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    Pla2r1 phospholipase A2 receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295631, updated on 31-Mar-2024

    Summary

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    Symbol
    Pla2r1provided by RGD
    Full Name
    phospholipase A2 receptor 1provided by RGD
    Primary source
    RGD:1309777
    See related
    Ensembl:ENSRNOG00000008129 AllianceGenome:RGD:1309777
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase binding activity and signaling receptor activity. Predicted to be involved in several processes, including negative regulation of phospholipase A2 activity; oxidative stress-induced premature senescence; and regulation of arachidonic acid secretion. Predicted to be located in cell surface and extracellular region. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLA2R1 (phospholipase A2 receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 24.8), Adrenal (RPKM 22.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla2r1 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (65292629..65422462, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (44883943..45013793, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (46488963..46621873, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101907 Neighboring gene microRNA 6216 Neighboring gene lymphocyte antigen 75 Neighboring gene integrin subunit beta 6 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC108350379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. Granata F, et al. J Immunol, 2005 Jan 1. PMID 15611272
    2. Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Silliman CC, et al. Am J Physiol Cell Physiol, 2002 Oct. PMID 12225974
    3. The M-type receptor PLA2R regulates senescence through the p53 pathway. Augert A, et al. EMBO Rep, 2009 Mar. PMID 19197340, Free PMC Article
    4. sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor. Pan Y, et al. Sci Rep, 2014 Oct 22. PMID 25335547, Free PMC Article
    5. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. Fonteh AN, et al. J Immunol, 2000 Sep 1. PMID 10946309

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
      Title: Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxidative stress-induced premature senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of arachidonic acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of arachidonic acid secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of podocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replicative senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replicative senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    secretory phospholipase A2 receptor
    Names
    secretory phospholipase A2 receptor-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100837.1 → NP_001094307.1  secretory phospholipase A2 receptor precursor

      See identical proteins and their annotated locations for NP_001094307.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A6JF83, F1M495
      Related
      ENSRNOP00000011003.6, ENSRNOT00000011003.7
      Conserved Domains (4) summary
      smart00034
      Location:378 → 502
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:46 → 143
      RICIN; Ricin-type beta-trefoil
      cd00062
      Location:173 → 220
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      cd00161
      Location:54 → 133
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      65292629..65422462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104479.2 → XP_038960407.1  secretory phospholipase A2 receptor isoform X1

      Conserved Domains (1) summary
      smart00034
      Location:146 → 270
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

    2. XM_039104480.2 → XP_038960408.1  secretory phospholipase A2 receptor isoform X2

      Conserved Domains (3) summary
      smart00034
      Location:378 → 502
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      smart00458
      Location:46 → 143
      RICIN; Ricin-type beta-trefoil
      cd00062
      Location:173 → 220
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    Nucleotide Protein Strain
    Heading Accession and Version

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