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    CIP2A cellular inhibitor of PP2A [ Homo sapiens (human) ]

    Gene ID: 57650, updated on 11-Apr-2024

    Summary

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    Official Symbol
    CIP2Aprovided by HGNC
    Official Full Name
    cellular inhibitor of PP2Aprovided by HGNC
    Primary source
    HGNC:HGNC:29302
    See related
    Ensembl:ENSG00000163507 MIM:610643; AllianceGenome:HGNC:29302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p90; NOCIVA; KIAA1524
    Summary
    Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    3q13.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108549864..108589438, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111258902..111309711, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268711..108308285, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene uncharacterized LOC124909406 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma. Szudy-Szczyrek A, et al. Cells, 2023 Mar 28. PMID 37048102, Free PMC Article
    2. Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer. Chen D, et al. Mol Carcinog, 2023 Apr. PMID 36705466
    3. Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease? Yin S, et al. Mol Neurobiol, 2022 Feb. PMID 34984583, Free PMC Article
    4. Integrative assessment of CIP2A overexpression and mutational effects in human malignancies identifies possible deleterious variants. Tarek MM, et al. Comput Biol Med, 2021 Dec. PMID 34739970
    5. Depletion of CIP2A inhibits the proliferation, migration, invasion and epithelial-mesenchymal transition of glioma cells. Xu Z, et al. Brain Res Bull, 2021 Aug. PMID 33892085

    See all (204) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response.
      Title: CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response.
    2. Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition.
      Title: Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition.
    3. The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.
      Title: The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma.
    4. Structural mechanism for inhibition of PP2A-B56alpha and oncogenicity by CIP2A.
      Title: Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
    5. Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer.
      Title: Cip2a induces arginine biosynthesis and promotes tumor progression in non-small cell lung cancer.
    6. m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
      Title: m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability.
    7. The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
      Title: The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
    8. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
      Title: Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
    9. Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
      Title: Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Could It Be a Promising Biomarker and Therapeutic Target in Parkinson's Disease?
    10. Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.
      Title: Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias.
    Submit: New GeneRIF Correction See all GeneRIFs (133)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ12850, MGC163436

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in broken chromosome clustering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    protein CIP2A
    Names
    cancerous inhibitor of PP2A
    cancerous inhibitor of protein phosphatase 2A
    cell proliferation regulating inhibitor of protein phosphatase 2A
    p90 autoantigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020890.3 → NP_065941.2  protein CIP2A

      See identical proteins and their annotated locations for NP_065941.2

      Status: VALIDATED

      Source sequence(s)
      AC069499, AK310446, BC017659, BC130564
      Consensus CDS
      CCDS33812.1
      UniProtKB/Swiss-Prot
      A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
      Related
      ENSP00000295746.7, ENST00000295746.13
      Conserved Domains (1) summary
      cl25732
      Location:618 → 868
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      108549864..108589438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713716.4 → XP_006713779.1  protein CIP2A isoform X1

      Conserved Domains (3) summary
      pfam15272
      Location:727 → 867
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17045
      Location:632 → 877
      CEP63; Centrosomal protein of 63 kDa
      cl23720
      Location:805 → 890
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_011513057.3 → XP_011511359.1  protein CIP2A isoform X2

      Conserved Domains (2) summary
      pfam15272
      Location:414 → 554
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17045
      Location:319 → 564
      CEP63; Centrosomal protein of 63 kDa

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      111258902..111309711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347406.1 → XP_054203381.1  protein CIP2A isoform X3

      UniProtKB/Swiss-Prot
      A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204

    2. XM_054347407.1 → XP_054203382.1  protein CIP2A isoform X1

    3. XM_054347408.1 → XP_054203383.1  protein CIP2A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCG1.2 GenPept UniProtKB/Swiss-Prot:Q8TCG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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