Bpifb1 BPI fold containing family B, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bpifb1provided by MGI
Official Full Name: BPI fold containing family B, member 1provided by MGI
Primary source: MGI:MGI:2137431
See related: Ensembl:ENSMUSG00000027485 AllianceGenome:MGI:2137431
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lplunc1
Summary: Predicted to enable lipid binding activity. Predicted to be involved in innate immune response in mucosa and negative regulation of toll-like receptor 4 signaling pathway. Predicted to act upstream of or within innate immune response. Predicted to be located in extracellular region. Is expressed in alimentary system; male reproductive gland or organ; primitive streak; respiratory system; and thymus. Orthologous to human BPIFB1 (BPI fold containing family B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 138.8), lung adult (RPKM 47.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 76.23 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (154032738..154062263)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (154190818..154220343)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.
Title: BPIFB1 loss alters airway mucus properties and diminishes mucociliary clearance.
BPIFB1 is a novel regulator of MUC5B expression in airway mucosa.
Title: Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1.
Bpifb1 mRNA is upregulated in parotid acinar cells in NOD mice, but its expression is not related to the onset of diabetes. These findings suggest that high expression levels of Bpifb1 might predict disease traits before the onset of autoimmunity.
Title: Upregulation of Bpifb1 expression in the parotid glands of non-obese diabetic mice.
Autoimmunity targeting the lung-specific antigen BPIFB1 may contribute to the pathogenesis of interstitial lung disease.
Title: BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease.
Knowledge of the complex expression patterns of BPIF proteins in these regions will allow the use of tractable mouse models of disease to dissect their function.
Title: Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice.
CETP inhibitor torcetrapib promotes reverse cholesterol transport in obese insulin-resistant CETP-ApoB100 transgenic mice
Title: CETP inhibitor torcetrapib promotes reverse cholesterol transport in obese insulin-resistant CETP-ApoB100 transgenic mice.
a novel gene LPlunc1, a member of BPI/PLUNC gene superfamily, which is asymmetrically expressed in the developing mouse node [LPlunc1 protein]
Title: Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

Scgb1a1 (e-PCR), detects polymorphism
- UniSTS:499112

RH134311 (e-PCR)
- UniSTS:217593

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: BPI fold-containing family B member 1

Names: long palate, lung and nasal epithelium carcinoma associated 1; long palate, lung and nasal epithelium carcinoma-associated protein 1; von Ebner minor salivary gland protein; von Ebner minor salivary protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012392.1 → NP_001012392.1 BPI fold-containing family B member 1 precursor

See identical proteins and their annotated locations for NP_001012392.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC060982, U46068

Consensus CDS

CCDS16927.1

UniProtKB/Swiss-Prot

A2AJD5, Q497Q1, Q4VC32, Q61114

Related

ENSMUSP00000080501.5, ENSMUST00000081816.11

Conserved Domains (2) summary

cd00025
Location:26 → 261

BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

cd00026
Location:278 → 474

BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
NM_153418.2 → NP_700467.2 BPI fold-containing family B member 1 precursor

See identical proteins and their annotated locations for NP_700467.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

U46068

Consensus CDS

CCDS16927.1

UniProtKB/Swiss-Prot

A2AJD5, Q497Q1, Q4VC32, Q61114

Related

ENSMUSP00000028987.7, ENSMUST00000028987.7

Conserved Domains (2) summary

cd00025
Location:26 → 261

BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

cd00026
Location:278 → 474

BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...