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    Tbcel tubulin folding cofactor E-like [ Mus musculus (house mouse) ]

    Gene ID: 272589, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tbcelprovided by MGI
    Official Full Name
    tubulin folding cofactor E-likeprovided by MGI
    Primary source
    MGI:MGI:1925543
    See related
    Ensembl:ENSMUSG00000037287 AllianceGenome:MGI:1925543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrrc35; D330014K23; E130107N23Rik
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 10.3), liver E14 (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbcel in Genome Data Viewer
    Location:
    9 A5.1; 9 23.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (42323612..42383534, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (42412316..42472238, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26272 Neighboring gene tectorin alpha Neighboring gene STARR-seq mESC enhancer starr_23902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:42236216-42236386 Neighboring gene predicted gene, 47629 Neighboring gene STARR-seq mESC enhancer starr_23903 Neighboring gene STARR-seq mESC enhancer starr_23904 Neighboring gene STARR-positive B cell enhancer ABC_E9327 Neighboring gene predicted gene 16322 Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590 Neighboring gene STARR-seq mESC enhancer starr_23909 Neighboring gene STARR-seq mESC enhancer starr_23910 Neighboring gene STARR-seq mESC enhancer starr_23911 Neighboring gene predicted gene, 36648

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone cofactor E-like protein
    Names
    leucine-rich repeat-containing protein 35

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357656.3 → NP_001344585.2  tubulin-specific chaperone cofactor E-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC136903, AC156631
      Consensus CDS
      CCDS90542.1
      UniProtKB/Swiss-Prot
      B9EID8, Q8C5W3, Q8C7A5
      Related
      ENSMUSP00000065125.8, ENSMUST00000066179.14
      Conserved Domains (5) summary
      sd00031
      Location:78 → 101
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:129 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:337 → 422
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:191 → 304
      LRR_9; Leucine-rich repeat
      cd21340
      Location:50 → 113
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. NM_001357657.3 → NP_001344586.1  tubulin-specific chaperone cofactor E-like protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC136903, AC156631
      Consensus CDS
      CCDS23088.1
      UniProtKB/Swiss-Prot
      B9EID8, Q8C5W3, Q8C7A5
      Related
      ENSMUSP00000114721.2, ENSMUST00000125995.8
      Conserved Domains (5) summary
      sd00031
      Location:78 → 101
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:129 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:337 → 422
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:191 → 304
      LRR_9; Leucine-rich repeat
      cd21340
      Location:50 → 113
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. NM_001378604.1 → NP_001365533.1  tubulin-specific chaperone cofactor E-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC136903, AC156631
      Conserved Domains (3) summary
      sd00033
      Location:51 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:212 → 297
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:66 → 179
      LRR_9; Leucine-rich repeat

    4. NM_173038.5 → NP_766626.1  tubulin-specific chaperone cofactor E-like protein isoform b

      See identical proteins and their annotated locations for NP_766626.1

      Status: VALIDATED

      Source sequence(s)
      AC136903, AC156631
      Consensus CDS
      CCDS23088.1
      UniProtKB/Swiss-Prot
      B9EID8, Q8C5W3, Q8C7A5
      Related
      ENSMUSP00000067882.6, ENSMUST00000066148.12
      Conserved Domains (5) summary
      sd00031
      Location:78 → 101
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:129 → 148
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:337 → 422
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:191 → 304
      LRR_9; Leucine-rich repeat
      cd21340
      Location:50 → 113
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      42323612..42383534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510396.5 → XP_006510459.1  tubulin-specific chaperone cofactor E-like protein isoform X1

      See identical proteins and their annotated locations for XP_006510459.1

      Conserved Domains (3) summary
      sd00033
      Location:51 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      cd17045
      Location:212 → 297
      Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
      pfam14580
      Location:66 → 179
      LRR_9; Leucine-rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5W3.1 GenPept UniProtKB/Swiss-Prot:Q8C5W3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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