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    ZNF333 zinc finger protein 333 [ Homo sapiens (human) ]

    Gene ID: 84449, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF333provided by HGNC
    Official Full Name
    zinc finger protein 333provided by HGNC
    Primary source
    HGNC:HGNC:15624
    See related
    Ensembl:ENSG00000160961 MIM:611811; AllianceGenome:HGNC:15624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in appendix (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    19p13.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14689787..14733742)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14816091..14860049)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14800860..14844554)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10261 Neighboring gene adhesion G protein-coupled receptor E3 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:14910875-14912074 Neighboring gene olfactory receptor family 7 subfamily C member 1 Neighboring gene olfactory receptor family 7 subfamily A member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of the DNA binding element of the human ZNF333 protein. Jing Z, et al. J Biochem Mol Biol, 2004 Nov 30. PMID 15607024
    2. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. Tian Y, et al. Biochim Biophys Acta, 2002 Aug 19. PMID 12151103
    3. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. Oh Y, et al. Cell Mol Biol Lett, 2007. PMID 17607528, Free PMC Article
    4. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF333 recognized the specific DNA core binding sequence ATAAT
      Title: Identification of the DNA binding element of the human ZNF333 protein.
    2. dna sequence analysis of ZNF333 gene located on chromosome 19p13.1
      Title: Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 333 (ZNF333) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1806

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 333

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300912.2 → NP_001287841.1  zinc finger protein 333 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090427, AF372702, BC048107, DA103403
      Consensus CDS
      CCDS74298.1
      UniProtKB/Swiss-Prot
      Q96JL9
      Related
      ENSP00000438130.1, ENST00000540689.6
      Conserved Domains (2) summary
      smart00349
      Location:203 → 263
      KRAB; krueppel associated box
      pfam01352
      Location:203 → 242
      KRAB; KRAB box

    2. NM_001352239.2 → NP_001339168.1  zinc finger protein 333 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, BP231733, DA103403, HY032449
      UniProtKB/TrEMBL
      B3KSN8
      Conserved Domains (5) summary
      smart00349
      Location:94 → 154
      KRAB; krueppel associated box
      COG5048
      Location:119 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315 → 335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:509 → 531
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440 → 463
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001352240.2 → NP_001339169.1  zinc finger protein 333 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, BP231733, DA103403, DC335178, HY032449
      UniProtKB/TrEMBL
      B3KSN8
      Conserved Domains (5) summary
      smart00349
      Location:94 → 154
      KRAB; krueppel associated box
      COG5048
      Location:119 → 416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:315 → 335
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:509 → 531
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:440 → 463
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001352241.2 → NP_001339170.1  zinc finger protein 333 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403, DA248936
      Conserved Domains (4) summary
      smart00349
      Location:57 → 117
      KRAB; krueppel associated box
      COG5048
      Location:211 → 379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:278 → 298
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:403 → 426
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001352243.2 → NP_001339172.1  zinc finger protein 333 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403
      Conserved Domains (4) summary
      COG5048
      Location:126 → 294
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:193 → 213
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:318 → 341
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. NM_001352244.2 → NP_001339173.1  zinc finger protein 333 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090427, AF372702, DA103403
      Conserved Domains (1) summary
      smart00349
      Location:203 → 263
      KRAB; krueppel associated box

    7. NM_032433.4 → NP_115809.1  zinc finger protein 333 isoform 1

      See identical proteins and their annotated locations for NP_115809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090427, AF372702, DA103403
      Consensus CDS
      CCDS12316.1
      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
      Related
      ENSP00000292530.5, ENST00000292530.11
      Conserved Domains (6) summary
      smart00349
      Location:203 → 263
      KRAB; krueppel associated box
      COG5048
      Location:228 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394 → 416
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:203 → 242
      KRAB; KRAB box
      pfam13465
      Location:408 → 433
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14689787..14733742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528362.3 → XP_011526664.1  zinc finger protein 333 isoform X1

      See identical proteins and their annotated locations for XP_011526664.1

      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9
      Conserved Domains (6) summary
      smart00349
      Location:203 → 263
      KRAB; krueppel associated box
      COG5048
      Location:228 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:394 → 416
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:203 → 242
      KRAB; KRAB box
      pfam13465
      Location:408 → 433
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047439519.1 → XP_047295475.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8

    3. XM_047439518.1 → XP_047295474.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8

    4. XM_011528371.3 → XP_011526673.1  zinc finger protein 333 isoform X3

      Conserved Domains (6) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:168 → 336
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:235 → 255
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:205 → 227
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:219 → 244
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14816091..14860049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322348.1 → XP_054178323.1  zinc finger protein 333 isoform X1

      UniProtKB/Swiss-Prot
      Q6P2E6, Q86WS6, Q8TDL0, Q96JL9

    2. XM_054322349.1 → XP_054178324.1  zinc finger protein 333 isoform X2

      UniProtKB/TrEMBL
      B3KSN8

    3. XM_054322350.1 → XP_054178325.1  zinc finger protein 333 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JL9.3 GenPept UniProtKB/Swiss-Prot:Q96JL9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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