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    Ly6g6e lymphocyte antigen 6 family member G6E [ Mus musculus (house mouse) ]

    Gene ID: 70274, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ly6g6eprovided by MGI
    Official Full Name
    lymphocyte antigen 6 family member G6Eprovided by MGI
    Primary source
    MGI:MGI:1917524
    See related
    Ensembl:ENSMUSG00000013766 AllianceGenome:MGI:1917524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G6e; 2310011I02Rik
    Summary
    Enables acetylcholine receptor activator activity and acetylcholine receptor binding activity. Acts upstream of or within acetylcholine receptor signaling pathway and desensitization of G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in embryo; liver; lung; metanephros; and testis. Orthologous to human LY6G6E (lymphocyte antigen 6 family member G6E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 36.3), colon adult (RPKM 18.8) and 8 other tissues See more
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    Genomic context

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    Location:
    17 B1; 17 18.59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35295843..35297781)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35076868..35078804)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene G6b opposite strand Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene STARR-seq mESC enhancer starr_42446 Neighboring gene lymphocyte antigen 6 family member G6F Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. Mallya M, et al. Genomics, 2002 Jul. PMID 12079290
    2. Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family. Wu M, et al. J Biol Chem, 2015 Oct 2. PMID 26276394, Free PMC Article
    3. Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands. Mallya M, et al. Protein Sci, 2006 Oct. PMID 17008713, Free PMC Article
    4. A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. Coveney D, et al. Gene Expr Patterns, 2007 Jan. PMID 16844427
    5. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Loughner CL, et al. Hum Genomics, 2016 Apr 21. PMID 27098205, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lynx2 and Ly6g6e have roles in intracellular trafficking and allosteric potentiation of alpha4beta2 nAChRs, respectively
      Title: Mechanisms of inhibition and potentiation of α4β2 nicotinic acetylcholine receptors by members of the Ly6 protein family.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in desensitization of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within desensitization of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lymphocyte antigen 6G6e
    Names
    lymphocyte antigen 6 complex G6E
    lymphocyte antigen 6 complex locus protein G6e
    lymphocyte antigen 6 complex, locus G6E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405155.1 → NP_001392084.1  lymphocyte antigen 6G6e isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Related
      ENSMUSP00000134073.2, ENSMUST00000172678.8

    2. NM_001405156.1 → NP_001392085.1  lymphocyte antigen 6G6e isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC087117

    3. NM_001405157.1 → NP_001392086.1  lymphocyte antigen 6G6e isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC087117
      UniProtKB/TrEMBL
      G3UXD4
      Related
      ENSMUSP00000133645.2, ENSMUST00000172494.8

    4. NM_027366.2 → NP_081642.1  lymphocyte antigen 6G6e isoform a precursor

      See identical proteins and their annotated locations for NP_081642.1

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS28679.1
      UniProtKB/Swiss-Prot
      Q8K1T6
      Related
      ENSMUSP00000013910.5, ENSMUST00000013910.5
      Conserved Domains (1) summary
      pfam01064
      Location:28 → 104
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35295843..35297781
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524887.5 → XP_006524950.1  lymphocyte antigen 6G6e isoform X1

      See identical proteins and their annotated locations for XP_006524950.1

      UniProtKB/Swiss-Prot
      Q8K1T6, Q9D7E5
      Conserved Domains (1) summary
      pfam01064
      Location:28 → 136
      Activin_recp; Activin types I and II receptor domain

    2. XM_006524886.4 → XP_006524949.1  lymphocyte antigen 6G6e isoform X1

      See identical proteins and their annotated locations for XP_006524949.1

      UniProtKB/Swiss-Prot
      Q8K1T6, Q9D7E5
      Conserved Domains (1) summary
      pfam01064
      Location:28 → 136
      Activin_recp; Activin types I and II receptor domain

    3. XM_030250043.1 → XP_030105903.1  lymphocyte antigen 6G6e isoform X1

      UniProtKB/Swiss-Prot
      Q8K1T6, Q9D7E5
      Related
      ENSMUSP00000133753.2, ENSMUST00000172959.2
      Conserved Domains (1) summary
      pfam01064
      Location:28 → 136
      Activin_recp; Activin types I and II receptor domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003720.1: Suppressed sequence

      Description
      NM_001003720.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1T6.1 GenPept UniProtKB/Swiss-Prot:Q8K1T6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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