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    Zfp995 zinc finger protein 995 [ Mus musculus (house mouse) ]

    Gene ID: 70081, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp995provided by MGI
    Official Full Name
    zinc finger protein 995provided by MGI
    Primary source
    MGI:MGI:1917331
    See related
    Ensembl:ENSMUSG00000078546 AllianceGenome:MGI:1917331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210404O09Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 1.4), bladder adult (RPKM 1.3) and 19 other tissues See more
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    Genomic context

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    Location:
    17 A3.3; 17 11.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (22097888..22129060, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21878907..21910085, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42017 Neighboring gene zinc finger protein 760 pseudogene Neighboring gene zinc finger protein 820 Neighboring gene predicted gene, 31758 Neighboring gene STARR-seq mESC enhancer starr_42018 Neighboring gene STARR-seq mESC enhancer starr_42019 Neighboring gene STARR-seq mESC enhancer starr_42020 Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene zinc finger protein 942 Neighboring gene STARR-positive B cell enhancer ABC_E11628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC70081

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256493.1 → NP_001243422.1  uncharacterized protein LOC70081

      See identical proteins and their annotated locations for NP_001243422.1

      Status: VALIDATED

      Source sequence(s)
      AI180682, BY741152, CT009755
      Consensus CDS
      CCDS57051.1
      UniProtKB/TrEMBL
      E9Q6M3
      Related
      ENSMUSP00000139581.2, ENSMUST00000190066.7
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      22097888..22129060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160782.1 → XP_036016675.1  uncharacterized protein LOC70081 isoform X1

      UniProtKB/TrEMBL
      E9Q6M3
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    2. XM_036160780.1 → XP_036016673.1  uncharacterized protein LOC70081 isoform X1

      UniProtKB/TrEMBL
      E9Q6M3
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    3. XM_036160781.1 → XP_036016674.1  uncharacterized protein LOC70081 isoform X1

      UniProtKB/TrEMBL
      E9Q6M3
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    4. XM_030250038.2 → XP_030105898.1  uncharacterized protein LOC70081 isoform X1

      UniProtKB/TrEMBL
      E9Q6M3
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    5. XM_036160779.1 → XP_036016672.1  uncharacterized protein LOC70081 isoform X1

      UniProtKB/TrEMBL
      E9Q6M3
      Conserved Domains (4) summary
      COG5048
      Location:201 → 436
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:13 → 52
      KRAB; KRAB box

    6. XM_030250042.2 → XP_030105902.1  uncharacterized protein LOC70081 isoform X2

      Conserved Domains (5) summary
      COG5048
      Location:237 → 380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:269 → 289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:162 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:198 → 222
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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