PHB1 prohibitin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PHB1provided by HGNC
Official Full Name: prohibitin 1provided by HGNC
Primary source: HGNC:HGNC:8912
See related: Ensembl:ENSG00000167085 MIM:176705; AllianceGenome:HGNC:8912
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PHB; HEL-215; HEL-S-54e
Summary: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Ubiquitous expression in kidney (RPKM 68.3), colon (RPKM 44.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (49404052..49414882, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (50267083..50277908, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (47481414..47492244, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Title: PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids.
Title: Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids.
Hepatic prohibitin 1 and methionine adenosyltransferase alpha1 defend against primary and secondary liver cancer metastasis.
Title: Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis.
Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells.
Title: Prohibitin Links Cell Cycle, Motility and Invasion in Prostate Cancer Cells.
The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor.
Title: The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor.
XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.
Title: XIAP and PHB1 Regulate Anoikis through Competitive Binding to TRAF6.
Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis.
Title: Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis.
Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
Title: Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility.
Prohibitin regulates mTOR pathway via interaction with FKBP8.
Title: Prohibitin regulates mTOR pathway via interaction with FKBP8.
Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.
Title: Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance.

Submit: New GeneRIF Correction See all GeneRIFs (146)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
	env	HIV-1 gp120 upregulates the expression of prohibitin in umbilical cord blood mononuclear cells and T-cell lines	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 is identified to have a physical interaction with prohibitin 1 (PHB1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
	env	The C-terminal cytoplasmic domain (Env-CT) of HIV-1 Env specifically binds to the Phb1/Phb2 complex. Strong binding is dependent on Env residues 790-800. L799R/L800Q double mutation in Env severely inhibits its binding to the Phb1/Phb2 complex	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 is identified to have a physical interaction with prohibitin (PHB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Tandem affinity purification and mass spectrometry analysis identify prohibitin (PHB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of prohibitin (PHB) in the nucleoli of Jurkat T-cells	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of prohibitin (PHB) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed
	vpr	The proteomic assay from Vpr-expressing HTLV-1 transformed cells reveals apoptosis related protein changes, such as mitochondrial protein prohibitin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S895E (e-PCR)
- UniSTS:473118

RH127963 (e-PCR)
- UniSTS:211273

RH91824 (e-PCR)
- UniSTS:90954

RH11580 (e-PCR)
- UniSTS:66457

SHGC-32028 (e-PCR)
- UniSTS:54746

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables complement component C3a binding	IDA Inferred from Direct Assay more info	PubMed
enables complement component C3b binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables proteinase activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in CD40 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in T-helper 17 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of phospholipase C activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of protein kinase C activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-6	IDA Inferred from Direct Assay more info	PubMed
involved_in epigenetic regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	NAS Non-traceable Author Statement more info	PubMed
involved_in modulation by host of viral RNA genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucocorticoid receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by competitive promoter binding	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	HDA more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of immunoglobulin production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in progesterone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in symbiont entry into host cell	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info	PubMed
part_of mitochondrial prohibitin complex	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial prohibitin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prohibitin 1

Names: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; prohibitin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023046.2 RefSeqGene

Range

5000..15830

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001281496.2 → NP_001268425.1 prohibitin 1 isoform 1

See identical proteins and their annotated locations for NP_001268425.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AC091180

Consensus CDS

CCDS11548.1

UniProtKB/Swiss-Prot

B4DY47, P35232, Q4VBQ0

UniProtKB/TrEMBL

A8K401, Q53FV0, Q6PUJ7

Related

ENSP00000484113.1, ENST00000617874.5

Conserved Domains (1) summary

cd03401
Location:27 → 221

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001281497.2 → NP_001268426.1 prohibitin 1 isoform 2

See identical proteins and their annotated locations for NP_001268426.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses alternate in-frame splice sites and lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AC091180

Consensus CDS

CCDS62244.1

UniProtKB/Swiss-Prot

P35232

Related

ENSP00000512581.1, ENST00000696365.1

Conserved Domains (1) summary

cd03401
Location:27 → 141

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001281715.2 → NP_001268644.1 prohibitin 1 isoform 1

See identical proteins and their annotated locations for NP_001268644.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AC091180

Consensus CDS

CCDS11548.1

UniProtKB/Swiss-Prot

B4DY47, P35232, Q4VBQ0

UniProtKB/TrEMBL

A8K401, Q53FV0, Q6PUJ7

Related

ENSP00000479488.1, ENST00000614445.5

Conserved Domains (1) summary

cd03401
Location:27 → 221

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_002634.4 → NP_002625.1 prohibitin 1 isoform 1

See identical proteins and their annotated locations for NP_002625.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AC091180

Consensus CDS

CCDS11548.1

UniProtKB/Swiss-Prot

B4DY47, P35232, Q4VBQ0

UniProtKB/TrEMBL

A8K401, Q53FV0, Q6PUJ7

Related

ENSP00000300408.3, ENST00000300408.8

Conserved Domains (1) summary

cd03401
Location:27 → 221

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

49404052..49414882 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017024763.2 → XP_016880252.1 prohibitin 1 isoform X1

UniProtKB/Swiss-Prot

B4DY47, P35232, Q4VBQ0

UniProtKB/TrEMBL

A8K401, Q53FV0, Q6PUJ7

Conserved Domains (1) summary

cd03401
Location:27 → 221

SPFH_prohibitin; Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily