RNF10 ring finger protein 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF10provided by HGNC
Official Full Name: ring finger protein 10provided by HGNC
Primary source: HGNC:HGNC:10055
See related: Ensembl:ENSG00000022840 MIM:615998; AllianceGenome:HGNC:10055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RIE2
Summary: The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 52.4), bone marrow (RPKM 51.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (120534356..120577588)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (120523536..120566717)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120972159..121015391)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
Title: CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.
The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
Title: The E3 ubiquitin ligase RNF10 modifies 40S ribosomal subunits of ribosomes compromised in translation.
Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
Title: Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation.
CYB5A, which has a role in stearyl-CoA-desaturase activity, and RNF10, with an unknown role in weight regulating pathways, associated with adiposity and nominally increased the risk for T2D in American Indians.
Title: Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.
RNF10 is a trans-acting protein regulating MAG expression and is required for myelin formation.
Title: A novel function of RING finger protein 10 in transcriptional regulation of the myelin-associated glycoprotein gene and myelin formation in Schwann cells.
MEOX2 and Meox2 binding to RNF10 protein was characterized.
Title: Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
New susceptibility loci associated with kidney disease in type 1 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of ring finger protein 10 (RNF10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17496 (e-PCR)
- UniSTS:46125

SGC35167 (e-PCR)
- UniSTS:63844

SHGC-33949 (e-PCR)
- UniSTS:79733

RH45155 (e-PCR)
- UniSTS:48512

D12S1173E (e-PCR)
- UniSTS:151454

D12S1196E (e-PCR)
- UniSTS:151460

RNF10_792 (e-PCR)
- UniSTS:277675

RNF10_V128 (e-PCR)
- UniSTS:277675

SHGC-64103 (e-PCR)
- UniSTS:36787

AA675014 (e-PCR)
- UniSTS:159429

A007E11 (e-PCR)
- UniSTS:60614

D12S1147E (e-PCR)
- UniSTS:55522

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of Schwann cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynapse to nucleus signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF10

Names: epididymis secretory sperm binding protein

NP_001317403.1

EC 2.3.2.27

NP_055683.3

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330474.2 → NP_001317403.1 E3 ubiquitin-protein ligase RNF10 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer, but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AB027196, BQ015862, BU184035, DA956437, HY376488

Consensus CDS

CCDS81746.1

UniProtKB/TrEMBL

B3KSN5, B3KUR9

Related

ENSP00000415682.2, ENST00000413266.6

Conserved Domains (1) summary

pfam13923
Location:225 → 266

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
NM_014868.5 → NP_055683.3 E3 ubiquitin-protein ligase RNF10 isoform 1

See identical proteins and their annotated locations for NP_055683.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

BC016622, BQ015862, DA103961, DB526099

Consensus CDS

CCDS9201.1

UniProtKB/Swiss-Prot

Q8N5U6, Q92550, Q9NPP8, Q9ULW4

UniProtKB/TrEMBL

A0A024RBP0, B3KSN5, B3KUR9

Related

ENSP00000322242.4, ENST00000325954.9

Conserved Domains (1) summary

cd16536
Location:225 → 267

RING-HC_RNF10; RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins