U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lambdaTry [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36214, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    lambdaTryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043470
    Locus tag
    Dmel_CG12350
    See related
    AllianceGenome:FB:FBgn0043470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12350; Dmel\CG12350; LambdaTry; SP76
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in adult midgut enterocyte; embryonic midgut chamber; and embryonic/larval midgut. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See lambdaTry in Genome Data Viewer
    Location:
    47F3-47F3; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11336840..11337791)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7224345..7225296)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 47b Neighboring gene shavenoid Neighboring gene kappaTry Neighboring gene zetaTrypsin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Wittkopp PJ, et al. Genetics, 2006 Jul. PMID 16702434, Free PMC Article
    2. GATAe-dependent and -independent expressions of genes in the differentiated endodermal midgut of Drosophila. Okumura T, et al. Gene Expr Patterns, 2007 Jan. PMID 16914392
    3. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967
    4. A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Lipinszki Z, et al. Biochem J, 2013 Sep 15. PMID 23805892
    5. The digestive tract of Drosophila melanogaster. Lemaitre B, et al. Annu Rev Genet, 2013. PMID 24016187

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    lambdaTry
    Names
    CG12350-PA
    lambda-Trypsin
    lambdaTry-PA
    lambdaTrypsin
    NP_610673.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11336840..11337791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136829.4 → NP_610673.1  lambdaTry [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JPN9
      Related
      FBpp0087222
      Conserved Domains (2) summary
      smart00020
      Location:35 → 255
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:36 → 259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JPN9 Q7JPN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools