Opn5 opsin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Opn5provided by MGI
Official Full Name: opsin 5provided by MGI
Primary source: MGI:MGI:2662912
See related: Ensembl:ENSMUSG00000043972 AllianceGenome:MGI:2662912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PGR12; Gpr136; TMEM13; Neuropsin
Summary: Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 17 19.65 cM; 17 B3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (42867670..42922321, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (42556779..42611430, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
Title: Neuropsin promotes hippocampal synaptogenesis by regulating the expression and cleavage of L1CAM.
Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
Title: Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.
Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
Title: Expression of osteopontin-5 splice variant in the mouse primary and metastatic breast cancer cells.
Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
Title: Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.
Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
Title: Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
Neuropsin in mental health.
Title: Neuropsin in mental health.
Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
Title: Wounding Induces Facultative Opn5-Dependent Circadian Photoreception in the Murine Cornea.
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
Title: Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
The study identify violet light as a developmental timing cue that, via an OPN5-dopamine pathway, regulates optic axis clearance in preparation for visual function.
Title: An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.
These results suggest that the neuropsin-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin-expressing interneurons, and that neuropsin regulates E/I balance and gamma oscillations through NRG1-ErbB4 signaling toward parvalbumin-expressing interneurons.
Title: Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (5) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495717

BB453217 (e-PCR)
- UniSTS:209309

NoName (e-PCR)
- UniSTS:488650

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-cis retinal binding	IDA Inferred from Direct Assay more info	PubMed
enables 11-cis retinal binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables 11-cis retinal binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction, UV	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: opsin-5

Names: G protein-coupled receptor 136; G-protein coupled receptor PGR12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181753.4 → NP_861418.2 opsin-5

See identical proteins and their annotated locations for NP_861418.2

Status: PROVISIONAL

Source sequence(s)

AC110552

Consensus CDS

CCDS37619.1

UniProtKB/Swiss-Prot

Q059L5, Q6VZZ7, Q7TQP1, Q80T51, Q8BYI2

Related

ENSMUSP00000063542.7, ENSMUST00000068355.8

Conserved Domains (1) summary

pfam00001
Location:50 → 306

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

42867670..42922321 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524453.1 → XP_006524516.1 opsin-5 isoform X1

Conserved Domains (1) summary

cd15074
Location:7 → 278

7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017317518.1 → XP_017173007.1 opsin-5 isoform X2

Conserved Domains (2) summary

cd14964
Location:35 → 61

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:34 → 140

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily