NOT transcription complex subunit 3 isoform X7

    14. XM_054333559.1 → XP_054189534.1  CCR4-NOT transcription complex subunit 3 isoform X2

    15. XM_054333566.1 → XP_054189541.1  CCR4-NOT transcription complex subunit 3 isoform X5

    16. XM_054333571.1 → XP_054189546.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    17. XM_054333560.1 → XP_054189535.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054333567.1 → XP_054189542.1  CCR4-NOT transcription complex subunit 3 isoform X5

    19. XM_054333569.1 → XP_054189544.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Reference GRCh38.p14 ALT_REF_LOCI_9

    Genomic

    1. NT_187693.1 Reference GRCh38.p14 ALT_REF_LOCI_9

      Range
      112518..130532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333668.1 → XP_054189643.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054333671.1 → XP_054189646.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054333658.1 → XP_054189633.1  CCR4-NOT transcription complex subunit 3 isoform X1

    4. XM_054333656.1 → XP_054189631.1  CCR4-NOT transcription complex subunit 3 isoform X1

    5. XM_054333666.1 → XP_054189641.1  CCR4-NOT transcription complex subunit 3 isoform X5

    6. XM_054333660.1 → XP_054189635.1  CCR4-NOT transcription complex subunit 3 isoform X2

    7. XM_054333669.1 → XP_054189644.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    8. XM_054333657.1 → XP_054189632.1  CCR4-NOT transcription complex subunit 3 isoform X1

    9. XM_054333665.1 → XP_054189640.1  CCR4-NOT transcription complex subunit 3 isoform X5

    10. XM_054333659.1 → XP_054189634.1  CCR4-NOT transcription complex subunit 3 isoform X2

    11. XM_054333675.1 → XP_054189650.1  CCR4-NOT transcription complex subunit 3 isoform X8

    12. XM_054333664.1 → XP_054189639.1  CCR4-NOT transcription complex subunit 3 isoform X4

    13. XM_054333662.1 → XP_054189637.1  CCR4-NOT transcription complex subunit 3 isoform X3

    14. XM_054333674.1 → XP_054189649.1  CCR4-NOT transcription complex subunit 3 isoform X8

    15. XM_054333663.1 → XP_054189638.1  CCR4-NOT transcription complex subunit 3 isoform X4

    16. XM_054333673.1 → XP_054189648.1  CCR4-NOT transcription complex subunit 3 isoform X7

    17. XM_054333661.1 → XP_054189636.1  CCR4-NOT transcription complex subunit 3 isoform X2

    18. XM_054333667.1 → XP_054189642.1  CCR4-NOT transcription complex subunit 3 isoform X5

    19. XM_054333672.1 → XP_054189647.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    20. XM_054333670.1 → XP_054189645.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      57217961..57235947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321095.1 → XP_054177070.1  CCR4-NOT transcription complex subunit 3 isoform X5

    2. XM_054321098.1 → XP_054177073.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    3. XM_054321099.1 → XP_054177074.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    4. XM_054321082.1 → XP_054177057.1  CCR4-NOT transcription complex subunit 3 isoform X1

    5. XM_054321094.1 → XP_054177069.1  CCR4-NOT transcription complex subunit 3 isoform X5

    6. XM_054321100.1 → XP_054177075.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    7. XM_054321081.1 → XP_054177056.1  CCR4-NOT transcription complex subunit 3 isoform X1

    8. XM_054321092.1 → XP_054177067.1  CCR4-NOT transcription complex subunit 3 isoform X5

    9. XM_054321084.1 → XP_054177059.1  CCR4-NOT transcription complex subunit 3 isoform X2

    10. XM_054321096.1 → XP_054177071.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    11. XM_054321080.1 → XP_054177055.1  CCR4-NOT transcription complex subunit 3 isoform X1

    12. XM_054321091.1 → XP_054177066.1  CCR4-NOT transcription complex subunit 3 isoform X5

    13. XM_054321083.1 → XP_054177058.1  CCR4-NOT transcription complex subunit 3 isoform X2

    14. XM_054321088.1 → XP_054177063.1  CCR4-NOT transcription complex subunit 3 isoform X3

    15. XM_054321103.1 → XP_054177078.1  CCR4-NOT transcription complex subunit 3 isoform X8

    16. XM_054321090.1 → XP_054177065.1  CCR4-NOT transcription complex subunit 3 isoform X4

    17. XM_054321087.1 → XP_054177062.1  CCR4-NOT transcription complex subunit 3 isoform X3

    18. XM_054321102.1 → XP_054177077.1  CCR4-NOT transcription complex subunit 3 isoform X8

    19. XM_054321089.1 → XP_054177064.1  CCR4-NOT transcription complex subunit 3 isoform X4

    20. XM_054321101.1 → XP_054177076.1  CCR4-NOT transcription complex subunit 3 isoform X7

    21. XM_054321085.1 → XP_054177060.1  CCR4-NOT transcription complex subunit 3 isoform X2

    22. XM_054321093.1 → XP_054177068.1  CCR4-NOT transcription complex subunit 3 isoform X5

    23. XM_054321097.1 → XP_054177072.1  CCR4-NOT transcription complex subunit 3 isoform X6

      UniProtKB/Swiss-Prot
      O75175, Q9NZN7, Q9UF76

    24. XM_054321086.1 → XP_054177061.1  CCR4-NOT transcription complex subunit 3 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75175.1 GenPept UniProtKB/Swiss-Prot:O75175

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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