Cntnap5c contactin associated protein-like 5C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cntnap5cprovided by MGI
Official Full Name: contactin associated protein-like 5Cprovided by MGI
Primary source: MGI:MGI:3646013
See related: Ensembl:ENSMUSG00000038048 AllianceGenome:MGI:3646013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm325; Caspr5-3; EG620292
Summary: Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in CA1 pyramidal cell layer; brain; central nervous system; and hippocampus CA3. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 1.3), frontal lobe adult (RPKM 0.7) and 6 other tissues See more
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Genomic context

Location:: 17 D; 17 30.01 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (58076070..58724948)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (57769074..58417953)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the three Caspr5 genes are located on chromosomes 1 & 17; all three paralogs are expressed; common expression is found in brain tissue but different expression patterns are seen in other organs during fetal development and & in the adult stage
Title: New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

G67050 (e-PCR)
- UniSTS:178259

MHAa29c6.seq (e-PCR)
- UniSTS:125120

D17Mit109 (e-PCR), detects polymorphism
- UniSTS:116479

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: contactin-associated protein like 5-3

Names: cell recognition molecule Caspr5-3; cell recognition molecule Caspr5c; contactin-associated protein-like 5c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081653.3 → NP_001075122.1 contactin-associated protein like 5-3 precursor

See identical proteins and their annotated locations for NP_001075122.1

Status: VALIDATED

Source sequence(s)

AC118684, AC120548, AC122209, AC127557, AC154498, CT025736

Consensus CDS

CCDS37671.1

UniProtKB/Swiss-Prot

Q0V8T7

Related

ENSMUSP00000075416.6, ENSMUST00000076038.7

Conserved Domains (6) summary

smart00231
Location:30 → 174

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:960 → 995

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:792 → 936

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:395 → 521

Laminin_G_2; Laminin G domain

RNA

NR_160889.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC120548

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

58076070..58724948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524744.3 → XP_006524807.1 contactin-associated protein like 5-3 isoform X5

See identical proteins and their annotated locations for XP_006524807.1

Conserved Domains (6) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:961 → 996

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 937

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524747.4 → XP_006524810.1 contactin-associated protein like 5-3 isoform X6

Conserved Domains (6) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:961 → 996

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 937

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524750.4 → XP_006524813.1 contactin-associated protein like 5-3 isoform X10

Conserved Domains (4) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524748.4 → XP_006524811.1 contactin-associated protein like 5-3 isoform X7

Conserved Domains (5) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 890

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524749.4 → XP_006524812.1 contactin-associated protein like 5-3 isoform X9

Conserved Domains (4) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524741.4 → XP_006524804.1 contactin-associated protein like 5-3 isoform X1

Conserved Domains (6) summary

smart00282
Location:205 → 338

LamG; Laminin G domain

cd00054
Location:961 → 996

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:793 → 937

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:551 → 582

EGF; EGF-like domain

pfam02210
Location:396 → 519

Laminin_G_2; Laminin G domain
XM_006524742.5 → XP_006524805.1 contactin-associated protein like 5-3 isoform X2

Conserved Domains (5) summary

cd00054
Location:913 → 948

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:39 → 173

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:745 → 889

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:503 → 534

EGF; EGF-like domain

pfam02210
Location:348 → 471

Laminin_G_2; Laminin G domain
XM_030249937.2 → XP_030105797.1 contactin-associated protein like 5-3 isoform X4

Conserved Domains (6) summary

smart00282
Location:73 → 206

LamG; Laminin G domain

cd00054
Location:829 → 864

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:661 → 805

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cl25480
Location:2 → 42

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:419 → 450

EGF; EGF-like domain

pfam02210
Location:264 → 387

Laminin_G_2; Laminin G domain
XM_036160717.1 → XP_036016610.1 contactin-associated protein like 5-3 isoform X8

Conserved Domains (4) summary

cd00054
Location:512 → 547

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:344 → 488

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:102 → 133

EGF; EGF-like domain

pfam02210
Location:596 → 724

Laminin_G_2; Laminin G domain
XM_017317594.3 → XP_017173083.1 contactin-associated protein like 5-3 isoform X11

Conserved Domains (3) summary

cd00054
Location:331 → 366

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:163 → 307

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam02210
Location:415 → 540

Laminin_G_2; Laminin G domain
XM_011246557.4 → XP_011244859.1 contactin-associated protein like 5-3 isoform X3

Conserved Domains (6) summary

smart00282
Location:144 → 277

LamG; Laminin G domain

cd00054
Location:900 → 935

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:2 → 112

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd00110
Location:732 → 876

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:490 → 521

EGF; EGF-like domain

pfam02210
Location:335 → 458

Laminin_G_2; Laminin G domain