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    betaTry betaTrypsin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47901, updated on 10-May-2024

    Summary

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    Official Symbol
    betaTryprovided by FlyBase
    Official Full Name
    betaTrypsinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010357
    Locus tag
    Dmel_CG18211
    See related
    AllianceGenome:FB:FBgn0010357
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta; BetaTry; CG18211; DmBetaTry; Dmel\CG18211; SP119; Try
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. Is expressed in adult head; adult midgut enterocyte; and embryonic/larval digestive system. Orthologous to several human genes including PRSS22 (serine protease 22); PRSS27 (serine protease 27); and PRSS33 (serine protease 33). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

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    See betaTry in Genome Data Viewer
    Location:
    47F4-47F4; 2-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11346325..11347395)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7233830..7234900)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene alphaTrypsin Neighboring gene epsilonTrypsin Neighboring gene gammaTrypsin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gene family in Drosophila melanogaster coding for trypsin-like enzymes. Davis CA, et al. Nucleic Acids Res, 1985 Sep 25. PMID 2414727, Free PMC Article
    2. I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells. Buddika K, et al. Development, 2021 Jan 7. PMID 33246929, Free PMC Article
    3. Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model. Gilbert R, et al. NPJ Microgravity, 2020. PMID 32047838, Free PMC Article
    4. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article
    5. Concerted evolution within a trypsin gene cluster in Drosophila. Wang S, et al. Mol Biol Evol, 1999 Sep. PMID 10486967

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    betaTrypsin
    Names
    CG18211-PA
    CG18211-PB
    betaTry-PA
    betaTry-PB
    NP_001286314.1
    NP_524904.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11346325..11347395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299385.1 → NP_001286314.1  betaTrypsin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35004, Q9V5Y3
      UniProtKB/TrEMBL
      A0A0B4LF52
      Conserved Domains (2) summary
      smart00020
      Location:30 → 249
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:31 → 252
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_080165.3 → NP_524904.1  betaTrypsin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35004, Q9V5Y3
      UniProtKB/TrEMBL
      A0A0B4LF52
      Related
      FBpp0087223
      Conserved Domains (2) summary
      smart00020
      Location:30 → 249
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:31 → 252
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF52 A0A0B4LF52
    P35004.2 P35004

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