Akr1c6 aldo-keto reductase family 1, member C6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1c6provided by MGI
Official Full Name: aldo-keto reductase family 1, member C6provided by MGI
Primary source: MGI:MGI:1933427
See related: Ensembl:ENSMUSG00000021210 AllianceGenome:MGI:1933427
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Akr1c1; Hsd17b5; 3alpha-HSD
Summary: Enables estradiol 17-beta-dehydrogenase activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1) and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 103.4) See more
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Genomic context

Location:: 13 A1; 13 2.48 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (4484354..4507529)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (4434311..4457530)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A catalysis-independent role for AKR1C3 on AR activity via Siah2 has been identified.
Title: The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.
17beta-HSD 5 gene is up-regulated in both male and female developing lungs of the fetal mouse.
Title: 17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.
This study evaluates 5alpha-R type I and 3alpha-HSD mRNA expression level in mouse brain by using in situ hybridization.
Title: Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225363

Akr1c6 (e-PCR), detects polymorphism
- UniSTS:496760

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables Delta4-3-oxosteroid 5beta-reductase activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase (B-specific) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables chlordecone reductase activity	ISO Inferred from Sequence Orthology more info
enables dihydrotestosterone 17-beta-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA Inferred from Direct Assay more info	PubMed
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables ketoreductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables phenanthrene 9,10-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticosteroid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: estradiol 17 beta-dehydrogenase 5

Names: 17-beta-HSD 5; 17HSD type 5; aldo-keto reductase family 1, member C1 (aldehyde reductase); estradiol 17-beta-dehydrogenase (A-specific); hydroxysteroid 17-beta dehydrogenase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418783.1 → NP_001405712.1 estradiol 17 beta-dehydrogenase 5 isoform 2

Status: VALIDATED

Source sequence(s)

AC166056
NM_001418784.1 → NP_001405713.1 estradiol 17 beta-dehydrogenase 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC166056
NM_030611.4 → NP_085114.1 estradiol 17 beta-dehydrogenase 5 isoform 1

See identical proteins and their annotated locations for NP_085114.1

Status: VALIDATED

Source sequence(s)

AC166056

Consensus CDS

CCDS26223.1

UniProtKB/Swiss-Prot

P70694

UniProtKB/TrEMBL

Q3UEM0

Related

ENSMUSP00000021630.9, ENSMUST00000021630.15

Conserved Domains (2) summary

COG0656
Location:5 → 323

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 298

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]