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    ZNF337 zinc finger protein 337 [ Homo sapiens (human) ]

    Gene ID: 26152, updated on 11-Apr-2024

    Summary

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    Official Symbol
    ZNF337provided by HGNC
    Official Full Name
    zinc finger protein 337provided by HGNC
    Primary source
    HGNC:HGNC:15809
    See related
    Ensembl:ENSG00000130684 AllianceGenome:HGNC:15809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 5.9), endometrium (RPKM 5.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    20p11.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (25673195..25696853, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (25738693..25762362, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25653831..25677489, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ZNF337 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 594, pseudogene Neighboring gene mediator complex subunit 28 pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17674 Neighboring gene uncharacterized LOC107985400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25699573-25700088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:25700089-25700604 Neighboring gene vomeronasal 1 receptor 108 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17675 Neighboring gene uncharacterized LOC105372582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. Mao CG, et al. Thorac Cancer, 2020 Nov. PMID 33001583, Free PMC Article
    2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
    3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    5. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 337

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034058.1 RefSeqGene

      Range
      5052..28710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290261.2 → NP_001277190.1  zinc finger protein 337

      See identical proteins and their annotated locations for NP_001277190.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK125455, AL031673, BC021298, BX113975
      Consensus CDS
      CCDS13174.1
      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5
      Related
      ENSP00000365619.1, ENST00000376436.5
      Conserved Domains (7) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:234 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348 → 370
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:530 → 554
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:600 → 633
      DUF4193; Domain of unknown function (DUF4193)

    2. NM_015655.4 → NP_056470.1  zinc finger protein 337

      See identical proteins and their annotated locations for NP_056470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK291235, AL031673, BC021298, BP201424, BX113975
      Consensus CDS
      CCDS13174.1
      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5
      Related
      ENSP00000252979.5, ENST00000252979.6
      Conserved Domains (7) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:234 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348 → 370
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:530 → 554
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:600 → 633
      DUF4193; Domain of unknown function (DUF4193)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      25673195..25696853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260702.4 → XP_005260759.1  zinc finger protein 337 isoform X2

      See identical proteins and their annotated locations for XP_005260759.1

      UniProtKB/Swiss-Prot
      Q9Y3M9
      Conserved Domains (7) summary
      smart00349
      Location:12 → 52
      KRAB; krueppel associated box
      COG5048
      Location:202 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:316 → 338
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:358 → 383
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:568 → 601
      DUF4193; Domain of unknown function (DUF4193)

    2. XM_011529219.3 → XP_011527521.1  zinc finger protein 337 isoform X1

      See identical proteins and their annotated locations for XP_011527521.1

      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5
      Conserved Domains (7) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:234 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348 → 370
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:530 → 554
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:600 → 633
      DUF4193; Domain of unknown function (DUF4193)

    3. XM_006723558.5 → XP_006723621.1  zinc finger protein 337 isoform X1

      See identical proteins and their annotated locations for XP_006723621.1

      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5
      Conserved Domains (7) summary
      smart00349
      Location:12 → 71
      KRAB; krueppel associated box
      COG5048
      Location:234 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:350 → 370
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:348 → 370
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:530 → 554
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:600 → 633
      DUF4193; Domain of unknown function (DUF4193)

    4. XM_017027803.3 → XP_016883292.1  zinc finger protein 337 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y3M9
      Conserved Domains (7) summary
      smart00349
      Location:12 → 52
      KRAB; krueppel associated box
      COG5048
      Location:202 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:316 → 338
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:12 → 51
      KRAB; KRAB box
      pfam13465
      Location:358 → 383
      zf-H2C2_2; Zinc-finger double domain
      pfam13834
      Location:568 → 601
      DUF4193; Domain of unknown function (DUF4193)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      25738693..25762362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323348.1 → XP_054179323.1  zinc finger protein 337 isoform X2

    2. XM_054323347.1 → XP_054179322.1  zinc finger protein 337 isoform X1

      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5

    3. XM_054323346.1 → XP_054179321.1  zinc finger protein 337 isoform X1

      UniProtKB/Swiss-Prot
      B4DSM2, Q9Y3M9, Q9Y3Y5

    4. XM_054323349.1 → XP_054179324.1  zinc finger protein 337 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y3M9.2 GenPept UniProtKB/Swiss-Prot:Q9Y3M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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