Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnh6provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 6provided by MGI
Primary source: MGI:MGI:2684139
See related: Ensembl:ENSMUSG00000001901 AllianceGenome:MGI:2684139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: m-erg2
Summary: Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; retina; and skin. Used to study glucose metabolism disease. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.87 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105898871..105926421)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (106008044..106035595)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes.
Title: KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes.
KCNH6 is essential for insulin secretion by regulating intracellular ER Ca[2+] store.
Title: KCNH6 is essential for insulin secretion by regulating intracellular ER Ca(2+) store.
KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
Title: KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
Title: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism.
Title: Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism.
KCNH6 protects pancreatic beta-cells from endoplasmic reticulum stress and apoptosis.
Title: KCNH6 protects pancreatic β-cells from endoplasmic reticulum stress and apoptosis.
dysfunction of KCNH6 causes overstimulation of insulin secretion in the short term and beta cell failure in the long term.
Title: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion.
erg2 gene expression pattern in the developing embryo
Title: Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.
One of the abnormally elevated genes in Egr2Lo/Lo Schwann cells, Sox2, encodes a transcription factor that is crucial for maintenance of neural stem cell pluripotency.
Title: Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3)

General gene information

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Markers

D11Mit201 (e-PCR), detects polymorphism
- UniSTS:126402

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane repolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily H member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037712.2 → NP_001032801.1 potassium voltage-gated channel subfamily H member 6

See identical proteins and their annotated locations for NP_001032801.1

Status: VALIDATED

Source sequence(s)

AL596331

Consensus CDS

CCDS25545.1

UniProtKB/TrEMBL

B1AR82, Q32ME0

Related

ENSMUSP00000001965.8, ENSMUST00000001965.14

Conserved Domains (6) summary

COG0664
Location:588 → 701

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:594 → 705

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:41 → 132

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:296 → 520

Ion_trans; Ion transport protein

pfam07885
Location:463 → 517

Ion_trans_2; Ion channel

pfam13426
Location:29 → 132

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

105898871..105926421

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532554.4 → XP_006532617.1 potassium voltage-gated channel subfamily H member 6 isoform X4

UniProtKB/TrEMBL

M0QW64

Related

ENSMUSP00000137675.2, ENSMUST00000145539.2

Conserved Domains (2) summary

PLN03192
Location:259 → 698

PLN03192; Voltage-dependent potassium channel; Provisional

pfam13426
Location:29 → 132

PAS_9; PAS domain
XM_006532550.4 → XP_006532613.1 potassium voltage-gated channel subfamily H member 6 isoform X1

UniProtKB/TrEMBL

B1AR82

Conserved Domains (2) summary

PLN03192
Location:259 → 698

PLN03192; Voltage-dependent potassium channel; Provisional

pfam13426
Location:29 → 132

PAS_9; PAS domain
XM_030245696.2 → XP_030101556.1 potassium voltage-gated channel subfamily H member 6 isoform X2

UniProtKB/TrEMBL

B1AR82

Conserved Domains (2) summary

PLN03192
Location:259 → 698

PLN03192; Voltage-dependent potassium channel; Provisional

pfam13426
Location:29 → 132

PAS_9; PAS domain
XM_006532551.5 → XP_006532614.1 potassium voltage-gated channel subfamily H member 6 isoform X3

UniProtKB/TrEMBL

B1AR82

Conserved Domains (1) summary

PLN03192
Location:136 → 575

PLN03192; Voltage-dependent potassium channel; Provisional