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    ZNF789 zinc finger protein 789 [ Homo sapiens (human) ]

    Gene ID: 285989, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ZNF789provided by HGNC
    Official Full Name
    zinc finger protein 789provided by HGNC
    Primary source
    HGNC:HGNC:27801
    See related
    Ensembl:ENSG00000198556 AllianceGenome:HGNC:27801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 3.7), testis (RPKM 2.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    7q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99472890..99487605)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100711703..100726513)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99070513..99085228)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99058948-99059448 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99062959-99063576 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99063577-99064192 Neighboring gene ATP synthase membrane subunit f Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26319 Neighboring gene tRNA-Trp (anticodon CCA) 5-1 Neighboring gene zinc finger protein 394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99096344-99097012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26323 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99106467-99106660 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome. Bradic M, et al. J Transl Med, 2022 Nov 12. PMID 36371196, Free PMC Article
    2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
    3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 789

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013258.2 → NP_001013276.1  zinc finger protein 789 isoform 2

      See identical proteins and their annotated locations for NP_001013276.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC073063, AK093141, BC031249, BM840763
      Consensus CDS
      CCDS34694.1
      UniProtKB/TrEMBL
      F8WEN0
      Related
      ENSP00000369047.3, ENST00000379724.3
      Conserved Domains (1) summary
      pfam01352
      Location:10 → 50
      KRAB; KRAB box

    2. NM_001350999.2 → NP_001337928.1  zinc finger protein 789 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC073063
      Conserved Domains (3) summary
      smart00349
      Location:1 → 54
      KRAB; krueppel associated box
      COG5048
      Location:236 → 296
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001351000.2 → NP_001337929.1  zinc finger protein 789 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC073063
      Conserved Domains (3) summary
      COG5048
      Location:215 → 275
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:221 → 241
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:10 → 51
      KRAB; KRAB box

    4. NM_001351001.2 → NP_001337930.1  zinc finger protein 789 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC073063
      UniProtKB/TrEMBL
      C9J3R7
      Conserved Domains (1) summary
      pfam01352
      Location:10 → 51
      KRAB; KRAB box

    5. NM_001351002.2 → NP_001337931.1  zinc finger protein 789 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
      Source sequence(s)
      AC073063
      Conserved Domains (2) summary
      COG5048
      Location:158 → 218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001351004.2 → NP_001337933.1  zinc finger protein 789 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
      Source sequence(s)
      AC073063, AK309467
      Conserved Domains (2) summary
      COG5048
      Location:158 → 218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_213603.3 → NP_998768.2  zinc finger protein 789 isoform 1

      See identical proteins and their annotated locations for NP_998768.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC073063, AK093141, BC089424, BI767175
      Consensus CDS
      CCDS34693.1
      UniProtKB/Swiss-Prot
      A4D282, A6NH61, Q5FWF6, Q6ZMZ9
      Related
      ENSP00000331927.5, ENST00000331410.10
      Conserved Domains (5) summary
      smart00349
      Location:11 → 71
      KRAB; krueppel associated box
      COG5048
      Location:283 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:11 → 50
      KRAB; KRAB box
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_147001.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073063

    2. NR_147002.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073063, BC031249, CB140921

    3. NR_147003.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC073063, AK309467, BC031249
      Related
      ENST00000483089.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      99472890..99487605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420230.1 → XP_047276186.1  zinc finger protein 789 isoform X4

    2. XM_024446725.2 → XP_024302493.1  zinc finger protein 789 isoform X4

      Conserved Domains (2) summary
      COG5048
      Location:158 → 218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047420229.1 → XP_047276185.1  zinc finger protein 789 isoform X3

    4. XM_017012022.2 → XP_016867511.1  zinc finger protein 789 isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:236 → 296
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242 → 262
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047420226.1 → XP_047276182.1  zinc finger protein 789 isoform X2

    6. XM_047420227.1 → XP_047276183.1  zinc finger protein 789 isoform X2

    7. XM_017012018.2 → XP_016867507.1  zinc finger protein 789 isoform X1

      UniProtKB/Swiss-Prot
      A4D282, A6NH61, Q5FWF6, Q6ZMZ9
      Conserved Domains (5) summary
      smart00349
      Location:11 → 71
      KRAB; krueppel associated box
      COG5048
      Location:283 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:11 → 50
      KRAB; KRAB box
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    8. XM_047420231.1 → XP_047276187.1  zinc finger protein 789 isoform X5

    9. XM_047420228.1 → XP_047276184.1  zinc finger protein 789 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      100711703..100726513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357940.1 → XP_054213915.1  zinc finger protein 789 isoform X1

      UniProtKB/Swiss-Prot
      A4D282, A6NH61, Q5FWF6, Q6ZMZ9

    2. XM_054357947.1 → XP_054213922.1  zinc finger protein 789 isoform X5

    3. XM_054357945.1 → XP_054213920.1  zinc finger protein 789 isoform X4

    4. XM_054357943.1 → XP_054213918.1  zinc finger protein 789 isoform X3

    5. XM_054357944.1 → XP_054213919.1  zinc finger protein 789 isoform X3

    6. XM_054357941.1 → XP_054213916.1  zinc finger protein 789 isoform X2

    7. XM_054357946.1 → XP_054213921.1  zinc finger protein 789 isoform X4

    8. XM_054357942.1 → XP_054213917.1  zinc finger protein 789 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWF6.3 GenPept UniProtKB/Swiss-Prot:Q5FWF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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