Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ugt2b1provided by MGI
Official Full Name: UDP glucuronosyltransferase 2 family, polypeptide B1provided by MGI
Primary source: MGI:MGI:1919023
See related: Ensembl:ENSMUSG00000035836 AllianceGenome:MGI:1919023
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300012D20Rik
Summary: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in biphenyl catabolic process; cellular glucuronidation; and estrogen metabolic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to several human genes including UGT2B4 (UDP glucuronosyltransferase family 2 member B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 36.8) See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (87064498..87074362, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86916639..86926503, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Title: Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
The metabolism of bisphenols by UGT2B1 in fetal, newborn, and maternal mice is reported.
Title: Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biphenyl catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular glucuronidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular glucuronidation	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic glucuronidation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP-glucuronosyltransferase 2B4

NP_690024.1

EC 2.4.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152811.1 → NP_690024.1 UDP-glucuronosyltransferase 2B4 precursor

See identical proteins and their annotated locations for NP_690024.1

Status: PROVISIONAL

Source sequence(s)

BC027200

Consensus CDS

CCDS19382.1

UniProtKB/TrEMBL

Q8R084

Related

ENSMUSP00000031183.3, ENSMUST00000031183.3

Conserved Domains (2) summary

PHA03392
Location:8 → 508

egt; ecdysteroid UDP-glucosyltransferase; Provisional

pfam00201
Location:24 → 527

UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase