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    ZNF746 zinc finger protein 746 [ Homo sapiens (human) ]

    Gene ID: 155061, updated on 10-Jun-2024

    Summary

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    Official Symbol
    ZNF746provided by HGNC
    Official Full Name
    zinc finger protein 746provided by HGNC
    Primary source
    HGNC:HGNC:21948
    See related
    Ensembl:ENSG00000181220 MIM:613914; AllianceGenome:HGNC:21948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARIS
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF746 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149472696..149497809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150654556..150679673, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149169787..149194900, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene zinc finger protein 777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1 Neighboring gene tRNA-Cys (anticodon GCA) 22-1 Neighboring gene zinc finger family member 767, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population. Li CY, et al. Mol Neurobiol, 2021 Jul. PMID 33723766
    2. PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy. Mukherjee D, et al. Mol Cell Biol, 2020 Dec 21. PMID 33077496, Free PMC Article
    3. Inhibition of ZNF746 suppresses invasion and epithelial to mesenchymal transition in H460 non-small cell lung cancer cells. Kim B, et al. Oncol Rep, 2014 Jan. PMID 24145959
    4. SUMO-specific protease SENP3 enhances MDM2-mediated ubiquitination of PARIS/ZNF746 in HeLa cells. Nishida T. Biochem Biophys Res Commun, 2022 Jul 30. PMID 35623300
    5. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma. Kim H, et al. Biochem Biophys Res Commun, 2021 Jul 23. PMID 34062393

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting.
      Title: Unveiling the regulatory of miR-101-3p on ZNF746 in a Parkinson's disease cell model: Implications for therapeutic targeting.
    2. PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
      Title: PARIS undergoes liquid-liquid phase separation and poly(ADP-ribose)-mediated solidification.
    3. ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway.
      Title: ZNF746 promotes M2 macrophage polarisation and favours tumour progression in breast cancer via the Jagged1/Notch pathway.
    4. Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population.
      Title: Genetic Analysis of ZNF Protein Family Members for Early-Onset Parkinson's Disease in Chinese Population.
    5. ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
      Title: ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.
    6. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
      Title: PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.
    7. PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
      Title: PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
    8. RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
      Title: RNF4-mediated SUMO-targeted ubiquitination relieves PARIS/ZNF746-mediated transcriptional repression.
    9. We show that parkin is inactivated leading to the accumulation of parkin interacting substrate protein (PARIS) (zinc finger protein 746) (ZNF746) in 3 models of Parkinson's disease
      Title: Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.
    10. the findings suggest that ZNF746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3beta and F-box/WD repeat-containing protein 7.
      Title: Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31413

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 746
    Names
    parkin-interacting substrate
    parkin-interacting sustrate

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163474.2 → NP_001156946.1  zinc finger protein 746 isoform 1

      See identical proteins and their annotated locations for NP_001156946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004932, AI991498, AK291814, BC068505
      Consensus CDS
      CCDS55180.1
      UniProtKB/Swiss-Prot
      Q6NUN9
      Related
      ENSP00000508891.1, ENST00000685153.1
      Conserved Domains (6) summary
      cd07765
      Location:106 → 135
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:106 → 156
      KRAB; krueppel associated box
      COG5048
      Location:512 → 589
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:513 → 533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:567 → 589
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:525 → 549
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001363517.2 → NP_001350446.1  zinc finger protein 746 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004932, AC073314
      Consensus CDS
      CCDS87562.1
      UniProtKB/TrEMBL
      A0A2R8YDQ5
      Related
      ENSP00000493970.1, ENST00000644635.1
      Conserved Domains (4) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      COG5048
      Location:526 → 603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527 → 547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001394198.1 → NP_001381127.1  zinc finger protein 746 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC004932, AC073314
      Consensus CDS
      CCDS94227.1
      UniProtKB/TrEMBL
      A0A8J9FQ52
      Related
      ENSP00000395007.3, ENST00000458143.7
      Conserved Domains (6) summary
      smart00349
      Location:111 → 171
      KRAB; krueppel associated box
      sd00017
      Location:528 → 548
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:582 → 604
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:25 → 81
      DUF3669; Zinc finger protein
      pfam13465
      Location:569 → 593
      zf-H2C2_2; Zinc-finger double domain
      pfam16622
      Location:522 → 548
      zf-C2H2_11; zinc-finger C2H2-type

    4. NM_152557.5 → NP_689770.3  zinc finger protein 746 isoform 2

      See identical proteins and their annotated locations for NP_689770.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks one residue near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004932, AC073314, AI991498, BC068505, BM512385
      Consensus CDS
      CCDS5897.1
      UniProtKB/Swiss-Prot
      A8K6Z9, Q6NUN9, Q6ZRF9
      Related
      ENSP00000345140.3, ENST00000340622.8
      Conserved Domains (6) summary
      cd07765
      Location:106 → 135
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:106 → 156
      KRAB; krueppel associated box
      COG5048
      Location:511 → 588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:512 → 532
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:566 → 588
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:524 → 548
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149472696..149497809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419925.1 → XP_047275881.1  zinc finger protein 746 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150654556..150679673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357354.1 → XP_054213329.1  zinc finger protein 746 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NUN9.1 GenPept UniProtKB/Swiss-Prot:Q6NUN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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