WWP1 WW domain containing E3 ubiquitin protein ligase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WWP1provided by HGNC
Official Full Name: WW domain containing E3 ubiquitin protein ligase 1provided by HGNC
Primary source: HGNC:HGNC:17004
See related: Ensembl:ENSG00000123124 MIM:602307; AllianceGenome:HGNC:17004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIP5; Tiul1; hSDRP1
Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in liver (RPKM 24.3), gall bladder (RPKM 23.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q21.3

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (86342547..86468503)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (87462833..87588744)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (87354776..87480732)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer.
Title: High Expression of WWP1 Associates with Tumor Progression in Papillary Thyroid Cancer.
alpha-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer.
Title: α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer.
WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis.
Title: WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis.
miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/beta-catenin signaling pathway.
Title: miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway.
AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
Title: AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
Title: WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
Title: Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy.
Title: Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy.
CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.
Title: CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway.
BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression.
Title: BAP1 antagonizes WWP1-mediated transcription factor KLF5 ubiquitination and inhibits autophagy to promote melanoma progression.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77138 (e-PCR)
- UniSTS:15772

RH17838 (e-PCR)
- UniSTS:82090

RH124031 (e-PCR)
- UniSTS:134571

SGC38286 (e-PCR)
- UniSTS:22232

SHGC-58053 (e-PCR)
- UniSTS:20957

STS-H20821 (e-PCR)
- UniSTS:2800

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in monoatomic ion transmembrane transport	TAS Traceable Author Statement more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in symbiont entry into host cell	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: NEDD4-like E3 ubiquitin-protein ligase WWP1

Names: HECT-type E3 ubiquitin transferase WWP1; Nedd-4-like ubiquitin-protein ligase; TGIF-interacting ubiquitin ligase 1; WW domain-containing protein 1; atrophin-1 interacting protein 5

NP_008944.1

EC 2.3.2.26

XP_005250817.1

EC 2.3.2.26

XP_005250818.1

EC 2.3.2.26

XP_016868482.1

EC 2.3.2.26

XP_016868483.1

EC 2.3.2.26

XP_024302824.1

EC 2.3.2.26

XP_047277238.1

EC 2.3.2.26

XP_047277239.1

EC 2.3.2.26

XP_047277240.1

EC 2.3.2.26

XP_047277241.1

EC 2.3.2.26

XP_054215606.1

EC 2.3.2.26

XP_054215607.1

EC 2.3.2.26

XP_054215608.1

EC 2.3.2.26

XP_054215609.1

EC 2.3.2.26

XP_054215610.1

EC 2.3.2.26

XP_054215611.1

EC 2.3.2.26

XP_054215612.1

EC 2.3.2.26

XP_054215613.1

EC 2.3.2.26

XP_054215614.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007013.4 → NP_008944.1 NEDD4-like E3 ubiquitin-protein ligase WWP1

See identical proteins and their annotated locations for NP_008944.1

Status: VALIDATED

Source sequence(s)

AC103760, AC103817, AW137654, AY043361, BC036065, BM664090

Consensus CDS

CCDS6242.1

UniProtKB/Swiss-Prot

O00307, Q5YLC1, Q96BP4, Q9H0M0

UniProtKB/TrEMBL

A8K9T5

Related

ENSP00000427793.1, ENST00000517970.6

Conserved Domains (2) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

COG5021
Location:307 → 922

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

86342547..86468503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024447056.2 → XP_024302824.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

UniProtKB/TrEMBL

A8K9T5

Conserved Domains (4) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:559 → 896

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:499 → 528

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:351 → 380

WW; WW domain
XM_005250761.5 → XP_005250818.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

UniProtKB/TrEMBL

A8K9T5

Conserved Domains (6) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00119
Location:590 → 918

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:567 → 919

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:498 → 527

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:350 → 379

WW; WW domain

pfam07010
Location:201 → 326

Endomucin; Endomucin
XM_047421282.1 → XP_047277238.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4
XM_005250760.5 → XP_005250817.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

See identical proteins and their annotated locations for XP_005250817.1

UniProtKB/Swiss-Prot

O00307, Q5YLC1, Q96BP4, Q9H0M0

UniProtKB/TrEMBL

A8K9T5

Related

ENSP00000265428.4, ENST00000265428.4

Conserved Domains (2) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

COG5021
Location:307 → 922

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
XM_017012994.3 → XP_016868483.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3

UniProtKB/TrEMBL

A8K9T5

Conserved Domains (4) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

cd00078
Location:559 → 896

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:499 → 528

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:351 → 380

WW; WW domain
XM_017012993.2 → XP_016868482.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2

UniProtKB/TrEMBL

A8K9T5

Conserved Domains (6) summary

cd04021
Location:17 → 140

C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase

smart00119
Location:590 → 918

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:567 → 919

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:498 → 527

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:350 → 379

WW; WW domain

pfam07010
Location:201 → 326

Endomucin; Endomucin
XM_047421283.1 → XP_047277239.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4
XM_047421285.1 → XP_047277241.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6
XM_047421284.1 → XP_047277240.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

87462833..87588744

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359634.1 → XP_054215609.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3
XM_054359632.1 → XP_054215607.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2
XM_054359636.1 → XP_054215611.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4
XM_054359631.1 → XP_054215606.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1

UniProtKB/Swiss-Prot

O00307, Q5YLC1, Q96BP4, Q9H0M0
XM_054359635.1 → XP_054215610.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X3
XM_054359633.1 → XP_054215608.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X2
XM_054359637.1 → XP_054215612.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X4
XM_054359639.1 → XP_054215614.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X6
XM_054359638.1 → XP_054215613.1 NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X5