U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Klk13 kallikrein related-peptidase 13 [ Mus musculus (house mouse) ]

    Gene ID: 626834, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Klk13provided by MGI
    Official Full Name
    kallikrein related-peptidase 13provided by MGI
    Primary source
    MGI:MGI:3615275
    See related
    Ensembl:ENSMUSG00000054046 AllianceGenome:MGI:3615275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mGk-13; Egfbp-2
    Summary
    Kallikreins are serine proteases encoded by a cluster of highly related genes on chromosome 7. When genomic sequence became available, it was possible to clarify the gene-to-sequence relationship for this family. Until January, 2006, NM_010115 was called kallikrein 13. After that time, NM_001039042 was called Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach adult (RPKM 14.7) and lung adult (RPKM 5.4) See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43361991..43377288)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43712567..43727864)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11351 Neighboring gene cytosolic thiouridylase subunit 1 Neighboring gene kallikrein related-peptidase 14 Neighboring gene RIKEN cDNA 2310002F09 gene Neighboring gene kallikrein related-peptidase 12

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The presence of two types of prorenin converting enzymes in the mouse submandibular gland. Kim WS, et al. FEBS Lett, 1991 Nov 18. PMID 1959648
    2. Mouse submandibular gland prorenin-converting enzyme is a member of glandular kallikrein family. Kim WS, et al. J Biol Chem, 1991 Oct 15. PMID 1918045
    3. Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. Yao C, et al. J Biol Chem, 2006 Mar 24. PMID 16423834
    4. Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins. Drinkwater CC, et al. Biochemistry, 1987 Oct 20. PMID 3322387
    5. Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22). Kikkawa Y, et al. Biochim Biophys Acta, 1998 Jan 15. PMID 9507064

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the submandibular gland of mice
      Title: Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    kallikrein-13
    Names
    kallikrein 13

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039042.2 → NP_001034131.2  kallikrein-13 precursor

      See identical proteins and their annotated locations for NP_001034131.2

      Status: VALIDATED

      Source sequence(s)
      BC063763
      Consensus CDS
      CCDS39933.1
      UniProtKB/TrEMBL
      Q8CGR6
      Related
      ENSMUSP00000065308.7, ENSMUST00000066834.8
      Conserved Domains (1) summary
      cd00190
      Location:39 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43361991..43377288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541056.4 → XP_006541119.1  kallikrein-13 isoform X1

      See identical proteins and their annotated locations for XP_006541119.1

      UniProtKB/TrEMBL
      Q8CGR6
      Conserved Domains (1) summary
      cd00190
      Location:39 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_006541055.4 → XP_006541118.1  kallikrein-13 isoform X1

      See identical proteins and their annotated locations for XP_006541118.1

      UniProtKB/TrEMBL
      Q8CGR6
      Conserved Domains (1) summary
      cd00190
      Location:39 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. XM_011250887.3 → XP_011249189.1  kallikrein-13 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:39 → 168
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. XM_017322442.1 → XP_017177931.1  kallikrein-13 isoform X3

      Conserved Domains (1) summary
      smart00020
      Location:18 → 156
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous