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    Tmprss11c transmembrane protease, serine 11c [ Mus musculus (house mouse) ]

    Gene ID: 435845, updated on 12-May-2024

    Summary

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    Official Symbol
    Tmprss11cprovided by MGI
    Official Full Name
    transmembrane protease, serine 11cprovided by MGI
    Primary source
    MGI:MGI:3521861
    See related
    Ensembl:ENSMUSG00000061184 AllianceGenome:MGI:3521861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmprss13
    Summary
    Enables serine-type endopeptidase activity. Involved in self proteolysis. Located in dendrite and perikaryon. Is integral component of plasma membrane. Orthologous to human TMPRSS11CP (transmembrane serine protease 11C, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    5 E1; 5 43.56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86376600..86437167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86231481..86289308, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene STARR-seq mESC enhancer starr_13545 Neighboring gene predicted gene, 25473 Neighboring gene transmembrane protease, serine 11d Neighboring gene STARR-seq mESC enhancer starr_13546 Neighboring gene STARR-seq mESC enhancer starr_13547 Neighboring gene STARR-seq mESC enhancer starr_13548 Neighboring gene predicted gene, 35367 Neighboring gene STARR-seq mESC enhancer starr_13549 Neighboring gene transmembrane protease, serine 11a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2 in vitro. Stallmach R, et al. Biochem J, 2008 May 15. PMID 18215125
    2. Iterative, multiplexed CRISPR-mediated gene editing for functional analysis of complex protease gene clusters. Callies LK, et al. J Biol Chem, 2019 Nov 1. PMID 31501243, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurobin is an authentic transmembrane serine protease with trypsin-like activity and is able to process FGF-2 in vitro.
      Title: Neurobin/TMPRSS11c, a novel type II transmembrane serine protease that cleaves fibroblast growth factor-2 in vitro.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in self proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protease serine 11C
    Names
    neurobin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030297.3 → NP_001025468.1  transmembrane protease serine 11C

      See identical proteins and their annotated locations for NP_001025468.1

      Status: VALIDATED

      Source sequence(s)
      AC100746
      Consensus CDS
      CCDS19380.1
      UniProtKB/Swiss-Prot
      Q1JRP2
      UniProtKB/TrEMBL
      A0A0G2JET7
      Related
      ENSMUSP00000062915.6, ENSMUST00000059424.10
      Conserved Domains (3) summary
      smart00020
      Location:199 → 425
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:200 → 428
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:62 → 157
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      86376600..86437167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1JRP2.1 GenPept UniProtKB/Swiss-Prot:Q1JRP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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