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    Mtcl1 microtubule crosslinking factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 68617, updated on 12-May-2024

    Summary

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    Official Symbol
    Mtcl1provided by MGI
    Official Full Name
    microtubule crosslinking factor 1provided by MGI
    Primary source
    MGI:MGI:1915867
    See related
    Ensembl:ENSMUSG00000052105 AllianceGenome:MGI:1915867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Soga2; Ccdc165; Kiaa0802; t8219b25; mKIAA0802; D130071O13; 1110012J17Rik
    Summary
    Enables microtubule binding activity and protein homodimerization activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in several cellular components, including apicolateral plasma membrane; cytoskeleton; and lateral plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; limb segment; metanephros; and neural ectoderm. Orthologous to human MTCL1 (microtubule crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 17.8), lung adult (RPKM 10.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1; 17 35.3 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66643975..66760672, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66336980..66449806, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20742 Neighboring gene STARR-seq mESC enhancer starr_43046 Neighboring gene STARR-seq mESC enhancer starr_43047 Neighboring gene periphilin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43048 Neighboring gene STARR-seq mESC enhancer starr_43049 Neighboring gene STARR-seq mESC enhancer starr_43051 Neighboring gene STARR-seq mESC enhancer starr_43052 Neighboring gene STARR-seq mESC enhancer starr_43061 Neighboring gene STARR-seq mESC enhancer starr_43062 Neighboring gene predicted gene 4705 Neighboring gene STARR-seq mESC enhancer starr_43065 Neighboring gene STARR-seq mESC enhancer starr_43067 Neighboring gene STARR-seq mESC enhancer starr_43070 Neighboring gene VISTA enhancer mm1499 Neighboring gene STARR-seq mESC enhancer starr_43072 Neighboring gene RAB12, member RAS oncogene family Neighboring gene predicted gene, 41608 Neighboring gene STARR-seq mESC enhancer starr_43077 Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene thymocyte selection associated family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MTCL1 plays an essential role in maintaining Purkinje neuron axon initial segment. Satake T, et al. EMBO J, 2017 May 2. PMID 28283581, Free PMC Article
    2. The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells. Sato Y, et al. J Cell Sci, 2013 Oct 15. PMID 23902687
    3. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article
    4. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77963

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apicolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apicolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    microtubule cross-linking factor 1
    Names
    PAR-1-interacting protein
    SOGA family member 2
    coiled-coil domain-containing protein 165
    protein SOGA2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114098.2 → NP_001107570.1  microtubule cross-linking factor 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      CT010496, CT025601
      Consensus CDS
      CCDS50168.1
      UniProtKB/TrEMBL
      H3BL83
      Related
      ENSMUSP00000094894.4, ENSMUST00000097291.10
      Conserved Domains (5) summary
      pfam00261
      Location:338 → 543
      Tropomyosin; Tropomyosin
      pfam10812
      Location:123 → 182
      DUF2561; Protein of unknown function (DUF2561)
      pfam11365
      Location:622 → 714
      DUF3166; Protein of unknown function (DUF3166)
      pfam13863
      Location:432 → 533
      DUF4200; Domain of unknown function (DUF4200)
      pfam14818
      Location:1220 → 1341
      DUF4482; Domain of unknown function (DUF4482)

    2. NM_172963.4 → NP_766551.3  microtubule cross-linking factor 1 isoform 2

      See identical proteins and their annotated locations for NP_766551.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' region, which results in a downstream translation termination codon, compared to variant 1. The resulting isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK147205, BP760436
      Consensus CDS
      CCDS28946.2
      UniProtKB/Swiss-Prot
      Q3UHU5, Q6PAM2, Q80TR7
      Related
      ENSMUSP00000083899.6, ENSMUST00000086693.12
      Conserved Domains (5) summary
      pfam00261
      Location:338 → 543
      Tropomyosin; Tropomyosin
      pfam10812
      Location:123 → 182
      DUF2561; Protein of unknown function (DUF2561)
      pfam11365
      Location:622 → 714
      DUF3166; Protein of unknown function (DUF3166)
      pfam13863
      Location:432 → 533
      DUF4200; Domain of unknown function (DUF4200)
      pfam14818
      Location:1220 → 1341
      DUF4482; Domain of unknown function (DUF4482)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66643975..66760672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524849.4 → XP_006524912.1  microtubule cross-linking factor 1 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:337 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11365
      Location:658 → 750
      SOGA; Protein SOGA
      pfam14818
      Location:1297 → 1418
      DUF4482; Domain of unknown function (DUF4482)

    2. XM_011246587.4 → XP_011244889.1  microtubule cross-linking factor 1 isoform X7

      UniProtKB/TrEMBL
      H3BL83
      Related
      ENSMUSP00000135690.2, ENSMUST00000177034.2
      Conserved Domains (5) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:340 → 648
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:330 → 1103
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam11365
      Location:622 → 714
      SOGA; Protein SOGA
      pfam14818
      Location:1261 → 1382
      DUF4482; Domain of unknown function (DUF4482)

    3. XM_036160766.1 → XP_036016659.1  microtubule cross-linking factor 1 isoform X6

      Conserved Domains (5) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:340 → 659
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:367 → 1277
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam11365
      Location:633 → 725
      SOGA; Protein SOGA
      pfam14818
      Location:1231 → 1352
      DUF4482; Domain of unknown function (DUF4482)

    4. XM_006524853.5 → XP_006524916.1  microtubule cross-linking factor 1 isoform X4

      Conserved Domains (4) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:337 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11365
      Location:658 → 750
      SOGA; Protein SOGA
      pfam14818
      Location:1256 → 1377
      DUF4482; Domain of unknown function (DUF4482)

    5. XM_017317622.3 → XP_017173111.1  microtubule cross-linking factor 1 isoform X8

      Conserved Domains (4) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:337 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11365
      Location:658 → 750
      SOGA; Protein SOGA
      pfam14818
      Location:1256 → 1377
      DUF4482; Domain of unknown function (DUF4482)

    6. XM_006524856.4 → XP_006524919.1  microtubule cross-linking factor 1 isoform X5

      UniProtKB/TrEMBL
      H3BL83
      Conserved Domains (4) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:337 → 693
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam11365
      Location:658 → 750
      SOGA; Protein SOGA
      pfam14818
      Location:1297 → 1418
      DUF4482; Domain of unknown function (DUF4482)

    7. XM_036160768.1 → XP_036016661.1  microtubule cross-linking factor 1 isoform X9

      Conserved Domains (3) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG0419
      Location:338 → 780
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam14818
      Location:731 → 852
      DUF4482; Domain of unknown function (DUF4482)

    8. XM_006524852.5 → XP_006524915.1  microtubule cross-linking factor 1 isoform X3

      Conserved Domains (5) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:340 → 648
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:330 → 1103
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam11365
      Location:622 → 714
      SOGA; Protein SOGA
      pfam14818
      Location:1261 → 1382
      DUF4482; Domain of unknown function (DUF4482)

    9. XM_006524851.5 → XP_006524914.1  microtubule cross-linking factor 1 isoform X2

      Conserved Domains (5) summary
      PHA03247
      Location:13 → 317
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:340 → 659
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam02463
      Location:330 → 1114
      SMC_N; RecF/RecN/SMC N terminal domain
      pfam11365
      Location:633 → 725
      SOGA; Protein SOGA
      pfam14818
      Location:1272 → 1393
      DUF4482; Domain of unknown function (DUF4482)

    RNA

    1. XR_001782108.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UHU5.1 GenPept UniProtKB/Swiss-Prot:Q3UHU5

    Gene LinkOut

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